SC COBRE FOR DEVELOPMENTALLY BASED CARDIOVASCULAR DISEASES

描述(由申请人提供)：致力于指导，强有力的外部审查，坚实的核心实验室支持，连贯的主题和合格的候选人的选择标志着对南卡罗来纳医科大学和南卡罗来纳大学心血管发展和疾病科布雷项目的最初5年的支持。我们9名目标教师中有6名的职业发展记录、153篇发表的期刊文章、书籍和摘要，以及Cobre参与者的121份演示文稿记录了我们的成功。Cobre的资金还直接帮助额外招聘了9名教师，特别是包括一名少数族裔科学家。科布雷为项目发展(以种子资助的形式)提供的联合机构资金支持，为另外7名初级教职调查人员提供了关键资源。这一更新利用了原有计划的优势，实现了一个更具挑战性的目标--在心血管发展生物学的科学主题内建立竞争性计划拨款申请，我们将其定义为(1)正常和异常发育的机制，(2)成人心血管疾病的发育基础，以及(3)应用发展生物学(再生医学)。面积超过11,000平方英尺(约合30平方米)。所有的实验室空间都献给了我们科布雷赞助的心血管发育生物学中心(CDBC)。我们已经确定了四名有才华的初级调查人员作为这次续签申请的目标教员，并描述了招聘第五名的计划。分配给我们科布雷中心的一个捐赠教席将使我们有可能招募一名杰出的资深科学家来提供额外的科学领导和方案开发。我们的续订计划继续强调最初资助期的成功战略，并增加计划元素，以加强目标教员、高级科学研究人员、核心实验室主任和临床医生(特别是儿科心脏病学)之间的富有成效的合作。南加州大学心血管发育生物学和再生医学研究的结合是独一无二的，具有内在的转化性；我们相信它将为其他机构提供一个模式。该提案描述了为PPG和SCCOR应用程序的开发建立有效的科学团队的计划，这些应用程序将在P20供资周期后维持CDBC，同时加强我们机构和全国的心血管发展和再生医学科学界。

DESCRIPTION (provided by applicant): Commitment to mentorship, strong external review, solid Core laboratory support, a cohesive theme and selection of worthy candidates marked the initial 5 years of support for the COBRE in Cardiovascular Development and Disease at the Medical University of South Carolina and the University of South Carolina. Our record of career advancement for 6 of 9 targeted faculty, 153 published journal articels, books and abstracts, and 121 presentations by COBRE participants documents our success. COBRE funding also directly contributed to 9 additional faculty recruitments, notably including one minority scientist. COBRE support from combined institutional funds for program development (in the form of seed grants) provided 7 additional junior faculty investigators with key resources. This renewal leverages the strengths of the original program to a more challenging goal - the building of competitive program grant applications within the scientific theme of cardiovascular developmental biology, which we define as (1) mechanisms of normal and abnormal development, (2) the developmental basis of adult cardiovascular diseases and (3) applied developmental biology (regenerative medicine). Over 11,000 sq.ft. of laboratory space are dedicated to our COBRE sponsored center Cardiovascular Developmental Biology Center (CDBC). We have identified four talented junior investigators to be the targeted faculty of this renewal application and describe plans to recruit a fifth. An endowed chair allocated to our COBRE center will make it possible to recruit an outstanding senior scientist to provide additional scientific leadership and programmatic development. Our renewal program continues to stress the successful strategies of the initial funding period and adds program elements to enhance productive collaboration between target faculty members, senior scientific investigators, Core laboratory directors, and clinicians (especially pediatric cardiology). The combination of cardiovascular developmental biology and regenerative medicine investigation supported at MUSC and in this COBRE is unique and inherently translational; we believe it will provide a model for other institutions. This proposal describes plans for building effective scientific teamwork for development of PPG and SCCOR applications that will sustain the CDBC beyond the P20 funding cycle while strengthening the cardiovascular developmental and regenerative medicine scientific community at our institution and nationally.