Modulation of Vegfc/Vegfr3 signaling at the extracellular matrix during embryonic lymphangiogenesis

胚胎淋巴管生成过程中细胞外基质 Vegfc/Vegfr3 信号传导的调节

• 批准号: nhmrc : 1050138
• 负责人: A/Pr Benjamin Hogan
• 金额: $ 38.07万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/modulation-vegfcvegfr3-signaling-embryonic-lymphangiogenesis/112138
• 关键词: Modulation; Vegfc; Vegfr3; signaling; extracellular

Lymphatic vessels play important roles in vascular diseases and cancer. However, we are yet to understand how they form during development and disease. We recently identified the gene CCBE1, essential for the formation of lymphatic vessels and responsible for lymphatic dysplasia in humans. This study aims to understand the molecular pathway in which CCBE1 acts. This work aims to characterize new molecular pathways in lymphatic vessels in order to identify new therapeutic targets in lymphatic disease and cancer.

淋巴管在血管疾病和癌症中起着重要作用。然而，我们还不知道它们在发育和疾病过程中是如何形成的。我们最近发现了CCBE1基因，它对淋巴管的形成是必不可少的，并与人类的淋巴发育不良有关。本研究旨在了解CCBE1的分子作用途径。这项工作旨在表征淋巴管中的新分子通路，以确定淋巴疾病和癌症的新治疗靶点。