The Role of the Thioredoxin System in Angiogenesis and Impaired Neovascularisation in Diabetes Mellitus

硫氧还蛋白系统在糖尿病血管生成和新血管形成受损中的作用

• 批准号: nhmrc : 512299
• 负责人: A/Pr Martin Ng
• 金额: $ 20.44万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-thioredoxin-angiogenesis-diabetes-mellitus/97965
• 关键词: Role; Thioredoxin; System; Angiogenesis; Impaired

For many sufferers of heart disease who suffer from blocked coronary arteries, current treatments (e.g. bypass surgery or angioplasty) are unable to offer relief from the debilitating effects of occluded arteries. This is particularly true of patients with diabetes who have more aggressive blockages. We plan to study a newly identified mechanism to facilitate growth of new blood vessels to sites affected by vascular disease . Ultimately, this may result in new treatments for heart disease.

对于许多患有冠状动脉阻塞的心脏病患者，目前的治疗方法（如搭桥手术或血管成形术）无法缓解动脉闭塞的衰弱影响。糖尿病患者尤其如此，因为他们的血管阻塞更严重。我们计划研究一种新发现的机制，以促进新血管生长到受血管疾病影响的部位。最终，这可能会导致心脏病的新疗法。