Developmental

项目总结（见说明）： 发展资金被要求在战略需要的领域招募教师级科学家，以支持试点项目，使福克斯大通癌症中心的科学家在高优先级的研究领域追求创新的想法，并支持与中心的发现使命和战略目标相关的技术和方法开发项目。在上一个CCSG周期， 而且，除了我们的17名新成员外，23名新成员中的19名（83%）在任命后的24个月内获得了1540万美元的同行评审资金。此外，这个班成功地竞争了另外160万美元的竞争性基础支持。在上一个CCSG周期， 在第二年、第五年和第六年，主要由已建立的调查人员提供支助，以支持可能产生重大影响的项目。这12个获资助的项目已经产生了两个资助赠款和七个出版物。 在上一个CCSG周期中，该中心为高通量筛选设施提供了启动支持，该设施已成为16个已建立的共享设施之一。 在目前的CCSG申请中，我们寻求对25名新研究人员的部分支持，这些研究人员被确定为在下一个CCSG周期内满足该中心五个现有项目的临界质量需求所必需的。这一请求不到支助新调查员平均费用的25%。我们还寻求支持，每年为四个转化试点项目提供部分资金。这些CCSG基金将 与机构资金相匹配。最后，我们寻求部分资金用于技术开发和信息学计划，以支持该中心的个性化医疗研究所。所有这些发展基金都被认为是实现该中心战略计划中概述的发现目标的关键。

PROJECT SUMMARY (See instructions): Developmental funds are requested to recruit faculty level scientists in areas of strategic need, to support pilot projects that allow Fox Chase Cancer Center scientists to pursue innovative ideas in high priority research areas, and to support technology and methodology development projects related to the Center's discovery mission and strategic objectives. In the past CCSG cycle, 40 investigators were recruited and, with the exclusion of our 17 newest recruits, 19 of 23 (83%) have obtained $15.4 million in peer reviewed funding within 24 months of their appointment Of that amount $5.1 million was garnered by investigators directly leveraging developmental funds. Also, this class competed successfully for a further $1.6 million in competitive foundation support. During the last CCSG cycle, pilot project funds were utilized in the second, fifth and sixth years to support potential high-impact projects, largely from established investigators. The 12 funded projects have already produced two funded grants and seven publications. During the past CCSG cycle, the Center provided start up support for a High Throughput Screening Facility that has become one of the 16 established shared facilities. In the present CCSG application we seek partial support for the 25 new investigators identified as necessary to address the critical mass needs of the Center's five existing programs over the next CCSG cycle. This request represents less than 25% of the average cost of supporting a new investigator. We also seek support for partial funding for four translational pilot projects per year. These CCSG funds will be matched by institutional funds. Finally, we seek partial funding for technology developments and informatics initiatives in support of the Center's Institute for Personalized Medicine. All of these developmental funds are considered vital to achieving the discovery objectives outlined in the Center's Strategic Plan.