Developmental

发育性

• 批准号: 8335532
• 负责人: MICHAEL V. SEIDEN
• 金额: $ 34.54万
• 依托单位: FOX CHASE CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-21 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8335532
• 关键词: Address; Appointment; Area; Bioinformatics; Cancer Center; Cancer Center Support Grant; Clinical Investigator; Collaborations; Comprehensive Cancer Center; Development; Emerging Technologies; Epigenetic Process; Evaluation; Exclusion; Faculty; Foundations; Fox Chase Cancer Center; Foxes; Funding; Genomics; Grant; Growth; Informatics; Institutes; Instruction; Investigation; Laboratories; Medicine; Methodology; Mission; Peer Review; Pilot Projects; Positioning Attribute; Publications; Recruitment Activity; Research Personnel; Research Priority; Scientist; Strategic Planning; Technology; Translational Research; anticancer research; cost; high throughput screening; innovation; new technology; programs; technology development

PROJECT SUMMARY (See instructions): Developmental funds are requested to recruit faculty level scientists in areas of strategic need, to support pilot projects that allow Fox Chase Cancer Center scientists to pursue innovative ideas in high priority research areas, and to support technology and methodology development projects related to the Center's discovery mission and strategic objectives. In the past CCSG cycle, 40 investigators were recruited and, with the exclusion of our 17 newest recruits, 19 of 23 (83%) have obtained $15.4 million in peer reviewed funding within 24 months of their appointment Of that amount $5.1 million was garnered by investigators directly leveraging developmental funds. Also, this class competed successfully for a further $1.6 million in competitive foundation support. During the last CCSG cycle, pilot project funds were utilized in the second, fifth and sixth years to support potential high-impact projects, largely from established investigators. The 12 funded projects have already produced two funded grants and seven publications. During the past CCSG cycle, the Center provided start up support for a High Throughput Screening Facility that has become one of the 16 established shared facilities. In the present CCSG application we seek partial support for the 25 new investigators identified as necessary to address the critical mass needs of the Center's five existing programs over the next CCSG cycle. This request represents less than 25% of the average cost of supporting a new investigator. We also seek support for partial funding for four translational pilot projects per year. These CCSG funds will be matched by institutional funds. Finally, we seek partial funding for technology developments and informatics initiatives in support of the Center's Institute for Personalized Medicine. All of these developmental funds are considered vital to achieving the discovery objectives outlined in the Center's Strategic Plan.

项目摘要（参见说明）： 需要发展资金来招募战略需求领域的教师级科学家，支持试点项目，使福克斯蔡斯癌症中心的科学家能够在高优先级研究领域追求创新想法，并支持与该中心的发现使命和战略目标相关的技术和方法开发项目。在过去的 CCSG 周期中，招募了 40 名调查员 排除我们最新招募的 17 名员工，23 名员工中的 19 名（83%）在任命后 24 个月内获得了 1540 万美元的同行评审资金，其中 510 万美元是由调查人员直接利用发展基金获得的。此外，该班级还成功获得了另外 160 万美元的竞争性基金会支持。在上一个 CCSG 周期内，使用了试点项目资金 在第二年、第五年和第六年支持潜在的高影响力项目，这些项目主要来自现有的研究人员。这 12 个资助项目已经产生了两项资助赠款和七份出版物。 在过去的 CCSG 周期中，该中心为高通量筛选设施提供了启动支持，该设施已成为 16 个已建立的共享设施之一。 在当前的 CCSG 申请中，我们寻求对 25 名新调查员的部分支持，这些新调查员被确定为满足下一个 CCSG 周期内该中心五个现有项目的关键群体需求。该请求仅占支持新研究者平均成本的 25% 以下。我们每年还为四个转化试点项目寻求部分资金支持。这些 CCSG 资金将 机构资金与之配套。最后，我们寻求部分资金用于技术开发和信息学计划，以支持该中心的个性化医疗研究所。所有这些发展资金都被认为对于实现该中心战略计划中概述的发现目标至关重要。