Sleep Disturbance as a Nontraditional Risk Factor in CKD
睡眠障碍是 CKD 的非传统危险因素
基本信息
- 批准号:7987601
- 负责人:
- 金额:$ 10.46万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-11-25 至 2011-08-31
- 项目状态:已结题
- 来源:
- 关键词:AdultAdverse effectsAgeAncillary StudyAnkleBlood PressureBody FluidsC-reactive proteinCardiovascular DiseasesCardiovascular PhysiologyCardiovascular systemCessation of lifeCharacteristicsChicagoChronicChronic DiseaseChronic Kidney FailureChronic Kidney InsufficiencyClinical ResearchCohort StudiesDeteriorationDevelopmentDiabetes MellitusEnd stage renal failureEnrollmentEpidemicEpidemiologyEquilibriumEthnic OriginEventExcessive Daytime SleepinessFluid BalanceFunctional disorderGenderGeneral PopulationGlomerular Filtration RateHeart RateHome environmentHormonalHormonesHyperactive behaviorHypertensionIllinoisInflammatoryInsulin ResistanceKidneyLaboratoriesLaboratory StudyLeft Ventricular MassLegLinkMeasuresMonitorMovementMovement DisordersNational Institute of Diabetes and Digestive and Kidney DiseasesObesityOverweightPathologyPatientsPatternPlasmaPolysomnographyPrevalencePublic HealthQuestionnairesRecruitment ActivityRenal functionRenin-Angiotensin-Aldosterone SystemResearch PersonnelRestless Legs SyndromeRiskRisk FactorsRoleSample SizeSeveritiesSleepSleep Apnea SyndromesSleep disturbancesSleeplessnessSocietiesStudy SubjectTestingUniversitiesWakefulnessWristcardiovascular risk factorcohortcytokinediabetic patientglucose tolerancehigh riskimprovedindexingmortalitynon-diabeticprograms
项目摘要
There is increasing evidence from both epidemiologic and laboratory studies for an association between
sleep duration and/or quality and the prevalence and/or severity of major chronic diseases, including
diabetes and cardiovascular disease. Sleep disturbances, particularly sleep disordered breathing (SDB)
and periodic leg movements (PLM), are more prevalent in patients with chronic kidney disease (CKD) than
in the general population. Because the hormones involved in the control of kidney function are markedly
modulated by sleep, it is possible that sleep disturbances have an adverse effect on kidney function. The
present proposal therefore seeks to explore the role of decreased sleep duration and/or quality as a risk
factor for the progression of chronic renal insufficiency and the development of cardiovascular disease in
CKD. This study has two over-arching hypotheses: 1. Sleep quality will be a predictor of the progression
of CKD, and 2. Sleep quality will be a predictor of cardiovascular disease in CKD. This project will be an
ancillary study to an ongoing longitudinal cohort study, the Chronic Renal Insufficiency Study (CRIC).
Specific Aim 1 will involve assessment of habitual at-home sleep duration and quality (by wrist and leg
activity monitoring, logs and questionnaires) to predict changes in renal and cardiovascular measures over
study period in CRIC subjects. Specific Aim 2 will examine changes in polysomnographic variables,
including measures of SDB and PLM, to predict changes in renal and cardiovascular measures over study
period in CRIC subjects. Specific Aim 3 will delineate the relationship between hormones controlling body
fluid balance, cardiovascular function and sleep in mild to moderate CKD patients as compared to normal
controls to identify possible pathophysiological mechanisms. Overall, the proposed studies will determine if
poor sleep quality accelerates the development or increases the severity of CKD and of cardiovascular
disease in CKD and if strategies to improve sleep quality may have beneficial effects on CKD.
流行病学和实验室研究越来越多的证据表明,
睡眠持续时间和/或质量以及主要慢性疾病的患病率和/或严重程度,包括
糖尿病和心血管疾病。睡眠障碍,特别是睡眠呼吸障碍 (SDB)
和周期性腿部运动 (PLM) 在慢性肾脏病 (CKD) 患者中比
在一般人群中。因为参与控制肾功能的激素明显
睡眠受到睡眠调节,睡眠障碍可能会对肾功能产生不利影响。这
因此,本提案旨在探讨睡眠持续时间和/或质量减少作为风险的作用
慢性肾功能不全进展和心血管疾病发展的因素
慢性肾病。这项研究有两个总体假设: 1. 睡眠质量将是进展的预测因素
2. 睡眠质量将是 CKD 心血管疾病的预测因子。该项目将是一个
正在进行的纵向队列研究慢性肾功能不全研究(CRIC)的辅助研究。
具体目标 1 将涉及评估习惯性在家睡眠持续时间和质量(通过手腕和腿部
活动监测、日志和问卷)来预测肾脏和心血管指标的变化
CRIC科目的学习期。具体目标 2 将检查多导睡眠图变量的变化,
包括 SDB 和 PLM 的测量,以预测研究期间肾脏和心血管测量的变化
CRIC 主题期间。具体目标3将描述控制身体的激素之间的关系
与正常人相比,轻至中度 CKD 患者的液体平衡、心血管功能和睡眠
控制以确定可能的病理生理机制。总体而言,拟议的研究将确定是否
睡眠质量差会加速 CKD 和心血管疾病的发展或加重其严重程度
慢性肾病 (CKD) 疾病以及改善睡眠质量的策略是否可能对慢性肾病 (CKD) 产生有益影响。
项目成果
期刊论文数量(0)
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会议论文数量(0)
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Eve Van Cauter其他文献
Eve Van Cauter的其他文献
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{{ truncateString('Eve Van Cauter', 18)}}的其他基金
Cardiometabolic Risk of Shift Work: Sleep Loss vs. Circadian Disruption
轮班工作的心脏代谢风险:睡眠不足与昼夜节律紊乱
- 批准号:
8105047 - 财政年份:2009
- 资助金额:
$ 10.46万 - 项目类别:
Cardiometabolic Risk of Shift Work: Sleep Loss vs. Circadian Disruption
轮班工作的心脏代谢风险:睡眠不足与昼夜节律紊乱
- 批准号:
7730682 - 财政年份:2009
- 资助金额:
$ 10.46万 - 项目类别:
Cardiometabolic Risk of Shift Work: Sleep Loss vs. Circadian Disruption
轮班工作的心脏代谢风险:睡眠不足与昼夜节律紊乱
- 批准号:
8294372 - 财政年份:2009
- 资助金额:
$ 10.46万 - 项目类别:
EXTENDED WORK SCHEDULES AND HEALTH: ROLE OF SLEEP LOSS
延长工作时间与健康:睡眠不足的影响
- 批准号:
7604747 - 财政年份:2007
- 资助金额:
$ 10.46万 - 项目类别:
ENDOCRINE, METABOLIC, COGNITIVE FUNCTIONS IN SHORT & LONG SLEEPERS
内分泌、代谢、认知功能简述
- 批准号:
7378658 - 财政年份:2006
- 资助金额:
$ 10.46万 - 项目类别:
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