SC COBRE FOR DEVELOPMENTALLY BASED CARDIOVASCULAR DISEASES

SC COBRE 针对发育性心血管疾病

• 批准号: 8264135
• 负责人: ROGER R MARKWALD
• 金额: $ 100万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8264135
• 关键词: SC; COBRE; DEVELOPMENTALLY; BASED; CARDIOVASCULAR

Commitment to mentorship, strong external review, solid core laboratory support, a cohesive theme and selection of worthy candidates marked the initial 5 years of support for the COBRE in Cardiovascular Development and Disease at the Medical University of South Carolina and the University of South Carolina. Our record of career advancement for 6 of 9 targeted faculty, 153 published journal articels, books and abstracts, and 121 presentations by COBRE participants documents our success. COBRE funding also directly contributed to 9 additional faculty recruitments, notably including one minority scientist. COBRE support from combined institutional funds for program development (in the form of seed grants) provided 7 additional junior faculty investigators with key resources. This renewal leverages the strengths of the original program to a more challenging goal - the building of competitive program grant applications within the scientific theme of cardiovascular developmental biology, which we define as (1) mechanisms of normal and abnormal development, (2) the developmental basis of adult cardiovascular diseases and (3) applied developmental biology (regenerative medicine). Over 11,000 sq.ft. of laboratory space are dedicated to our COBRE sponsored center Cardiovascular Developmental Biology Center (CDBC). We have identified four talented young investigators to be the targeted faculty of this renewal application and describe plans to recruit a fifth. An endowed chair allocated to our COBRE center will make it possible to recruit an outstanding senior scientist to provide additional scientific leadership and programmatic development. Our renewal program continues to stress the successful strategies of the initial funding period and adds program elements to enhance productive collaboration between target faculty members, senior scientific investigators, core laboratory directors, and clinicians (especially pediatric cardiology). The combination of cardiovascular developmental biology and regenerative medicine investigation supported at MUSC and in this COBRE is unique and inherently translational; we believe it will provide a model for other institutions. This proposal describes plans for building effective scientific teamwork for development of PPG and SCCOR applications that will sustain the CDBC beyond the P20 funding cycle while strengthening the cardiovascular developmental and regenerative medicine scientific community at our institution and nationally.

致力于指导、强有力的外部审查、坚实的核心实验室支持、有凝聚力的主题和 选择有价值的候选人标志着最初5年的支持COBRE在心血管 南卡罗来纳州医科大学和南卡罗来纳州大学的发展和疾病。 我们的9个目标教师中有6个的职业发展记录，153篇发表的期刊文章，书籍和 摘要和COBRE参与者的121个演示文稿记录了我们的成功。COBRE基金也 直接促成了另外9名教师的招聘，特别是包括一名少数民族科学家。Cobre 联合机构基金为方案发展提供支助（以种子赠款的形式）7 拥有关键资源的额外初级教师调查员。此次更新充分利用了原有 计划到一个更具挑战性的目标-竞争力的计划内的赠款申请建设 心血管发育生物学的科学主题，我们将其定义为（1）正常和 异常发育，（2）成人心血管疾病的发展基础和（3）应用 再生医学（Regenerative Medicine）超过11，000平方英尺的实验室空间致力于我们的 COBRE赞助的中心心血管发育生物学中心（CDBC）。我们已经确定了四个 有才华的年轻研究人员成为这一更新申请的目标教师，并描述计划， 招募第五名。分配给我们的COBRE中心的捐赠椅子将有可能招募一名 杰出的资深科学家提供额外的科学领导和方案发展。我们 更新计划继续强调最初资助期的成功战略，并增加了计划 要素，以加强目标教师，高级科学家， 研究者、核心实验室主任和临床医生（尤其是儿科心脏病学）。的组合 心血管发育生物学和再生医学研究在MUSC和 这个COBRE是独一无二的，具有内在的翻译性，我们相信它将为其他机构提供一个模型。 本提案描述了为开发PPG和SCCOR而建立有效科学团队的计划 这些应用将在P20资助周期之后维持CDBC，同时加强心血管 发展和再生医学科学界在我们的机构和国家。

项目成果

Scalable robotic biofabrication of tissue spheroids.

组织球体的可扩展机器人生物制造。

• DOI: 10.1088/1758-5082/3/2/025002
• 发表时间: 2011-06
• 期刊: Biofabrication
• 影响因子: 9
• 作者: Mehesz AN;Brown J;Hajdu Z;Beaver W;da Silva JV;Visconti RP;Markwald RR;Mironov V
• 通讯作者: Mironov V

Altered versican cleavage in ADAMTS5 deficient mice; a novel etiology of myxomatous valve disease.

• DOI: 10.1016/j.ydbio.2011.06.041
• 发表时间: 2011-09-01
• 期刊: Developmental biology
• 影响因子: 2.7
• 作者: Dupuis LE;McCulloch DR;McGarity JD;Bahan A;Wessels A;Weber D;Diminich AM;Nelson CM;Apte SS;Kern CB
• 通讯作者: Kern CB

Codistribution analysis of elastin and related fibrillar proteins in early vertebrate development.

早期脊椎动物发育中弹性蛋白和相关纤维蛋白的共分布分析。

• DOI: 10.1016/s0945-053x(03)00014-3
• 发表时间: 2003
• 期刊: Matrix biology : journal of the International Society for Matrix Biology
• 作者: Visconti,RichardP;Barth,JeremyL;Keeley,FredW;Little,CharlesD
• 通讯作者: Little,CharlesD

Second heart field-specific expression of Nkx2-5 requires promoter proximal interaction with Srf.

• DOI: 10.1016/j.mod.2020.103615
• 发表时间: 2020-06
• 期刊: Mechanisms of development
• 影响因子: 2.6
• 作者: Clark CD;Lee KH
• 通讯作者: Lee KH

Blood-borne stem cells differentiate into vascular and cardiac lineages during normal development.

血源性干细胞在正常发育过程中分化成血管和心脏谱系。

• DOI: 10.1089/scd.2006.15.17
• 发表时间: 2006
• 期刊: Stem cells and development.
• 作者: Zhang,Ning;Mustin,Deanna;Reardon,Wade;Almeida,AngelaDe;Mozdziak,Paul;Mrug,Michal;Eisenberg,LeonardM;Sedmera,David
• 通讯作者: Sedmera,David