Coupling the mechanical, signalling and transcriptional mechanisms that initiate pathogenesis of Cerebral Cavernous Malformation
Coupling the mechanical, signalling and transcriptional mechanisms that initiate pathogenesis of Cerebral Cavernous Malformation
批准号:
nhmrc : GNT1124011
负责人:
A/Pr Benjamin Hogan
金额:
$122.84万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2017
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2017-01-01 至 --
中文摘要
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英文摘要
Cerebral cavernous malformations (CCMs) are thin walled, vascular malformations in the brain found in 1/200-250 individuals. They can cause migraine, neurological deficits or stroke. This disease can be inherited due to damaging mutations in any of three CCM genes. The project will investigate the molecular control of CCM pathogenesis in animal models. We aim to uncover the molecular cause of these vascular malformations and in doing so identify new therapeutic strategies.
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会议论文
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Coupling the mechanical, signalling and transcriptional mechanisms that initiate pathogenesis of Cerebral Cavernous Malformation
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海外基金
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