ShEEP Request for Scintica Flow Velocity and Oxygen System

ShEEP 请求 Scintica 流速和氧气系统

• 批准号: 9794630
• 负责人: Hemal H Patel
• 金额: --
• 依托单位: VA SAN DIEGO HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-01 至 2019-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9794630
• 关键词: Acute; Address; Area; Award; Blood Flow Velocity; Blood Vessels; Blood flow; Brain; Brain Neoplasms; Collaborations; Coupled; Data; Data Analyses; Diabetes Mellitus; Disease; Echocardiography; Equipment; Erectile dysfunction; Fatty Liver; Fostering; Functional disorder; Funding; Health; Healthcare Systems; Heart; Heart failure; Homeostasis; Intervention; Kidney; Liver; Malignant Neoplasms; Measurement; Measures; Medical; Monitor; Mus; Muscle; Muscular Atrophy; Myocardial Ischemia; Neurodegenerative Disorders; Organ; Organism; Oryctolagus cuniculus; Oxygen; Pain; Pathology; Pharmacology; Physiologic pulse; Physiology; Population; Rattus; Research Personnel; Sheep; Structure; System; Techniques; Time; Tissues; Veterans; body system; burden of illness; clinical investigation; imaging modality; innovation; insight; interest; non-invasive imaging; novel; pre-clinical; resilience; response; sensor; tool

Project Summary/Abstract Medical techniques are widely used for pre-clinical investigations. These non-invasive imaging modalities are crucial for researchers to observe changes in organ/tissue structure, size, and blood flow during disease stages as well as in response to pharmacological interventions. The requested equipment is a system for flow velocity and oxygen measurement (Scintica Flow Velocity and Oxygen System) that will interface with our current echocardiographic system (Vevo3100, FUJIFILM, VisualSonics) funded previously by a ShEEP award for use in mice, rats, and rabbits. The Flow Velocity Oxygen System will be equipped with a real-time pulsed doppler acquisition and data analysis tool coupled to oxygen sensors that can measure tissue oxygen and oxygen flow and will allow a range of species to be used in conjunction with the current Vevo3100 echocardiographic system. As all organs are dependent on reliable blood flow and oxygen delivery and usage for proper function and that these aspects of homeostasis are often altered in various diseases states that impact the heart, brain, kidney, liver, and muscle, the blood flow and oxygen system will enhance the capabilities of multiple groups at the VA San Diego to assess these important parameters specific to their studies. The functionality of this novel Flow Velocity and Oxygen System will allow a large and prolific group of VA San Diego Healthcare System (VASDHS) investigators working in multiple systems the opportunity to expand their experimental capabilities dramatically and to foster new collaboration.

项目摘要/摘要 医学技术被广泛用于临床前研究。这些非侵入性成像 对于研究人员来说，观察器官/组织结构、大小和血液的变化是至关重要的 在疾病阶段以及对药物干预的反应中流动。 所要求的设备是流速和氧气测量系统(Scintica Flow 速度和氧气系统)，将与我们目前的超声心动图系统接口 (Vevo3100，Fujifilm，Visualsonics)之前由绵羊奖资助，用于小鼠、大鼠和 兔子。 流动速度氧气系统将配备实时脉冲多普勒采集和 与氧传感器耦合的数据分析工具，可以测量组织氧和氧气流量，并 将允许一系列物种与当前的Vevo3100超声心动图一起使用 系统。因为所有的器官都依赖于可靠的血流和氧气的输送和适当的使用 功能和这些方面的动态平衡经常改变在各种疾病状态 影响心脏、大脑、肾脏、肝脏和肌肉，血液流动和氧气系统将增强 退伍军人事务部圣地亚哥分校的多个小组评估这些特定于 他们的研究。 这一新的流速和氧气系统的功能将允许大量和多产的 弗吉尼亚州圣地亚哥医疗系统(VASDHS)调查人员在多个系统工作 有机会极大地扩展他们的实验能力并促进新的协作。