CSHL Neurobiology of Drosophila Course

描述（由申请人提供）：拟议的2.5周课程的主要目标是提供现代和新兴实验方法的最先进的培训，以研究主要的无脊椎动物模型系统，果蝇的神经系统。果蝇神经生物学课程：基因，电路和行为旨在向学生介绍各种主题和技术，包括研究果蝇神经系统发育，连接和行为的最新方法。每日的研究研讨会提供神经系统功能和行为的特定子领域的全面概述，或专注于特定的技术和方法来研究苍蝇神经生物学的各个方面。该课程充分利用果蝇的遗传学作为分析神经发育，神经元生理学和行为的实验系统。该课程强调了这个强大的模型系统的相关性，以促进我们对人类大脑功能和功能障碍的理解。教师的选择是基于他们对该领域的贡献和知识，每个教师都在一个特定领域提供深入的专业知识，以补充其他领域。 反过来，导师们邀请在各自领域做出重大贡献的讲师们提供关于当前研究的最新报告。受训人员由课程教师从更大的申请者中选择，范围从高级研究生到主要研究员。由于课程时间短，无论是高年级还是低年级的人都可以参加，并在一个远离其他需要他们时间和注意力的环境中接受短期的密集培训。这个神经生物学实验室课程也为科学家提供了一个不寻常的机会，使他们能够在神经科学中快速了解先进的无脊椎动物模型，并将他们学到的概念和技术应用于自己的研究兴趣。该课程特别努力包括不同的参与者群体，特别注意包括妇女，美国少数民族和国家和国际科学家的良好平衡。 公共卫生相关性：一百多年来，果蝇（Drosophila melanogaster）被证明是帮助科学家了解动物遗传学原理的有力工具。在过去的几十年里，快速繁殖和突变这些小苍蝇的能力已经被用来阐明苍蝇大脑的结构和功能。复杂的基因实验提供了大量关于基因和分子的信息，这些基因和分子对帮助构建大脑很重要，关于形成大脑解剖结构的神经元回路和连接，以及关于在解剖结构中编码的复杂行为。此外，模型系统可以帮助我们了解这些分子，电路和行为是如何改变或影响的动物适应和学习新的环境，神经元损伤和/或损失如何导致疾病，以及如何在暴露于环境干扰或成瘾的化学物质时改变大脑功能。了解这些系统如何在果蝇中工作，对于我们阐明这些东西如何在高等动物中发挥作用的努力具有巨大的相关性，其后果包括我们如何看待神经系统疾病，大脑进化以及人类研究的其他主要主题，包括酒精和药物滥用。拟议的短期课程旨在向高级学生和资深调查员提供关于这一重要示范制度的密集和深入培训。

DESCRIPTION (provided by applicant): The primary objective of the proposed 2.5 week course is to provide state-of-the-art training in modern and emerging experimental approaches to study the nervous system of a major invertebrate model system, Drosophila melanogaster. The course on Drosophila Neurobiology: Genes, Circuits & Behavior is designed to introduce students to a wide variety of topics and techniques, including the latest approaches to study fly nervous system development, connectivity and behavior. Daily research seminars present comprehensive overviews of specific subfields of nervous system function and behavior, or focus on specific techniques and approaches to study diverse aspects of fly neurobiology. The course takes full advantage of the genetics of the fly as an experimental system for analyzing neural development, neuronal physiology and behavior. The course emphasizes the relevance of this powerful model system to advancing our understanding of the function and dysfunction of human brain. Instructors are chosen on the basis of their contributions to and knowledge of the field, each instructor providing in-depth expertise in a specific area that complements the others. In turn, the instructors invite lecturers who have made significant contributions in their fields t give up- to-the-minute reports on current research. The trainees are chosen by the course faculty from larger pools of applicants and range from advanced graduate students to principal investigators. Because of the short duration of the courses, senior as well as junior individuals can attend, and receive a short, intense period of training in an environment remote from other demands on their time and attention. This neurobiology laboratory course also provide an unusual opportunity for scientists to come up to speed in an advanced invertebrate model within neuroscience and to apply the concepts and techniques they learn to their own research interests. The course makes particular efforts to include a diverse group of participants, being particularly mindful of the inclusion of women, US minorities and a good balance of national and international scientists. PUBLIC HEALTH RELEVANCE: For more than a hundred years, the fruit fly Drosophila melanogaster has proved a powerful tool in helping scientists to understand how genetics works in animals. In the last couple of decades, the ability to rapidly breed and mutate these little flis has been used to shed light on the structure and function of the fly brain. Sophisticated genetic experiments have provided considerable information on the genes and molecules that are important in helping to build the brain, on the neuronal circuits and connectivity that form the brain's anatomy, and on the complex behaviors that are encoded within that anatomy. Furthermore, the model system can help us understand how these molecules, circuits and behaviors are altered or influenced as the animal adapts to and learns about new environments, how neuronal damage and/or loss leads to disease, and how brain function can be altered upon exposure to chemicals implicated in environmental perturbation or addiction. Understanding how these systems work in Drosophila has enormous relevance to our efforts to elucidate how these things function in higher animals, with consequences including how we think about neurological disease, brain evolution and other major themes of research in humans including alcohol and drug abuse. The proposed short course aims to provide intense and in-depth training in this important model system to advanced students and established investigators.