Childrens flame retardant exposures measured by passive wristbands: Sex specific associations, social adversity, and socio-cognitive development
通过被动腕带测量儿童的阻燃剂暴露:性别特异性关联、社会逆境和社会认知发展
基本信息
- 批准号:10645190
- 负责人:
- 金额:$ 59.39万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-01 至 2025-05-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAgeAnimal ModelAnxiety DisordersAttentionAttention deficit hyperactivity disorderAttenuatedBehaviorBehavior DisordersBehavioralBuffersCharacteristicsChemicalsChildChild BehaviorChild DevelopmentChild HealthCognitiveDataDepressive disorderDevelopmentDevelopmental DisabilitiesDiseaseEmotionsEnvironmental Risk FactorEthnic OriginExposure toFamilyFlame RetardantsGoalsHealthHomeHumanHyperactivityIndividualIndoor environmentInformal Social ControlInterdisciplinary StudyInterventionKnowledgeMeasurementMeasuresMedicalMental disordersNeurocognitiveNursery SchoolsOrganophosphatesPesticidesPhasePilot ProjectsPoliciesPredictive FactorPrevalenceProblem behaviorProductionPropertyPublic HealthResearchRiskRisk AssessmentRisk FactorsSchool-Age PopulationSchoolsShort-Term MemorySiliconesSocial BehaviorSocial FunctioningSocietiesStandardizationSystemTestingTimeToxicologyUnited Statesagedbehavioral outcomebullyingcognitive developmentcognitive skillcohortenvironmental chemicalexecutive functionexpectationexperienceexternalizing behaviorfirst gradeflexibilityfollow-uphealth care servicehuman dataimprovedinattentionindividual variationmultidisciplinaryneurocognitive disorderneurodevelopmentneurotoxicpolybrominated diphenyl etherpublic health interventionpublic health prioritiesrecruitresilienceresponsesevere mental illnesssexskillssocialsocial adversitysocial deficitssocial influencesocial skillssocial stressor
项目摘要
Project Summary/Abstract
Children living in the United States are frequently exposed to polybrominated diphenyl ethers (BDEs) and
organophosphate-based compounds (OPFRs) that are used as flame retardants in consumer goods. While the
effects of BDE exposure on children’s neuro-cognitive and behavioral development has been studied, there is a
lack of data on the developmental effects of OPFR exposure. Yet, toxicological data suggests that OPFRs may be
more neurotoxic than BDEs. Animal models also show that social experiences have the potential to attenuate or
buffer the effects of neurotoxic chemicals on neuro-cognitive and behavioral outcomes. Therefore, we propose
a new interdisciplinary study that will improve our understanding of children’s exposures to flame retardant
compounds, as well as, examine the interplay between flame retardants and adverse social experiences on
children’s neuro-cognitive, executive functioning, and behavioral development. We propose to recruit 600
children aged 4-8 years as they enter preschool and follow them for 3 years until they graduate from first grade.
The development that occurs during this time period is sizeable and corresponds with neural development
associated with self-regulation of attention, emotion, and behavior. We will conduct repeated measurements
during this follow up period to accomplish the following aims: (1) assess exposure to OPFRs and BDE among
a diverse group of children to improve our understanding of factors that contribute to inter- and intra-
individual variability, (2) examine the exposure-response relationship between OPFRs and children’s
development between ages 4-8 years, and examine the potential for sex to modify these associations, and (3)
examine the moderating influences of social stressors on the association between flame retardant exposures
and children’s development. These aims all revolve around a central hypothesis that children with higher
exposure to OPFRs and/or BDEs and will show lower neuro-cognitive, social, and behavioral skills. Completion
of the proposed research is expected to provide new data on the human effects associated with flame retardant
chemicals that are commonly found in the indoor environment. This data can be used to inform multi-pronged
public health interventions that would ultimately improve children’s health and development.
项目总结/摘要
生活在美国的儿童经常接触多溴联苯醚(BDE),
有机磷酸酯基化合物(OPFR)在消费品中用作阻燃剂。而
BDE暴露对儿童神经认知和行为发育的影响进行了研究,
缺乏OPFR暴露对发育影响的数据。然而,毒理学数据表明,OPFR可能是
比溴化二苯醚更具神经毒性。动物模型还表明,社会经验有可能减弱或
缓冲神经毒性化学品对神经认知和行为结果的影响。所以我们提出
一项新的跨学科研究,将提高我们对儿童接触阻燃剂的理解
化合物,以及,研究阻燃剂和不良的社会经验之间的相互作用,
儿童的神经认知、执行功能和行为发展。我们计划招募600人
4-8岁的儿童进入学前班,并跟随他们3年,直到他们从一年级毕业。
在这段时间内发生的发展是相当大的,并与神经发育相对应
与注意力、情绪和行为的自我调节有关。我们将进行重复测量
在此随访期间实现以下目标:(1)评估患者对OPFR和BDE的暴露情况
一个多样化的儿童群体,以提高我们的因素,有助于之间和内部的理解,
个体差异,(2)检查OPFR与儿童
4-8岁之间的发展,并检查性别改变这些关联的潜力,以及(3)
研究社会压力对阻燃剂暴露之间关联的调节作用
和儿童的发展。这些目标都围绕着一个中心假设,即儿童具有更高的
暴露于OPFR和/或溴化二苯醚,并表现出较低的神经认知、社会和行为技能。完成
这项拟议中的研究有望提供与阻燃剂相关的人类影响的新数据。
室内环境中常见的化学物质。这些数据可用于通知多管齐下的
公共卫生干预措施,最终将改善儿童的健康和发展。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Molly L Kile其他文献
Molly L Kile的其他文献
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{{ truncateString('Molly L Kile', 18)}}的其他基金
Advancing Science, Practice, Programming and Policy in Research Translation for Children's Environment Health (Asp3ire)
推进儿童环境健康研究翻译的科学、实践、规划和政策 (Asp3ire)
- 批准号:
10307471 - 财政年份:2021
- 资助金额:
$ 59.39万 - 项目类别:
Advancing Science, Practice, Programming and Policy in Research Translation for Children's Environment Health (Asp3ire)
推进儿童环境健康研究翻译的科学、实践、规划和政策 (Asp3ire)
- 批准号:
10543747 - 财政年份:2021
- 资助金额:
$ 59.39万 - 项目类别:
Advancing Science, Practice, Programming and Policy in Research Translation for Children's Environment Health (Asp3ire)
推进儿童环境健康研究翻译的科学、实践、规划和政策 (Asp3ire)
- 批准号:
10307472 - 财政年份:2021
- 资助金额:
$ 59.39万 - 项目类别:
Advancing Science, Practice, Programming and Policy in Research Translation for Children's Environment Health (Asp3ire)
推进儿童环境健康研究翻译的科学、实践、规划和政策 (Asp3ire)
- 批准号:
10543748 - 财政年份:2021
- 资助金额:
$ 59.39万 - 项目类别:
Childrens flame retardant exposures measured by passive wristbands: Sex specific associations, social adversity, and socio-cognitive development
通过被动腕带测量儿童的阻燃剂暴露:性别特异性关联、社会逆境和社会认知发展
- 批准号:
10004611 - 财政年份:2019
- 资助金额:
$ 59.39万 - 项目类别:
Childrens flame retardant exposures measured by passive wristbands: Sex specific associations, social adversity, and socio-cognitive development
通过被动腕带测量儿童的阻燃剂暴露:性别特异性关联、社会逆境和社会认知发展
- 批准号:
10792412 - 财政年份:2019
- 资助金额:
$ 59.39万 - 项目类别:
Childrens flame retardant exposures measured by passive wristbands: Sex specific associations, social adversity, and socio-cognitive development
通过被动腕带测量儿童的阻燃剂暴露:性别特异性关联、社会逆境和社会认知发展
- 批准号:
10186746 - 财政年份:2019
- 资助金额:
$ 59.39万 - 项目类别:
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