Childrens flame retardant exposures measured by passive wristbands: Sex specific associations, social adversity, and socio-cognitive development

通过被动腕带测量儿童的阻燃剂暴露：性别特异性关联、社会逆境和社会认知发展

• 批准号: 10645190
• 负责人: Molly L Kile
• 金额: $ 59.39万
• 依托单位: OREGON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10645190
• 关键词: Address; Age; Animal Model; Anxiety Disorders; Attention; Attention deficit hyperactivity disorder; Attenuated; Behavior; Behavior Disorders; Behavioral; Buffers; Characteristics; Chemicals; Child; Child Behavior; Child Development; Child Health; Cognitive; Data; Depressive disorder; Development; Developmental Disabilities; Disease; Emotions; Environmental Risk Factor; Ethnic Origin; Exposure to; Family; Flame Retardants; Goals; Health; Home; Human; Hyperactivity; Individual; Indoor environment; Informal Social Control; Interdisciplinary Study; Intervention; Knowledge; Measurement; Measures; Medical; Mental disorders; Neurocognitive; Nursery Schools; Organophosphates; Pesticides; Phase; Pilot Projects; Policies; Predictive Factor; Prevalence; Problem behavior; Production; Property; Public Health; Research; Risk; Risk Assessment; Risk Factors; School-Age Population; Schools; Short-Term Memory; Silicones; Social Behavior; Social Functioning; Societies; Standardization; System; Testing; Time; Toxicology; United States; aged; behavioral outcome; bullying; cognitive development; cognitive skill; cohort; environmental chemical; executive function; expectation; experience; externalizing behavior; first grade; flexibility; follow-up; health care service; human data; improved; inattention; individual variation; multidisciplinary; neurocognitive disorder; neurodevelopment; neurotoxic; polybrominated diphenyl ether; public health intervention; public health priorities; recruit; resilience; response; severe mental illness; sex; skills; social; social adversity; social deficits; social influence; social skills; social stressor

Project Summary/Abstract Children living in the United States are frequently exposed to polybrominated diphenyl ethers (BDEs) and organophosphate-based compounds (OPFRs) that are used as flame retardants in consumer goods. While the effects of BDE exposure on children’s neuro-cognitive and behavioral development has been studied, there is a lack of data on the developmental effects of OPFR exposure. Yet, toxicological data suggests that OPFRs may be more neurotoxic than BDEs. Animal models also show that social experiences have the potential to attenuate or buffer the effects of neurotoxic chemicals on neuro-cognitive and behavioral outcomes. Therefore, we propose a new interdisciplinary study that will improve our understanding of children’s exposures to flame retardant compounds, as well as, examine the interplay between flame retardants and adverse social experiences on children’s neuro-cognitive, executive functioning, and behavioral development. We propose to recruit 600 children aged 4-8 years as they enter preschool and follow them for 3 years until they graduate from first grade. The development that occurs during this time period is sizeable and corresponds with neural development associated with self-regulation of attention, emotion, and behavior. We will conduct repeated measurements during this follow up period to accomplish the following aims: (1) assess exposure to OPFRs and BDE among a diverse group of children to improve our understanding of factors that contribute to inter- and intra- individual variability, (2) examine the exposure-response relationship between OPFRs and children’s development between ages 4-8 years, and examine the potential for sex to modify these associations, and (3) examine the moderating influences of social stressors on the association between flame retardant exposures and children’s development. These aims all revolve around a central hypothesis that children with higher exposure to OPFRs and/or BDEs and will show lower neuro-cognitive, social, and behavioral skills. Completion of the proposed research is expected to provide new data on the human effects associated with flame retardant chemicals that are commonly found in the indoor environment. This data can be used to inform multi-pronged public health interventions that would ultimately improve children’s health and development.

项目总结/文摘