Sleep Disturbance as a Nontraditional Risk Factor in CKD
睡眠障碍是 CKD 的非传统危险因素
基本信息
- 批准号:7987601
- 负责人:
- 金额:$ 10.46万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-11-25 至 2011-08-31
- 项目状态:已结题
- 来源:
- 关键词:AdultAdverse effectsAgeAncillary StudyAnkleBlood PressureBody FluidsC-reactive proteinCardiovascular DiseasesCardiovascular PhysiologyCardiovascular systemCessation of lifeCharacteristicsChicagoChronicChronic DiseaseChronic Kidney FailureChronic Kidney InsufficiencyClinical ResearchCohort StudiesDeteriorationDevelopmentDiabetes MellitusEnd stage renal failureEnrollmentEpidemicEpidemiologyEquilibriumEthnic OriginEventExcessive Daytime SleepinessFluid BalanceFunctional disorderGenderGeneral PopulationGlomerular Filtration RateHeart RateHome environmentHormonalHormonesHyperactive behaviorHypertensionIllinoisInflammatoryInsulin ResistanceKidneyLaboratoriesLaboratory StudyLeft Ventricular MassLegLinkMeasuresMonitorMovementMovement DisordersNational Institute of Diabetes and Digestive and Kidney DiseasesObesityOverweightPathologyPatientsPatternPlasmaPolysomnographyPrevalencePublic HealthQuestionnairesRecruitment ActivityRenal functionRenin-Angiotensin-Aldosterone SystemResearch PersonnelRestless Legs SyndromeRiskRisk FactorsRoleSample SizeSeveritiesSleepSleep Apnea SyndromesSleep disturbancesSleeplessnessSocietiesStudy SubjectTestingUniversitiesWakefulnessWristcardiovascular risk factorcohortcytokinediabetic patientglucose tolerancehigh riskimprovedindexingmortalitynon-diabeticprograms
项目摘要
There is increasing evidence from both epidemiologic and laboratory studies for an association between
sleep duration and/or quality and the prevalence and/or severity of major chronic diseases, including
diabetes and cardiovascular disease. Sleep disturbances, particularly sleep disordered breathing (SDB)
and periodic leg movements (PLM), are more prevalent in patients with chronic kidney disease (CKD) than
in the general population. Because the hormones involved in the control of kidney function are markedly
modulated by sleep, it is possible that sleep disturbances have an adverse effect on kidney function. The
present proposal therefore seeks to explore the role of decreased sleep duration and/or quality as a risk
factor for the progression of chronic renal insufficiency and the development of cardiovascular disease in
CKD. This study has two over-arching hypotheses: 1. Sleep quality will be a predictor of the progression
of CKD, and 2. Sleep quality will be a predictor of cardiovascular disease in CKD. This project will be an
ancillary study to an ongoing longitudinal cohort study, the Chronic Renal Insufficiency Study (CRIC).
Specific Aim 1 will involve assessment of habitual at-home sleep duration and quality (by wrist and leg
activity monitoring, logs and questionnaires) to predict changes in renal and cardiovascular measures over
study period in CRIC subjects. Specific Aim 2 will examine changes in polysomnographic variables,
including measures of SDB and PLM, to predict changes in renal and cardiovascular measures over study
period in CRIC subjects. Specific Aim 3 will delineate the relationship between hormones controlling body
fluid balance, cardiovascular function and sleep in mild to moderate CKD patients as compared to normal
controls to identify possible pathophysiological mechanisms. Overall, the proposed studies will determine if
poor sleep quality accelerates the development or increases the severity of CKD and of cardiovascular
disease in CKD and if strategies to improve sleep quality may have beneficial effects on CKD.
流行病学和实验室研究都有越来越多的证据表明,
睡眠持续时间和/或质量以及主要慢性疾病的患病率和/或严重程度,包括
糖尿病和心血管疾病。睡眠障碍,特别是睡眠呼吸障碍(SDB)
和周期性腿部运动(PLM),在慢性肾脏病(CKD)患者中比
在普通人群中的比例。因为参与控制肾功能的激素明显
由于睡眠受到调节,睡眠障碍可能对肾功能有不利影响。的
因此,本提案寻求探索睡眠持续时间和/或质量降低作为风险的作用
慢性肾功能不全和心血管疾病进展的因素
CKD。本研究有两个过度假设:1。睡眠质量将是疾病进展的预测指标
慢性肾脏病,以及2.睡眠质量将是CKD患者心血管疾病的预测因子。该项目将是一个
慢性肾功能不全研究(CRIC)是一项正在进行的纵向队列研究的辅助研究。
具体目标1将涉及评估习惯性在家睡眠持续时间和质量(通过手腕和腿
活动监测、日志和问卷),以预测肾脏和心血管指标的变化,
在审评委专题研究期间。具体目标2将检查多导睡眠图变量的变化,
包括SDB和PLM指标,以预测研究期间肾脏和心血管指标的变化
在审评委的议题中。具体目标3将阐明控制身体的激素之间的关系
轻度至中度CKD患者与正常人相比的液体平衡、心血管功能和睡眠
控制,以确定可能的病理生理机制。总体而言,拟议的研究将确定,
睡眠质量差会加速CKD和心血管疾病的发展或增加其严重程度。
CKD中的疾病和改善睡眠质量的策略可能对CKD有有益的影响。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Eve Van Cauter其他文献
Eve Van Cauter的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Eve Van Cauter', 18)}}的其他基金
Cardiometabolic Risk of Shift Work: Sleep Loss vs. Circadian Disruption
轮班工作的心脏代谢风险:睡眠不足与昼夜节律紊乱
- 批准号:
8105047 - 财政年份:2009
- 资助金额:
$ 10.46万 - 项目类别:
Cardiometabolic Risk of Shift Work: Sleep Loss vs. Circadian Disruption
轮班工作的心脏代谢风险:睡眠不足与昼夜节律紊乱
- 批准号:
7730682 - 财政年份:2009
- 资助金额:
$ 10.46万 - 项目类别:
Cardiometabolic Risk of Shift Work: Sleep Loss vs. Circadian Disruption
轮班工作的心脏代谢风险:睡眠不足与昼夜节律紊乱
- 批准号:
8294372 - 财政年份:2009
- 资助金额:
$ 10.46万 - 项目类别:
EXTENDED WORK SCHEDULES AND HEALTH: ROLE OF SLEEP LOSS
延长工作时间与健康:睡眠不足的影响
- 批准号:
7604747 - 财政年份:2007
- 资助金额:
$ 10.46万 - 项目类别:
ENDOCRINE, METABOLIC, COGNITIVE FUNCTIONS IN SHORT & LONG SLEEPERS
内分泌、代谢、认知功能简述
- 批准号:
7378658 - 财政年份:2006
- 资助金额:
$ 10.46万 - 项目类别:
相似海外基金
Unraveling Adverse Effects of Checkpoint Inhibitors Using iPSC-derived Cardiac Organoids
使用 iPSC 衍生的心脏类器官揭示检查点抑制剂的副作用
- 批准号:
10591918 - 财政年份:2023
- 资助金额:
$ 10.46万 - 项目类别:
Optimization of mRNA-LNP vaccine for attenuating adverse effects and analysis of mechanism behind adverse effects
mRNA-LNP疫苗减轻不良反应的优化及不良反应机制分析
- 批准号:
23K15383 - 财政年份:2023
- 资助金额:
$ 10.46万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Elucidation of adverse effects of combined exposure to low-dose chemicals in the living environment on allergic diseases and attempts to reduce allergy
阐明生活环境中低剂量化学品联合暴露对过敏性疾病的不良影响并尝试减少过敏
- 批准号:
23H03556 - 财政年份:2023
- 资助金额:
$ 10.46万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Green tea-based nano-enhancer as an adjuvant for amplified efficacy and reduced adverse effects in anti-angiogenic drug treatments
基于绿茶的纳米增强剂作为抗血管生成药物治疗中增强疗效并减少不良反应的佐剂
- 批准号:
23K17212 - 财政年份:2023
- 资助金额:
$ 10.46万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Effects of Tobacco Heating System on the male reproductive function and towards to the reduce of the adverse effects.
烟草加热系统对男性生殖功能的影响以及减少不利影响。
- 批准号:
22H03519 - 财政年份:2022
- 资助金额:
$ 10.46万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Mitigating the Adverse Effects of Ultrafines in Pressure Filtration of Oil Sands Tailings
减轻油砂尾矿压力过滤中超细粉的不利影响
- 批准号:
563657-2021 - 财政年份:2022
- 资助金额:
$ 10.46万 - 项目类别:
Alliance Grants
1/4-Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)
1/4-破译ECT结果和不良反应的机制(DECODE)
- 批准号:
10521849 - 财政年份:2022
- 资助金额:
$ 10.46万 - 项目类别:
4/4-Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)
4/4-破译ECT结果和不良反应的机制(DECODE)
- 批准号:
10671022 - 财政年份:2022
- 资助金额:
$ 10.46万 - 项目类别:
2/4 Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)
2/4 ECT 结果和不良反应的破译机制(DECODE)
- 批准号:
10670918 - 财政年份:2022
- 资助金额:
$ 10.46万 - 项目类别:
Downsides of downhill: The adverse effects of head vibration associated with downhill mountain biking on visuomotor and cognitive function
速降的缺点:与速降山地自行车相关的头部振动对视觉运动和认知功能的不利影响
- 批准号:
2706416 - 财政年份:2022
- 资助金额:
$ 10.46万 - 项目类别:
Studentship