Missouri Autism Centers of Excellence Collaborative (MACEC): SEED Early Development Study
Missouri Autism Centers of Excellence Collaborative (MACEC): SEED Early Development Study
批准号:
9223435
负责人:
JOHN N. CONSTANTINO
金额:
$71.0万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-07-01 至 2021-06-30
中文摘要
摘要
英文摘要
Abstract
This project is a focused on the continuation of the epidemiological research
capability of the Centers for Autism and Developmental Disabilities Epidemiology
(CADDRE) network with implementation of Phase 3 of the Study to Explore Early
Development. The ongoing objectives of the SEED study are to characterize the autism
behavioral phenotype and associated developmental, medical and behavioral conditions
of autism. and to understand the genetic and environmental risk factors of Autism. The
aims of this application are as follows: 1. Implement a third Phase of the SEED study
preserving the core study design with enhancements to improve recruitment and a
reduction in the data collection protocol in a new Midwestern SEED site. The following
aspects of the core study design will be preserved in Phase 3: a) a case-control study
design with multiple- source ascertainment of an ASD case group, a non- ASD
developmental disability (DD) comparison group and a population-based (POP)
comparison group, b) clinical confirmation of developmental status of all participants
using a standardized assessment protocol, and c) collection of clinical, genetic and
environmental data. Recruitment enhancements will include active follow-up
procedures for invited participants. Data collection will be streamlined, compared to
Phase 2, primarily by eliminating pediatric and neonatal medical record abstraction for
all three participant groups and curtailing data collected for the DD comparison group.
2. Further increase the total SEED pooled sample size to enhance SEED's analytic
potential to investigate rare exposures and ASD subtypes by achieving complete data
collection on 125 ASD children, 125 DD children and 125 POP children within our site.
Reaching these targets at all anticipated Phase 3 sites will increase the total SEED ASD
sample to approximately 2000 children which will enhance the examination of rare
exposures and modest associations potentially relevant to the etiology of ASD.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Missouri Study to Explore Early Development (SEED) Follow-Up
-
批准号:10408656
-
项目类别:
-
资助金额:$31.11万
-
财政年份:2021
-
负责人:JOHN N. CONSTANTINO
-
依托单位:
Missouri Study to Explore Early Development (SEED) Follow-Up
-
批准号:10300870
-
项目类别:
-
资助金额:$30.84万
-
财政年份:2021
-
负责人:JOHN N. CONSTANTINO
-
依托单位:
Missouri Study to Explore Early Development (SEED) Follow-Up
-
批准号:10631976
-
项目类别:
-
资助金额:$32.26万
-
财政年份:2021
-
负责人:JOHN N. CONSTANTINO
-
依托单位:
Harnessing Clinical Genomic Characterization to Accelerate Translational Advances for Patients with IDD
-
批准号:9976668
-
项目类别:
-
资助金额:$132.19万
-
财政年份:2020
-
负责人:JOHN N. CONSTANTINO
-
依托单位:
Harnessing Clinical Genomic Characterization to Accelerate Translational Advances for Patients with IDD
-
批准号:10159337
-
项目类别:
-
资助金额:$125.21万
-
财政年份:2020
-
负责人:JOHN N. CONSTANTINO
-
依托单位:
Washington University Intellectual and Developmental Disabilities Research Center
-
批准号:10224301
-
项目类别:
-
资助金额:$126.0万
-
财政年份:2020
-
负责人:JOHN N. CONSTANTINO
-
依托单位:
Administrative Core
-
批准号:10224302
-
项目类别:
-
资助金额:$14.72万
-
财政年份:2020
-
负责人:JOHN N. CONSTANTINO
-
依托单位:
Administrative Core
-
批准号:10631990
-
项目类别:
-
资助金额:$14.72万
-
财政年份:2020
-
负责人:JOHN N. CONSTANTINO
-
依托单位:
Washington University Intellectual and Developmental Disabilities Research Center
-
批准号:10085124
-
项目类别:
-
资助金额:$124.46万
-
财政年份:2020
-
负责人:JOHN N. CONSTANTINO
-
依托单位:
Administrative Core
-
批准号:10431919
-
项目类别:
-
资助金额:$14.72万
-
财政年份:2020
-
负责人:JOHN N. CONSTANTINO
-
依托单位:
Identification of Newborns at High Risk for the Occurrence of Preventable Child Maltreatment
-
批准号:10475106
-
项目类别:
-
资助金额:$27.67万
-
财政年份:2018
-
负责人:JOHN N. CONSTANTINO
-
依托单位:
Identification of Newborns at High Risk for the Occurrence of Preventable Child Maltreatment
-
批准号:10009472
-
项目类别:
-
资助金额:$25.0万
-
财政年份:2018
-
负责人:JOHN N. CONSTANTINO
-
依托单位:
Identification of Newborns at High Risk for the Occurrence of Preventable Child Maltreatment
-
批准号:10251858
-
项目类别:
-
资助金额:$19.31万
-
财政年份:2018
-
负责人:JOHN N. CONSTANTINO
-
依托单位:
WASHINGTON UNIVERSITY INTELLECTUAL AND DEVELOPMENTAL DISABILITIES RESEARCH CENTER
-
批准号:9318277
-
项目类别:
-
资助金额:$129.19万
-
财政年份:2015
-
负责人:JOHN N. CONSTANTINO
-
依托单位:
Washington University Intellectual and Developmental Disabilities Research Center-Administrative Down Syndrome Supplement
-
批准号:9934527
-
项目类别:
-
资助金额:$56.91万
-
财政年份:2015
-
负责人:JOHN N. CONSTANTINO
-
依托单位:
WASHINGTON UNIVERSITY INTELLECTUAL AND DEVELOPMENTAL DISABILITIES RESEARCH CENTER
-
批准号:9750055
-
项目类别:
-
资助金额:$128.6万
-
财政年份:2015
-
负责人:JOHN N. CONSTANTINO
-
依托单位:
WASHINGTON UNIVERSITY INTELLECTUAL AND DEVELOPMENTAL DISABILITIES RESEARCH CENTER
-
批准号:9146172
-
项目类别:
-
资助金额:$129.59万
-
财政年份:2015
-
负责人:JOHN N. CONSTANTINO
-
依托单位:
NiAD Supplement WashU Start Up
-
批准号:9934358
-
项目类别:
-
资助金额:$23.73万
-
财政年份:2015
-
负责人:JOHN N. CONSTANTINO
-
依托单位:
Autism Genetics, Phase II: Increasing Representation of Human Diversity
-
批准号:9035436
-
项目类别:
-
资助金额:$249.88万
-
财政年份:2013
-
负责人:JOHN N. CONSTANTINO
-
依托单位:
Autism Genetics, Phase II: Increasing Representation of Human Diversity
-
批准号:8386529
-
项目类别:
-
资助金额:$300.59万
-
财政年份:2013
-
负责人:JOHN N. CONSTANTINO
-
依托单位:
海外基金