Epidemiological analysis of two interstitial cystitis cohorts

两个间质性膀胱炎队列的流行病学分析

• 批准号: 10618342
• 负责人: Catherine Astrid Brownstein
• 金额: $ 82.92万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10618342
• 关键词: Epidemiological; analysis; two; interstitial; cystitis

PROJECT SUMMARY/ABSTRACT Interstitial cystitis/bladder pain syndrome (IC/BPS) is a multifactorial, chronic syndrome involving urinary frequency, urinary urgency, and bladder discomfort (1) that affects an estimated 10 million patients in the United States(2). Although understandings of IC/BPS pathophysiology remain limited, published studies have found several comorbidities, including vulvodynia and anxiety comorbidities prevalent in IC/BPS (4, 5). Research suggests that these comorbidities, in turn, exacerbate IC/BPS symptoms and are associated with poor functioning, adjustment, prognosis, and treatment response rates. The research within this proposal builds upon our previous analyses and those of the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. Our cohort of 400 IC/BPS patients at Boston Children's Hospital has been followed for 15 years and provides an extraordinary opportunity for an epidemiological study of the various conditions co-occurring with IC/BPS. We will also comprehensively phenotype a large online cohort of patients with IC/BPS through surveys and systematic analysis of patient social media posts via “social listening”, which could be methodologically advantageous in identifying environmental factors when triangulated with patient surveys influencing IC/BPS comorbidities. The hypothesis underlying this proposal is that extensive phenotyping will elucidate the depth and breadth of co-occurring disorders in IC/BPS and uncover factors that play a role in the development of the disorders. Based on this hypothesis, our aims are to: 1) identify the prevalence of conditions in demographically distinct cohorts (e.g, anxiety, depression, vulvodynia) and potential environmental influencers (e.g., family discord, poverty, pollution); 2) comprehensively and rigorously phenotype a subset of these patients with the use of PROMIS and PhenX toolkit surveys for comorbid conditions; and 3) characterize the impact of health disparities on IC/BPS, with particular attention paid to health disparities affecting African Americans with IC/BPS. As this project leverages existing cohorts and conducts phenotyping via telemedicine, it is a cost-effective approach to better characterizing phenotypes and elucidating the architecture and epidemiology of dimensional phenotypes in IC/BPS.

项目概要/摘要 间质性膀胱炎/膀胱疼痛综合征（IC/BPS）是一种多因素、慢性综合征，涉及泌尿系统。 尿频、尿急和膀胱不适 (1) 影响了估计 1000 万患者 美国(2)。尽管对 IC/BPS 病理生理学的理解仍然有限，但已发表的研究 已发现多种合并症，包括 IC/BPS 中普遍存在的外阴痛和焦虑合并症 (4, 5)。 研究表明，这些合并症反过来会加剧 IC/BPS 症状，并与 功能、调整、预后和治疗反应率较差。 本提案中的研究建立在我们之前的分析和多学科的分析的基础上 慢性盆腔疼痛 (MAPP) 研究网络的研究方法。我们的 400 IC/BPS 队列 波士顿儿童医院的患者已被追踪 15 年，并提供了非凡的治疗效果 对与 IC/BPS 同时发生的各种病症进行流行病学研究的机会。 我们还将通过调查对大量在线 IC/BPS 患者进行全面表型分析 通过“社交聆听”对患者社交媒体帖子进行系统分析，这可以 当与患者进行三角测量时，在识别环境因素方面具有方法学上的优势 影响 IC/BPS 合并症的调查。 该提议的假设是广泛的表型分析将阐明深度和广度 IC/BPS 中并发疾病的研究，并揭示在 IC/BPS 发展中发挥作用的因素 失调。基于这一假设，我们的目标是：1）确定疾病的流行情况 人口统计学上不同的群体（例如焦虑、抑郁、外阴痛）和潜在的环境 影响因素（例如家庭不和、贫困、污染）； 2) 全面、严格地对子集进行表型分析 使用 PROMIS 和 PhenX 工具包对这些患者的合并症进行调查；和 3) 描述健康差异对 IC/BPS 的影响，特别关注健康差异 IC/BPS 影响非裔美国人。由于该项目利用现有群体并进行 通过远程医疗进行表型分析，这是一种具有成本效益的方法，可以更好地表征表型和 阐明 IC/BPS 中维度表型的结构和流行病学。

项目成果

Mendelian Disorders in an Interstitial Cystitis/Bladder Pain Syndrome Cohort.

• DOI: 10.1002/ggn2.202200013
• 发表时间: 2023-03
• 期刊: Advanced genetics (Hoboken, N.J.)
• 作者: Estrella, Elicia;Rockowitz, Shira;Thorne, Marielle;Smith, Pressley;Petit, Jeanette;Zehnder, Veronica;Yu, Richard N;Bauer, Stuart;Berde, Charles;Agrawal, Pankaj B;Beggs, Alan H;Gharavi, Ali G;Kunkel, Louis;Brownstein, Catherine A
• 通讯作者: Brownstein, Catherine A