NEUROENDOCRINE MEDIATION OF SOCIALLY INDUCED ANOVULATION

社会诱发的无排卵的神经内分泌调节

• 批准号: 7715755
• 负责人: Mark E Wilson
• 金额: $ 2.85万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715755
• 关键词: Adult; Alleles; Allopregnanolone; Anovulation; Anti-Anxiety Agents; Behavioral; Computer Retrieval of Information on Scientific Projects Database; Corticotropin-Releasing Hormone; Data Analyses; Depressed mood; End Point; Female; Funding; Genes; Genetic Polymorphism; Grant; Hormone Antagonists; Individual; Infertility; Institution; Length; Leptin; Macaca mulatta; Mediation; Metabolic; Neurosecretory Systems; Numbers; Outcome; Progesterone; Psychosocial Stress; Research; Research Personnel; Resources; Serotonin; Source; Stress; Supplementation; Testing; Thyroid Hormones; Transcriptional Activation; United States National Institutes of Health; Up-Regulation; Variant; Woman; hypothalamic-pituitary-adrenal axis; insight; novel; promoter; psychosocial; reproductive; research study; response; reuptake; social; stressor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Studies have continued this year assessing the consequences of psychosocial stress, resulting from social subordination, on metabolic, reproductive, and behavioral outcomes I adult female rhesus monkeys. In addition, the contribution of polymorphisms in the gene that encodes the serotonin reuptake transporter (5HTTLPR) was evaluated as other studies show individuals carrying one or both alleles of the short promoter length variant (s-variant) are more vulnerable to the adverse consequences of psychosocial stress than females homozygous for the long promoter length (l/l). Two experiments were conducted in the current year. The initial study assessed the effects of supplementation of leptin to test the hypothesis that leptin acts centrally to minimize the response to psychosocial stressors and to determine whether leptin normalizes thyroid hormone levels known to be depressed by social subordination. The second experiment tested the hypothesis that allopregnanolone, a neuroactive metabolite of progesterone, would be anxiolytic and reduce activation of the hypothalamic pituitary adrenal axis to novel situations. The analyses of the data from both of these experiments are still under way. In the coming year, we will assess the effects of a corticotropin releasing hormone (CRH) antagonist on a number of metabolic and reproductive endpoints to test the hypothesis that the reproductive deficits observed in subordinate females are the result of an up-regulation of CRH, and will provide insights into possible treatment strategies for women suffering from stress-induced infertility.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 今年继续进行的研究评估了社会从属关系导致的心理社会压力对成年雌性恒河猴代谢、生殖和行为结果的影响。 此外，对编码5-羟色胺再摄取转运蛋白（5 HTTLPR）的基因多态性的贡献进行了评估，因为其他研究表明，携带短启动子长度变体（s-变体）的一个或两个等位基因的个体比长启动子长度（l/l）纯合子的女性更容易受到心理社会压力的不良后果的影响。 本年度进行了两项实验。 最初的研究评估了补充瘦素的效果，以检验瘦素起着中枢作用以最大限度地减少对心理社会压力的反应的假设，并确定瘦素是否使已知因社会从属关系而抑郁的甲状腺激素水平正常化。 第二个实验测试的假设，别孕烯醇酮，孕酮的神经活性代谢物，将抗焦虑和减少激活下丘脑垂体肾上腺轴的新情况。 对这两项实验数据的分析仍在进行之中。 在未来的一年中，我们将评估促肾上腺皮质激素释放激素（CRH）拮抗剂对一些代谢和生殖终点的影响，以检验以下假设，即在下属女性中观察到的生殖缺陷是CRH上调的结果，并将为患有压力诱导的不孕症的妇女提供可能的治疗策略的见解。