SC COBRE FOR DEVELOPMENTALLY BASED CARDIOVASCULAR DISEASES

SC COBRE 针对发育性心血管疾病

• 批准号: 7874565
• 负责人: ROGER R MARKWALD
• 金额: $ 207.69万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7874565
• 关键词: SC; COBRE; DEVELOPMENTALLY; BASED; CARDIOVASCULAR

DESCRIPTION (provided by applicant): Commitment to mentorship, strong external review, solid Core laboratory support, a cohesive theme and selection of worthy candidates marked the initial 5 years of support for the COBRE in Cardiovascular Development and Disease at the Medical University of South Carolina and the University of South Carolina. Our record of career advancement for 6 of 9 targeted faculty, 153 published journal articels, books and abstracts, and 121 presentations by COBRE participants documents our success. COBRE funding also directly contributed to 9 additional faculty recruitments, notably including one minority scientist. COBRE support from combined institutional funds for program development (in the form of seed grants) provided 7 additional junior faculty investigators with key resources. This renewal leverages the strengths of the original program to a more challenging goal - the building of competitive program grant applications within the scientific theme of cardiovascular developmental biology, which we define as (1) mechanisms of normal and abnormal development, (2) the developmental basis of adult cardiovascular diseases and (3) applied developmental biology (regenerative medicine). Over 11,000 sq.ft. of laboratory space are dedicated to our COBRE sponsored center Cardiovascular Developmental Biology Center (CDBC). We have identified four talented junior investigators to be the targeted faculty of this renewal application and describe plans to recruit a fifth. An endowed chair allocated to our COBRE center will make it possible to recruit an outstanding senior scientist to provide additional scientific leadership and programmatic development. Our renewal program continues to stress the successful strategies of the initial funding period and adds program elements to enhance productive collaboration between target faculty members, senior scientific investigators, Core laboratory directors, and clinicians (especially pediatric cardiology). The combination of cardiovascular developmental biology and regenerative medicine investigation supported at MUSC and in this COBRE is unique and inherently translational; we believe it will provide a model for other institutions. This proposal describes plans for building effective scientific teamwork for development of PPG and SCCOR applications that will sustain the CDBC beyond the P20 funding cycle while strengthening the cardiovascular developmental and regenerative medicine scientific community at our institution and nationally.

描述（由申请人提供）：对导师的承诺，强有力的外部审查，坚实的核心实验室支持，有凝聚力的主题和有价值的候选人的选择标志着南卡罗来纳州医科大学和南卡罗来纳州大学对COBRE心血管发育和疾病的最初5年支持。我们的职业发展记录为6 9目标教师，153发表期刊文章，书籍和摘要，并由COBRE参与者121介绍文件我们的成功。COBRE的资金还直接促进了9名教师的招聘，特别是包括一名少数民族科学家。COBRE支持联合机构基金的计划发展（以种子赠款的形式）提供了7个额外的初级教师调查的关键资源。这次更新利用了原计划的优势，以实现更具挑战性的目标-在心血管发育生物学的科学主题内建立有竞争力的计划资助申请，我们将其定义为（1）正常和异常发育的机制，（2）成人心血管疾病的发展基础和（3）应用发育生物学（再生医学）。超过11，000平方英尺的实验室空间专用于我们的COBRE赞助的中心心血管发育生物学中心（CDBC）。我们已经确定了四个有才华的初级调查员是这个更新应用程序的目标教师，并描述了招聘第五个计划。分配给我们的COBRE中心的捐赠椅子将使我们有可能招募一位杰出的资深科学家，以提供额外的科学领导和计划发展。我们的更新计划继续强调初始资助期的成功策略，并增加计划元素，以加强目标教职员工，高级科学研究人员，核心实验室主任和临床医生（特别是儿科心脏病学）之间的有效合作。在MUSC和COBRE支持的心血管发育生物学和再生医学研究的结合是独特的和固有的翻译;我们相信它将为其他机构提供一个模型。该提案描述了建立有效的科学团队合作以开发PPG和SCCOR应用的计划，这些应用将在P20资助周期之后维持CDBC，同时加强我们机构和国家的心血管发育和再生医学科学界。