SC COBRE FOR DEVELOPMENTALLY BASED CARDIOVASCULAR DISEASES

描述（由申请人提供）：承诺指导，强有力的外部审查，坚实的核心实验室支持，有凝聚力的主题和有价值的候选人的选择标志着南卡罗来纳医科大学和南卡罗来纳大学心血管发展和疾病COBRE最初5年的支持。我们对9名目标教师中的6名的职业发展记录，153篇发表的期刊文章，书籍和摘要，以及121篇COBRE参与者的演讲记录了我们的成功。COBRE的资金还直接促进了9名教员的招聘，其中包括一名少数族裔科学家。COBRE项目开发的联合机构资金支持（以种子基金的形式）为7名额外的初级教师调查员提供了关键资源。这一更新利用了原始项目的优势，以实现更具挑战性的目标——在心血管发育生物学的科学主题内建立竞争性项目资助申请，我们将其定义为(1)正常和异常发育的机制，(2)成人心血管疾病的发展基础，(3)应用发育生物学（再生医学）。超过11000平方英尺。我们的实验室空间专门用于COBRE赞助的中心心血管发育生物学中心（CDBC）。我们已经确定了四名有才华的初级研究人员作为本次更新申请的目标教员，并描述了招募第五名的计划。分配给我们COBRE中心的捐赠椅子将使招募一位杰出的资深科学家提供额外的科学领导和项目发展成为可能。我们的更新项目继续强调初始资助期的成功策略，并增加项目元素，以加强目标教员、高级科学研究者、核心实验室主任和临床医生（特别是儿科心脏病学）之间的富有成效的合作。心血管发育生物学和再生医学研究在MUSC和COBRE支持的组合是独特的和固有的翻译；我们相信这将为其他机构提供一个模式。本提案描述了为PPG和SCCOR应用的开发建立有效的科学团队的计划，这些团队将在P20资助周期之后维持CDBC，同时加强我们机构和全国的心血管发展和再生医学科学社区。

DESCRIPTION (provided by applicant): Commitment to mentorship, strong external review, solid Core laboratory support, a cohesive theme and selection of worthy candidates marked the initial 5 years of support for the COBRE in Cardiovascular Development and Disease at the Medical University of South Carolina and the University of South Carolina. Our record of career advancement for 6 of 9 targeted faculty, 153 published journal articels, books and abstracts, and 121 presentations by COBRE participants documents our success. COBRE funding also directly contributed to 9 additional faculty recruitments, notably including one minority scientist. COBRE support from combined institutional funds for program development (in the form of seed grants) provided 7 additional junior faculty investigators with key resources. This renewal leverages the strengths of the original program to a more challenging goal - the building of competitive program grant applications within the scientific theme of cardiovascular developmental biology, which we define as (1) mechanisms of normal and abnormal development, (2) the developmental basis of adult cardiovascular diseases and (3) applied developmental biology (regenerative medicine). Over 11,000 sq.ft. of laboratory space are dedicated to our COBRE sponsored center Cardiovascular Developmental Biology Center (CDBC). We have identified four talented junior investigators to be the targeted faculty of this renewal application and describe plans to recruit a fifth. An endowed chair allocated to our COBRE center will make it possible to recruit an outstanding senior scientist to provide additional scientific leadership and programmatic development. Our renewal program continues to stress the successful strategies of the initial funding period and adds program elements to enhance productive collaboration between target faculty members, senior scientific investigators, Core laboratory directors, and clinicians (especially pediatric cardiology). The combination of cardiovascular developmental biology and regenerative medicine investigation supported at MUSC and in this COBRE is unique and inherently translational; we believe it will provide a model for other institutions. This proposal describes plans for building effective scientific teamwork for development of PPG and SCCOR applications that will sustain the CDBC beyond the P20 funding cycle while strengthening the cardiovascular developmental and regenerative medicine scientific community at our institution and nationally.