A Laser Microbeam Biotechnology Resource

激光微束和医疗计划（LAMMP）是NIH生物医学技术资源中心 致力于激光和光学在生物学和医学中的应用。LAMMP位于Beckman 激光研究所（BLI），大学的跨学科生物医学研究，教学和临床设施 来自加州欧文市总的资源目标是促进中心在以下方面开展活动， 技术研究和开发、合作研究、服务、培训和传播。在这 在LAMMP的第六次续期申请中，我们继续强调我们独特的能力， “转化”研究，将基础科学和技术发现从“黑板”迅速转移到 benchtop到bedside床边”。这是通过将最先进的光学技术与 细胞和组织工程、组织病理学、临床前动物模型的专业资源设施，以及 临床护理 LAMMP提供显微镜和微束技术（MMT）， 活细胞和组织的成像和操作，以及 无创和微创监测、治疗和成像临床前动物模型和人 科目此外，我们建议建立一个新的核心，虚拟光子技术（VPT）， 开发提高生物光子技术性能的计算模型和方法， 并增强从光学测量得到的信息内容。七、技术研究与开发 提出的发展项目将导致制造几种新的仪器， 创建多功能软件。这些项目建立在我们长期以来在光组织方面的专业知识基础上 相互作用模型和生物光子学技术，包括激光微束，非线性显微镜， 光学相干层析成像、空间/时间调制方法和漫射光学。 LAMMP核心包含能够定量表征的补充技术， 以可缩放的分辨率对细胞和组织中的结构和生化功能进行成像和扰动， 深度灵敏度范围从微米到厘米。建议开展合作研究， 这些技术使它们变得广泛可用，使生物学和医学方法成为可能。在整个 我们强调LAMMP技术在癌症等领域与医学的相关性， 心血管疾病、代谢综合征和神经功能，以及基本的 生物过程，如机械转导、伤口修复、血管生成、纤维化和细胞死亡。

The Laser Microbeam and Medical Program (LAMMP) is a NIH Biomedical Technology Resource Center dedicated to the use of lasers and optics in biology and medicine. LAMMP is located within the Beckman Laser Institute (BLI), an interdisciplinary biomedical research, teaching, and clinical facility at the University of California, Irvine. Overall resource objectives are to promote a well-balanced Center with activities in technological research and development, collaborative research, service, training, and dissemination. In this sixth renewal application of LAMMP, we continue to emphasize our unique capabilities to facilitate "translational" research by rapidly moving basic science and technology discoveries from "blackboard to benchtop to bedside". This is accomplished by combining state of the art optical technologies with specialized resource facilities for cell and tissue engineering, histopathology, pre-clinical animal models, and clinical care. LAMMP provides both Microscopy and Microbeam Technologies (MMT) for high-resolution functional imaging and manipulation of living cells and tissues and Medical Translational Technologies (MTT) for non- and minimally-invasive monitoring, treating, and imaging pre-clinical animal models and human subjects. In addition, we propose to establish a new core, Virtual Photonics Technologies (VPT) for developing computational models and methods that advance the performance of biophotonic technologies, and enhance the information content derived from optical measurements. Seven Technology Research and Development projects are proposed that will result in the fabrication of several new instruments as well as the creation of multi-functional software. These projects build on our longstanding expertise in light-tissue interaction models and Biophotonics technologies, including laser microbeams, non-linear microscopy, optical coherence tomography, spatial/temporal modulation methods, and diffuse optics. LAMMP cores contain complementary technologies that are capable of quantitatively characterizing, imaging, and perturbing structure and biochemical function in cells and tissues with scalable resolution and depth sensitivity ranging from micrometers to centimeters. Collaborative studies are proposed that advance these technologies so they become widely-available, enabling methods in Biology and Medicine. Throughout the grant we emphasize the relevance of LAMMP technologies to Medicine in areas such as cancer, cardiovascular disease, metabolic syndrome, and neurologic function, as well as fundamental biological process, such as mechano-transduction, wound repair, angiogenesis, fibrosis, and cell death.