Multifunctional Regualtion of Angiogenesis by High Density Lipoproteins

高密度脂蛋白对血管生成的多功能调节

• 批准号: nhmrc : 632512
• 负责人: A/Pr Martin Ng
• 金额: $ 32.05万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/multifunctional-regualtion-angiogenesis-density-lipoproteins/95660
• 关键词: Multifunctional; Regualtion; Angiogenesis; Density; Lipoproteins

For many sufferers of heart disease and cancer, current treatments do not relieve the debilitating symptoms. The growth of new blood vessels can alleviate the effects of a restricted blood supply, caused by blocked arteries. Conversely, new vessel growth accelerates some diseases such as cancer. HDL is one of the main forms of cholesterol in the blood. Recently we identified a beneficial bifunctional role for HDL in vessel growth. This project will investigate the mechanisms for these effects.

对于许多心脏病和癌症患者来说，目前的治疗方法并不能缓解使人衰弱的症状。新血管的生长可以缓解由动脉阻塞引起的血液供应受限的影响。相反，新血管的生长会加速某些疾病的发生，比如癌症。高密度脂蛋白是血液中胆固醇的主要形式之一。最近，我们发现HDL在血管生长中具有有益的双重作用。这个项目将研究这些影响的机制。