核心 C - HDL 定量-猫眼课题宝

核心 C - HDL 定量

批准号：

9353451

负责人：

Tomas Vaisar

金额：

$54.25万

依托单位：

VANDERBILT UNIVERSITY MEDICAL CENTER

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/9353451

关键词：

Area Bioinformatics Biological Biological Assay Complex Data Data Set Databases Electrospray Ionization Genes Goals High Density Lipoproteins Human Resources Individual Isotopes Laboratories Lipoproteins Liquid Chromatography Mass Spectrum Analysis Measurement Methods Molecular Ontology Particle Size Pathway Analysis Peptides Phosphatidylcholine-Sterol O-Acyltransferase Program Research Project Grants Proteins Proteome Proteomics Recombinants Research Research Personnel Services Shotguns Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Standardization Structural Models Structure Technology Testing Time analytical method analytical tool cost effectiveness crosslink instrumentation interdisciplinary approach interest ion mobility mutant particle protein protein interaction reconstitution tandem mass spectrometry tool two-dimensional

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中文摘要

翻译

对HDL感兴趣的生物医学研究人员的一个关键目标是建立结构之间的关系，和脂蛋白的功能。HDL定量核心将提供强大的质谱分析工具以及HDL颗粒大小和浓度的定量。核心人员有在这些领域有记录的专业知识，他们的能力将支持PPG调查人员提供标准化，经验证的一组常用测定。核心C还将优化效率和成本效益，中心实验室的服务。

英文摘要

A key goal of biomedical investigators interested in HDL is to establish the relationships between the structure and function of the lipoprotein. The HDL Quantitation Core will provide the powerful tools of mass spectrometry and quantification of HDL particle size and concentration to PPG investigators. Core personnel have documented expertise in these areas, and their capabilities will support PPG investigators with a standardized, validated set of common assays. Core C will also optimize efficiency and cost-effectiveness by providing these services in a central laboratory.

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