Characterisation of conserved Sox18-dependent genes in lymphatic vascular development
Characterisation of conserved Sox18-dependent genes in lymphatic vascular development
批准号:
nhmrc : 1008586
负责人:
A/Pr Benjamin Hogan
金额:
$26.76万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2011
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2011-01-01 至 2013-12-31
中文摘要
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英文摘要
Lymphatic vessels are important in a number of diseases including lymphoedema and cancer. There is a significant gap in our basic understanding of how lymphatic vessels form. We have identified a series of genes that are regulated downstream of the lymphatic master gene Sox18 in mouse lymphatic vessels. This study aims to characterise these genes using complementary model systems. The genes and pathways identified will represent potential therapeutic targets in a number of disease contexts.
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会议论文
Mechanisms of vascular development in health and disease
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批准号:nhmrc : GNT1155221
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Understanding the role of the atypical cadherin Fat4 in lymphatic vascular development
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Understanding the role of the atypical cadherin Fat4 in lymphatic vascular development
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财政年份:2018
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依托单位:
Coupling the mechanical, signalling and transcriptional mechanisms that initiate pathogenesis of Cerebral Cavernous Malformation
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批准号:nhmrc : 1124011
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资助金额:$83.93万
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财政年份:2017
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依托单位:
Coupling the mechanical, signalling and transcriptional mechanisms that initiate pathogenesis of Cerebral Cavernous Malformation
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批准号:nhmrc : GNT1124011
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资助金额:$122.84万
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财政年份:2017
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负责人:A/Pr Benjamin Hogan
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依托单位:
Characterisation of a newly identified, indispensible, transcriptional regulator of lymphangiogenesis
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批准号:nhmrc : GNT1107755
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资助金额:$53.52万
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财政年份:2016
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依托单位:
Characterisation of a newly identified, indispensible, transcriptional regulator of lymphangiogenesis
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批准号:nhmrc : 1107755
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资助金额:$36.68万
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财政年份:2016
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负责人:A/Pr Benjamin Hogan
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依托单位:
A critical new signaling axis in lymphatic vascular angiogenesis
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批准号:nhmrc : 1079158
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资助金额:$46.73万
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财政年份:2015
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负责人:A/Pr Benjamin Hogan
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依托单位:
Novel transcription factor regulation of lymphatic vascular angiogenesis in health and disease
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批准号:nhmrc : 1079670
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资助金额:$55.45万
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财政年份:2015
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负责人:A/Pr Benjamin Hogan
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依托单位:
The genetic and cellular control of lymphangiogenesis in health and disease
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批准号:nhmrc : 1083811
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资助金额:$31.71万
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财政年份:2015
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负责人:A/Pr Benjamin Hogan
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依托单位:
The genetic and cellular control of lymphangiogenesis in health and disease
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批准号:nhmrc : GNT1083811
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项目类别:Career Development Fellowships
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资助金额:$45.55万
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财政年份:2015
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负责人:A/Pr Benjamin Hogan
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依托单位:
Novel transcription factor regulation of lymphatic vascular angiogenesis in health and disease
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批准号:nhmrc : GNT1079670
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项目类别:Project Grants
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资助金额:$80.01万
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财政年份:2015
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负责人:A/Pr Benjamin Hogan
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依托单位:
Using high-throughput genomics to reveal the deleterious genetic changes that underlie paediatric leukoencephalopathies
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财政年份:2014
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依托单位:
Uncovering a novel genetic interaction that governs blood vessel development in health and disease
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资助金额:$41.78万
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财政年份:2013
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负责人:A/Pr Benjamin Hogan
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依托单位:
Modulation of Vegfc/Vegfr3 signaling at the extracellular matrix during embryonic lymphangiogenesis
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批准号:nhmrc : 1050138
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资助金额:$38.07万
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财政年份:2013
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负责人:A/Pr Benjamin Hogan
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依托单位:
Functional and molecular characterization of a novel regulator of angiogenesis
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批准号:nhmrc : 1046028
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项目类别:Project Grants
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资助金额:$31.67万
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财政年份:2013
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依托单位:
The mechanism of ccbe1 function during lymphangiogenesis
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批准号:nhmrc : 631657
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项目类别:NHMRC Project Grants
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资助金额:$33.5万
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财政年份:2010
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负责人:A/Pr Benjamin Hogan
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依托单位:
Genetic control of embryonic lymphangiogenesis
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批准号:nhmrc : 433628
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项目类别:Early Career Fellowships
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财政年份:2007
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依托单位:
海外基金