MAINTENANCE OF MASS SPECTROMETERS & LAB INSTRUMENTATION

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 在1.渗透式STR反射式MALDI飞行时间质谱仪上进行的仪器维护 2.Thermo-Finnigan LTQ电喷雾电离离子陷阱质谱仪，配有在线高效液相色谱和ETD裂解装置。 3.配备真空MALDI离子源的Thermo-Finnigan LTQ离子陷阱质谱仪。 *4.Finnigan LCQ-DECA-XP电喷雾电离离子陷阱质谱仪，配有内部建造的MALDI离子源，并带有我们的Cd样品进样系统。 5.Finnigan LCQ-DECA电喷雾电离离子陷阱质谱仪，配有在线微流色谱分离装置。 6.Waters Synapt离子迁移率四极飞行时间质谱仪 *7.新型高容量离子陷阱-四极串联质谱计样机，适用于配备有我们的自动Cd样品进样系统的内部构造的MALDI离子源的原型机Sciex QQTOF质谱仪。 8.Perkin Elmer ProTOF正交进样质谱仪 9.芬尼根ETD-LTQ-Orbitrap质谱仪 10.Pharmacia-amersham智能高效液相系统 11.LC填充液相色谱系统 12.微科科技XtremeSimple高效液相色谱系统。 13两套安捷伦高效液相色谱系统 质谱仪的服务包括维护真空泵、清洗离子源、更换离子探测器、维修电子设备；高效液相系统需要维护活塞和注射泵以及更换密封件、止回阀和故障排除。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Instrument maintenance performed on the 1. Perseptive STR reflectron MALDI time-of-flight mass spectrometer 2. Thermo-Finnigan LTQ electrospray ionization ion trap mass spectrometer fitted with on-line HPLC, and ETD fragmentation facility. 3. Thermo-Finnigan LTQ ion trap mass spectrometer fitted with a vacuum MALDI ion source. *4. Finnigan LCQ-DECA-XP electrospray ionization ion trap mass spectrometer fitted with an in-house constructed MALDI ion source incorporating our CD sample inlet system. 5. Finnigan LCQ-DECA electrospray ionization ion trap mass spectrometer fitted with an on-line microflow HPLC separation unit. 6. Waters Synapt Ion mobility Quadrupole Time-of-Flight Mass Spectrometer *7. Prototype novel high-capacity ion trap-quadrupole tandem mass spectrometer fitted to a prototype Sciex QQTOF mass spectrometer fitted with an in-house constructed MALDI ion source incorporating our automated CD sample inlet system. 8. Perkin Elmer ProTOF orthogonal Injection Mass Spectrometer 9. Finnigan ETD-LTQ-Orbitrap Mass Spectrometer 10. Pharmacia-Amersham Smart HPLC system 11. LC Packings HPLC system 12. Micro-Tech Scientific XtremeSimple HPLC system. 13 Two Agilent HPLC systems Service in the mass spectrometers included maintenance of vacuum pumps, cleaning of the ion source, replacement of ion detectors, repair of electronics; the HPLC systems required maintenance of piston and syringe pumps and replacement of seals, check valves, and trouble shooting.