SC COBRE FOR DEVELOPMENTALLY BASED CARDIOVASCULAR DISEASES

致力于指导、强有力的外部审查、坚实的核心实验室支持、连贯的主题和 挑选合格的候选人标志着科布雷在心血管领域的最初5年的支持 南卡罗来纳医科大学和南卡罗来纳大学的发展和疾病。 我们在9个目标教员中有6个的职业发展记录，153篇发表的期刊文章，书籍和 摘要和Cobre参与者的121个演示文稿记录了我们的成功。科布雷基金也 直接促成了9个额外的教师招聘，特别是包括一名少数族裔科学家。科布雷 方案发展综合机构基金(以种子赠款的形式)提供了7 具有关键资源的额外初级教员调查人员。此次续订充分利用了原始版本的优势 计划转向更具挑战性的目标-在 心血管发育生物学的科学主题，我们将其定义为：(1)正常和 发育异常；(2)成人心血管疾病的发育基础；(3)应用 发育生物学(再生医学)。面积超过11,000平方英尺(约合30平方米)。的实验室空间都致力于我们的 科布雷赞助中心心血管发育生物学中心(CDBC)。我们已经确认了四个 有才华的年轻调查人员将成为此次续签申请的目标教员，并描述计划 招募第五名。分配给我们科布雷中心的捐赠教席将使我们有可能招聘一名 优秀的资深科学家提供额外的科学领导和规划开发。我们的 续订计划继续强调最初资金期的成功战略，并增加计划 加强目标教职员工、高级科学人员之间富有成效的合作的要素 研究人员、核心实验室主任和临床医生(特别是儿科心脏病学)。这两种技术的结合 心血管发育生物学和再生医学研究在南加州大学和新加坡大学得到支持 这个Cobre是独一无二的，具有内在的翻译性；我们相信它将为其他机构提供一个模式。 本建议书描述了为PPG和SCCOR的开发建立有效的科学团队的计划 在P20筹资周期后维持CDBC的应用，同时加强心血管 发展和再生医学科学界在我们机构和全国。

Commitment to mentorship, strong external review, solid core laboratory support, a cohesive theme and selection of worthy candidates marked the initial 5 years of support for the COBRE in Cardiovascular Development and Disease at the Medical University of South Carolina and the University of South Carolina. Our record of career advancement for 6 of 9 targeted faculty, 153 published journal articels, books and abstracts, and 121 presentations by COBRE participants documents our success. COBRE funding also directly contributed to 9 additional faculty recruitments, notably including one minority scientist. COBRE support from combined institutional funds for program development (in the form of seed grants) provided 7 additional junior faculty investigators with key resources. This renewal leverages the strengths of the original program to a more challenging goal - the building of competitive program grant applications within the scientific theme of cardiovascular developmental biology, which we define as (1) mechanisms of normal and abnormal development, (2) the developmental basis of adult cardiovascular diseases and (3) applied developmental biology (regenerative medicine). Over 11,000 sq.ft. of laboratory space are dedicated to our COBRE sponsored center Cardiovascular Developmental Biology Center (CDBC). We have identified four talented young investigators to be the targeted faculty of this renewal application and describe plans to recruit a fifth. An endowed chair allocated to our COBRE center will make it possible to recruit an outstanding senior scientist to provide additional scientific leadership and programmatic development. Our renewal program continues to stress the successful strategies of the initial funding period and adds program elements to enhance productive collaboration between target faculty members, senior scientific investigators, core laboratory directors, and clinicians (especially pediatric cardiology). The combination of cardiovascular developmental biology and regenerative medicine investigation supported at MUSC and in this COBRE is unique and inherently translational; we believe it will provide a model for other institutions. This proposal describes plans for building effective scientific teamwork for development of PPG and SCCOR applications that will sustain the CDBC beyond the P20 funding cycle while strengthening the cardiovascular developmental and regenerative medicine scientific community at our institution and nationally.