Training Program in Genomic Medicine

摘要 犹他大学的T32基因组医学培训项目为博士后和博士后学员做准备 成为基因组医学领域全面、协作的领导者。建立在良好的机构培训记录基础上 在基因组学和多学科基因组医学中心独特的培训环境 犹他州健康大学为期两年的基础研究轨道培训计划包括课程作业、指导 研究经验、体验式学习活动、与广泛的基因组社区的广泛互动 医学研究人员和职业发展活动。核心课程涵盖伦理、法律和社会 基因组医学的含义、拨款撰写技巧和应用计算工具的实用技巧 用于疾病基因发现和患者基因组解释。一项有指导的基因组医学研究 在团队科学环境中的经验是培训计划的核心。每名实习生将有一个 多学科指导委员会，从34名医学和博士基因组医学导师库中挑选出来 研究人员。这个高度协作的导师社区拥有许多学科的专业知识， 支持基因组医学，包括人类遗传学、生物信息学、流行病学、统计学、分子生物学 诊断学和药物基因组学。学员将受益于以下几个独特的资源和合作者 基因组医学中心：犹他州基因组计划，一个独立资助的研究项目， 数以千计的犹他州疾病大家系成员正在接受全基因组测序；犹他州 基因发现中心，该大学的计算基因组学引擎和开发 基因组解释的软件工具和算法；ARUP实验室，大学的国家参考 实验室和开发基于基因组学的临床诊断测试的领先者；佩内洛普计划，大学的 罕见和未诊断疾病的诊所，这是未诊断疾病网络的一部分；犹他州新序列 项目，为新生儿重症监护病房带来快速全基因组测序的倡议；以及 亨斯迈癌症研究所，国家癌症研究所指定的综合癌症中心， 广泛的癌症基因组学和精确肿瘤学项目。每一项都将提供沉浸的机会 在基因组医学领域。T32项目的总体目标是：教学员应用尖端技术 生物信息学和计算工具，用于分析基因组数据集；与跨学科高效合作 基因组数据临床应用团队；保护研究并与研究进行有效沟通 参与者；以及推进基因组医学的独立研究事业。在稳定状态下，训练 该项目每年将包括5名博士后和4名博士后实习生。在过去的资助期内，有九家 博士后实习生被任命，推动了他们在基因组医学方面的职业生涯。实习生成绩数据为 跟踪，最佳做法和课程材料将在NHGRI培训网络中传播。

ABSTRACT The T32 Genomic Medicine Training Program at the University of Utah prepares pre- and postdoctoral trainees to be well-rounded, collaborative leaders in genomic medicine. Building on a strong institutional record of training in genomics and the unique training environment of the multidisciplinary Center for Genomic Medicine at University of Utah Health, the two-year basic research track training program consists of coursework, a mentored research experience, experiential learning activities, extensive interactions with a broad community of genomic medicine researchers, and career development activities. Core courses cover the ethical, legal and social implications of genomic medicine, grant writing techniques, and practical skills for applying computational tools for disease-gene discovery and patient genome interpretation. A mentored genomic medicine research experience in a team science environment is the heart of the training program. Each trainee will have a multidisciplinary mentoring committee, drawn from a mentor pool of 34 MD and PhD genomic medicine researchers. This highly collaborative mentor community possesses expertise in the many disciplines that underpin genomic medicine, including human genetics, bioinformatics, epidemiology, statistics, molecular diagnostics, and pharmacogenomics. Trainees will benefit from several unique resources and collaborators in the Center for Genomic Medicine: the Utah Genome Project, an independently funded research project in which thousands of members of large Utah disease pedigrees are undergoing whole-genome sequencing; the Utah Center for Genetic Discovery, the University’s computational genomics engine and hub for development of software tools and algorithms for genome interpretation; ARUP Laboratories, the University’s national reference lab and a leader in developing genomics-based clinical diagnostic tests; the Penelope Program, the University’s clinic for rare and undiagnosed disease, which is part of the Undiagnosed Disease Network; the Utah NeoSeq Project, an initiative to bring rapid whole genome sequencing to the neonatal intensive care unit; and the Huntsman Cancer Institute, a National Cancer Institute Designated Comprehensive Cancer Center and home to extensive cancer genomics and precision oncology projects. Each of these will provide immersion opportunities in genomic medicine. The overall goals of the T32 program are: to teach trainees to apply cutting-edge bioinformatics and computational tools to analyze genomic datasets; to work productively with interdisciplinary teams in the clinical application of genomic data; to protect and communicate effectively with research participants; and to advance an independent research career in genomic medicine. At steady state, the training program will include five predoctoral and four postdoctoral trainees each year. In the past funding period, nine postdoctoral trainees were appointed, advancing their careers in genomic medicine. Trainee outcomes data are tracked, and best practices and course materials will be disseminated across the NHGRI training network.