Epidemiological analysis of two interstitial cystitis cohorts

两个间质性膀胱炎队列的流行病学分析

基本信息

  • 批准号:
    10438514
  • 负责人:
  • 金额:
    $ 82.92万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-09-01 至 2024-08-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY/ABSTRACT Interstitial cystitis/bladder pain syndrome (IC/BPS) is a multifactorial, chronic syndrome involving urinary frequency, urinary urgency, and bladder discomfort (1) that affects an estimated 10 million patients in the United States(2). Although understandings of IC/BPS pathophysiology remain limited, published studies have found several comorbidities, including vulvodynia and anxiety comorbidities prevalent in IC/BPS (4, 5). Research suggests that these comorbidities, in turn, exacerbate IC/BPS symptoms and are associated with poor functioning, adjustment, prognosis, and treatment response rates. The research within this proposal builds upon our previous analyses and those of the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. Our cohort of 400 IC/BPS patients at Boston Children's Hospital has been followed for 15 years and provides an extraordinary opportunity for an epidemiological study of the various conditions co-occurring with IC/BPS. We will also comprehensively phenotype a large online cohort of patients with IC/BPS through surveys and systematic analysis of patient social media posts via “social listening”, which could be methodologically advantageous in identifying environmental factors when triangulated with patient surveys influencing IC/BPS comorbidities. The hypothesis underlying this proposal is that extensive phenotyping will elucidate the depth and breadth of co-occurring disorders in IC/BPS and uncover factors that play a role in the development of the disorders. Based on this hypothesis, our aims are to: 1) identify the prevalence of conditions in demographically distinct cohorts (e.g, anxiety, depression, vulvodynia) and potential environmental influencers (e.g., family discord, poverty, pollution); 2) comprehensively and rigorously phenotype a subset of these patients with the use of PROMIS and PhenX toolkit surveys for comorbid conditions; and 3) characterize the impact of health disparities on IC/BPS, with particular attention paid to health disparities affecting African Americans with IC/BPS. As this project leverages existing cohorts and conducts phenotyping via telemedicine, it is a cost-effective approach to better characterizing phenotypes and elucidating the architecture and epidemiology of dimensional phenotypes in IC/BPS.
项目总结/文摘

项目成果

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Catherine Astrid Brownstein其他文献

Catherine Astrid Brownstein的其他文献

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{{ truncateString('Catherine Astrid Brownstein', 18)}}的其他基金

Navigating Online Patient Experiences of Genomic Medicine: Identifying and Overcoming Obstacles for African American Communities
引导基因组医学在线患者体验:识别和克服非裔美国人社区的障碍
  • 批准号:
    10228319
  • 财政年份:
    2021
  • 资助金额:
    $ 82.92万
  • 项目类别:
Epidemiological analysis of two interstitial cystitis cohorts
两个间质性膀胱炎队列的流行病学分析
  • 批准号:
    10330743
  • 财政年份:
    2021
  • 资助金额:
    $ 82.92万
  • 项目类别:
Epidemiological analysis of two interstitial cystitis cohorts
两个间质性膀胱炎队列的流行病学分析
  • 批准号:
    10618342
  • 财政年份:
    2021
  • 资助金额:
    $ 82.92万
  • 项目类别:
Navigating Online Patient Experiences of Genomic Medicine: Identifying and Overcoming Obstacles for African American Communities
引导基因组医学在线患者体验:识别和克服非裔美国人社区的障碍
  • 批准号:
    10469319
  • 财政年份:
    2021
  • 资助金额:
    $ 82.92万
  • 项目类别:

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