The critical roles of heme oxygenase-1 in the response to ischemia

血红素加氧酶-1 在缺血反应中的关键作用

• 批准号: nhmrc : 1050776
• 负责人: A/Pr Martin Ng
• 金额: $ 46.05万
• 依托单位: Victor Chang Cardiac Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/critical-roles-heme-response-ischemia/112178
• 关键词: critical; roles; heme; oxygenase; response

Heme oxygenase-1 is a protein that recycles our body's iron which itself is essential for life because it is needed for the sensing, transport and use of oxygen we breath. The current project investigates a novel interplay between heme oxygenase-1 and our body’s major response to tissue oxygen becoming limited. By doing so, our project may provide the basis for novel treatments of conditions where arteries are obstructed, such as those that lead to heart attack and amputation.

血红素氧合酶-1是一种蛋白质，它可以分解我们身体中的铁，而铁本身对生命至关重要，因为它是我们呼吸的氧气的感知，运输和使用所必需的。目前的项目调查血红素加氧酶-1和我们的身体的主要反应组织氧变得有限之间的一种新的相互作用。通过这样做，我们的项目可能为动脉阻塞的新治疗方法提供基础，例如导致心脏病发作和截肢的疾病。