Novel transcription factor regulation of lymphatic vascular angiogenesis in health and disease

健康和疾病中淋巴血管生成的新型转录因子调节

• 批准号: nhmrc : 1079670
• 负责人: A/Pr Benjamin Hogan
• 金额: $ 55.45万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-transcription-factor-health-disease/518686
• 关键词: Novel; transcription; factor; regulation; lymphatic

Lymphatic vessels control tissue fluid drainage, inflammatory processes and cancer progression. We have used genetic approaches to discover an unexpected role for a family of factors (transcription factors) that regulate new lymphatic vessel formation. This project will investigate this biological function of these genes in detail in vascular formation. The project aims to generate important knowledge for vascular biology, vascular pathologies, cancer spread and future therapeutics.

淋巴管控制组织液引流、炎症过程和癌症进展。我们已经使用遗传学方法发现了一个意想不到的作用，一个家庭的因素（转录因子），调节新的淋巴管形成。本项目将详细研究这些基因在血管形成中的生物学功能。该项目旨在为血管生物学、血管病理学、癌症扩散和未来治疗学提供重要知识。