Core C - HDL Quantitation

核心 C - HDL 定量

• 批准号: 9073918
• 负责人: Tomas Vaisar
• 金额: $ 55.7万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-15 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9073918
• 关键词: Area; Bioinformatics; Biological; Biological Assay; Complex; Data; Data Set; Databases; Electrospray Ionization; Genes; Goals; High Density Lipoproteins; Human Resources; Individual; Isotopes; Laboratories; Lipoproteins; Liquid Chromatography; Mass Spectrum Analysis; Measurement; Methods; Molecular; Ontology; Particle Size; Pathway Analysis; Peptides; Phosphatidylcholine-Sterol O-Acyltransferase; Program Research Project Grants; Proteins; Proteome; Proteomics; Recombinants; Research; Research Personnel; Services; Shotguns; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Structural Models; Structure; Technology; Testing; Time; analytical method; analytical tool; cost effectiveness; crosslink; instrumentation; interdisciplinary approach; interest; ion mobility; mutant; particle; protein protein interaction; reconstitution; tandem mass spectrometry; tool; two-dimensional

A key goal of biomedical investigators interested in HDL is to establish the relationships between the structure and function of the lipoprotein. The HDL Quantitation Core will provide the powerful tools of mass spectrometry and quantification of HDL particle size and concentration to PPG investigators. Core personnel have documented expertise in these areas, and their capabilities will support PPG investigators with a standardized, validated set of common assays. Core C will also optimize efficiency and cost-effectiveness by providing these services in a central laboratory.

对HDL感兴趣的生物医学研究人员的一个关键目标是建立结构之间的关系， 和脂蛋白的功能。HDL定量核心将提供强大的质谱分析工具 以及HDL颗粒大小和浓度的定量。核心人员有 在这些领域有记录的专业知识，他们的能力将支持PPG调查人员提供标准化， 经验证的一组常用测定。核心C还将优化效率和成本效益， 中心实验室的服务。