The mechanism of ccbe1 function during lymphangiogenesis
The mechanism of ccbe1 function during lymphangiogenesis
批准号:
nhmrc : 631657
负责人:
A/Pr Benjamin Hogan
金额:
$33.5万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2010
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2010-01-01 至 2012-12-31
中文摘要
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英文摘要
Tumours induce the regional growth of lymphatic vessels (in a process termed lymphangiogenesis) and then spread (a process termed metastasis) via lymphatic vessels and lymph nodes. Inhibiting lymphangiogenesis can inhibit metastasis. We have identified a gene called ccbe1 that is essential for lymphangiogenesis during development. We aim to understand how this potential therapeutic target functions at the molecular level during lymphangiogenesis.
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Understanding the role of the atypical cadherin Fat4 in lymphatic vascular development
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Coupling the mechanical, signalling and transcriptional mechanisms that initiate pathogenesis of Cerebral Cavernous Malformation
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Coupling the mechanical, signalling and transcriptional mechanisms that initiate pathogenesis of Cerebral Cavernous Malformation
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依托单位:
Characterisation of a newly identified, indispensible, transcriptional regulator of lymphangiogenesis
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批准号:nhmrc : GNT1107755
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依托单位:
Characterisation of a newly identified, indispensible, transcriptional regulator of lymphangiogenesis
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A critical new signaling axis in lymphatic vascular angiogenesis
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Novel transcription factor regulation of lymphatic vascular angiogenesis in health and disease
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The genetic and cellular control of lymphangiogenesis in health and disease
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财政年份:2015
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负责人:A/Pr Benjamin Hogan
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依托单位:
The genetic and cellular control of lymphangiogenesis in health and disease
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项目类别:Career Development Fellowships
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资助金额:$45.55万
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财政年份:2015
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负责人:A/Pr Benjamin Hogan
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依托单位:
Novel transcription factor regulation of lymphatic vascular angiogenesis in health and disease
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批准号:nhmrc : GNT1079670
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项目类别:Project Grants
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资助金额:$80.01万
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财政年份:2015
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Using high-throughput genomics to reveal the deleterious genetic changes that underlie paediatric leukoencephalopathies
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财政年份:2014
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负责人:A/Pr Benjamin Hogan
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依托单位:
Uncovering a novel genetic interaction that governs blood vessel development in health and disease
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批准号:nhmrc : 1048242
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项目类别:Project Grants
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资助金额:$41.78万
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财政年份:2013
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负责人:A/Pr Benjamin Hogan
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依托单位:
Modulation of Vegfc/Vegfr3 signaling at the extracellular matrix during embryonic lymphangiogenesis
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批准号:nhmrc : 1050138
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项目类别:Project Grants
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资助金额:$38.07万
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财政年份:2013
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负责人:A/Pr Benjamin Hogan
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依托单位:
Functional and molecular characterization of a novel regulator of angiogenesis
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批准号:nhmrc : 1046028
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项目类别:Project Grants
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资助金额:$31.67万
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财政年份:2013
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负责人:A/Pr Benjamin Hogan
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依托单位:
Characterisation of conserved Sox18-dependent genes in lymphatic vascular development
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批准号:nhmrc : 1008586
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项目类别:NHMRC Project Grants
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资助金额:$26.76万
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财政年份:2011
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负责人:A/Pr Benjamin Hogan
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依托单位:
Genetic control of embryonic lymphangiogenesis
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批准号:nhmrc : 433628
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项目类别:Early Career Fellowships
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资助金额:$26.02万
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财政年份:2007
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负责人:A/Pr Benjamin Hogan
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依托单位:
国内基金
海外基金
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