Developmental

项目总结(见说明)： 发展基金被要求在战略需求领域招聘教职员工级别的科学家，支持试点项目，使福克斯大通癌症中心的科学家能够在高度优先的研究领域寻求创新想法，并支持与该中心的发现任务和战略目标相关的技术和方法开发项目。在过去的CCSG周期中，招募了40名调查人员 而且，不包括我们的17名最新招聘人员，23名中有19名(83%)在任命后24个月内获得了1540万美元的同行审查资金，其中510万美元是调查人员直接利用发展基金获得的。此外，这一课程还成功地争取到了另外160万美元的竞争基础支持。在最后一个CCSG周期中，利用了试点项目资金 在第二、第五和第六年支持潜在的高影响项目，主要来自现有的调查人员。这12个资助项目已经产生了两个资助赠款和七份出版物。 在过去的CCSG周期中，该中心为一个高吞吐量筛选设施提供了启动支持，该设施已成为16个已建立的共享设施之一。 在目前的CCSG申请中，我们寻求对25名新调查员的部分支持，这些新调查员被确定为必要的，以在下一个CCSG周期内满足中心现有五个项目的关键群众需求。这一请求不到支持一名新调查员的平均成本的25%。我们还为每年四个翻译试点项目寻求部分资金支持。这些CCSG基金将是 与之相匹配的是机构资金。最后，我们寻求为支持该中心个性化医学研究所的技术开发和信息学倡议提供部分资金。所有这些发展基金都被认为对实现中心战略计划中概述的发现目标至关重要。

PROJECT SUMMARY (See instructions): Developmental funds are requested to recruit faculty level scientists in areas of strategic need, to support pilot projects that allow Fox Chase Cancer Center scientists to pursue innovative ideas in high priority research areas, and to support technology and methodology development projects related to the Center's discovery mission and strategic objectives. In the past CCSG cycle, 40 investigators were recruited and, with the exclusion of our 17 newest recruits, 19 of 23 (83%) have obtained $15.4 million in peer reviewed funding within 24 months of their appointment Of that amount $5.1 million was garnered by investigators directly leveraging developmental funds. Also, this class competed successfully for a further $1.6 million in competitive foundation support. During the last CCSG cycle, pilot project funds were utilized in the second, fifth and sixth years to support potential high-impact projects, largely from established investigators. The 12 funded projects have already produced two funded grants and seven publications. During the past CCSG cycle, the Center provided start up support for a High Throughput Screening Facility that has become one of the 16 established shared facilities. In the present CCSG application we seek partial support for the 25 new investigators identified as necessary to address the critical mass needs of the Center's five existing programs over the next CCSG cycle. This request represents less than 25% of the average cost of supporting a new investigator. We also seek support for partial funding for four translational pilot projects per year. These CCSG funds will be matched by institutional funds. Finally, we seek partial funding for technology developments and informatics initiatives in support of the Center's Institute for Personalized Medicine. All of these developmental funds are considered vital to achieving the discovery objectives outlined in the Center's Strategic Plan.