ShEEP Request for Scintica Flow Velocity and Oxygen System

项目总结/摘要 医疗技术广泛用于临床前研究。这些非侵入性成像 对于研究人员来说，观察器官/组织结构、大小和血液的变化至关重要 在疾病阶段以及对药物干预的反应中流动。 所要求的设备是用于流速和氧气测量的系统（Scintica Flow 速度和氧气系统），将与我们目前的超声心动图系统接口 （Vevo 3100，FUJIFILM，VisualSonics），之前由ShEEP奖资助，用于小鼠、大鼠和 家兔 流速氧气系统将配备实时脉冲多普勒采集， 与氧传感器耦合的数据分析工具，所述氧传感器可以测量组织氧和氧流量， 将允许一系列物种与当前的Vevo 3100超声心动图结合使用 系统由于所有器官都依赖于可靠的血流和氧气输送和使用， 功能，这些方面的稳态往往改变了各种疾病状态， 影响心脏，大脑，肾脏，肝脏和肌肉，血液流动和氧气系统将增强 弗吉尼亚州圣地亚哥的多个小组评估这些重要参数的能力， 他们的研究 这种新型流速和氧气系统的功能将允许大量多产的 VA圣地亚哥医疗保健系统（VASDHS）调查人员在多个系统中工作， 有机会大大扩大他们的实验能力，并促进新的合作。

Project Summary/Abstract Medical techniques are widely used for pre-clinical investigations. These non-invasive imaging modalities are crucial for researchers to observe changes in organ/tissue structure, size, and blood flow during disease stages as well as in response to pharmacological interventions. The requested equipment is a system for flow velocity and oxygen measurement (Scintica Flow Velocity and Oxygen System) that will interface with our current echocardiographic system (Vevo3100, FUJIFILM, VisualSonics) funded previously by a ShEEP award for use in mice, rats, and rabbits. The Flow Velocity Oxygen System will be equipped with a real-time pulsed doppler acquisition and data analysis tool coupled to oxygen sensors that can measure tissue oxygen and oxygen flow and will allow a range of species to be used in conjunction with the current Vevo3100 echocardiographic system. As all organs are dependent on reliable blood flow and oxygen delivery and usage for proper function and that these aspects of homeostasis are often altered in various diseases states that impact the heart, brain, kidney, liver, and muscle, the blood flow and oxygen system will enhance the capabilities of multiple groups at the VA San Diego to assess these important parameters specific to their studies. The functionality of this novel Flow Velocity and Oxygen System will allow a large and prolific group of VA San Diego Healthcare System (VASDHS) investigators working in multiple systems the opportunity to expand their experimental capabilities dramatically and to foster new collaboration.