University of Utah Genetics Training Program

犹他大学遗传学培训计划

• 批准号: 10654719
• 负责人: KENT G GOLIC
• 金额: $ 58.88万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10654719
• 关键词: Genetic; Training Programs; Universities; Utah

PROJECT SUMMARY/ABSTRACT The proposed Genetics Training Program (UGTP) at the University of Utah (UofU) will provide in-depth training in Genetics for a diverse group of 12 predoctoral students, arming them with scientific and professional knowledge and skills needed to conduct independent and rigorous research and become leaders within the biomedical research workforce. The U of U has a well-established, successful graduate training effort in genetics research, including a long-running Genetics T32 (45 years). The proposed new UGTP is an intensive two-year program of training in quantitative analysis, rigorous and transparent experimental practices, professional skills, the ethical practice of science, mentorship, and equity/inclusivity. These foundational objectives support the development of future multi-dimensional leaders and mentors in genetics research. The UGTP engages trainees at a formative stage of their career, in their 2nd and 3rd years of graduate school. Benefits of the program extend both before and after the intensive two-year training period. Completion of a pre-requisite first year graduate curriculum covering basic transmission genetics, ethical practices in research, critical thinking, hypothesis development, and understanding of rigor and reproducibility is required for the UGTP. Students who successfully pass a Capstone Exam administered at the end of Year 1, assessing trainee potential for independent research and rigor in scientific analysis and experimental thinking, are eligible for the UGTP. Each year about 12% of the approximately 50 TGE students are selected to become trainees. Trainees convene year-round in a suite of enriching activities. The central feature of the Training Program is a seminar course led by the PDs, limited to trainees, in which the students i) present research, critically evaluate progress, and discuss scientific best practices; undertake continued training in ii) RCR and iii) rigor, transparency, and reproducibility; participate in workshops on iv) professional development, v) mentoring; and vi) recognizing and responding to biased behaviors. Trainees present their research progress annually before the entire UofU Genetics community and select and host visiting genetics speakers throughout the year. Three advanced courses in quantitative and genetics analyses provide a breadth of training in the field of Genetics. The UGTP provides continuous mentorship in research and professional development: trainees develop IDPs with the Program Directors, adopt an extra mentor from the UGTP Steering Committee who provides guidance and communication with the UGTP, and participate in events aimed at career development and building an inclusive community. Following two years of UGTP-supported research with one of 61 UGTP faculty, trainees remain engaged through a novel initiative of near-peer mentorship, a program feature that supports the scientific and cultural development and mentoring skills of our trainees. The UGTP engages the entire UofU genetics community year-round through external speakers, Concepts in Genetics Seminars, and an Annual Retreat featuring trainee talks, plenary speakers, and poster presentations from the UofU genetics community.

项目摘要/摘要 犹他大学(UofU)拟议的遗传学培训计划(UGTP)将提供深入培训 为12名博士前学生提供不同的遗传学课程，为他们提供科学和专业知识 进行独立而严谨的研究并成为行业领导者所需的知识和技能 生物医学研究队伍。伊利诺伊大学在以下领域开展了成熟而成功的研究生培养工作 遗传学研究，包括长期运行的遗传学T32(45年)。拟议的新的联合技术方案是一项密集的 为期两年的定量分析培训方案、严格和透明的实验实践、 专业技能、科学的道德实践、指导和公平/包容性。这些基础设施 目标支持未来遗传学研究的多维领导者和导师的发展。 该计划的受训人员在其职业生涯的形成阶段，在他们的研究生院的第二和第三年。 该计划的好处包括在为期两年的强化训练期之前和之后。填写一份 第一年研究生必修课程包括基础遗传遗传，研究中的伦理实践， 需要批判性思维、假设开发以及对严谨性和重复性的理解 UGTP。成功通过第一年末举行的Capstone考试的学生，评估学员 具有独立研究的潜力以及科学分析和实验思维的严谨，有资格获得 UGTP。每年，在大约50名TGE学生中，约有12%被选为实习生。 学员们一年四季都在一系列丰富的活动中聚会。该培训计划的主要特点是 由PDS主持的研讨会课程，仅限于受训者，在研讨会上，学生i)提出研究，批判性评估 取得进展，并讨论科学最佳做法；继续进行关于RCR和III)严格性的培训， 透明度和可复制性；参加关于四)专业发展、五)指导的讲习班；以及 (六)认识并回应有偏见的行为。受训人员每年都会介绍他们的研究进展 整个UofU遗传学社区，并选择和全年接待来访的遗传学演讲者。三 定量和遗传学分析方面的高级课程提供了遗传学领域的广泛培训。 联合技术方案在研究和专业发展方面提供持续的指导：受训人员发展国内流离失所者 与计划主任一起，从UGTP指导委员会额外聘请一名导师，提供指导 并参与旨在促进职业发展和建立 包容的社区。在与61名UGTP教职员工之一进行了两年UGTP支持的研究后，受训人员 通过一项新的近同行指导计划保持参与，这是一项支持 我们培训学员的科学和文化发展和指导技能。UGTP吸引了整个UofU 通过外部演讲者、遗传学研讨会上的概念和一年一度的 务虚会以学员演讲、全体演讲者和来自Uofu遗传学社区的海报演示为特色。

项目成果

Chromosome Tug of War: Dicentric Chromosomes and the Centromere Strength Hypothesis.

• DOI: 10.3390/cells11223550
• 发表时间: 2022-11-10
• 期刊: CELLS
• 影响因子: 6
• 作者: Hill, Hunter J.;Golic, Kent G.
• 通讯作者: Golic, Kent G.

Histone 4 lysine 5/12 acetylation enables developmental plasticity of Pristionchus mouth form.

组蛋白 4 赖氨酸 5/12 乙酰化使 Pristionchus 口腔形态具有发育可塑性。

• DOI: 10.1038/s41467-023-37734-z
• 发表时间: 2023-04-13
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Werner, Michael S. S.;Loschko, Tobias;King, Thomas;Reich, Shelley;Theska, Tobias;Franz-Wachtel, Mirita;Macek, Boris;Sommer, Ralf J. J.
• 通讯作者: Sommer, Ralf J. J.

An allelic series at the EDNRB2 locus controls diverse piebalding patterns in the domestic pigeon.

• DOI: 10.1371/journal.pgen.1010880
• 发表时间: 2023-10
• 期刊: PLoS genetics
• 影响因子: 4.5

Rapid Evolution of Glycan Recognition Receptors Reveals an Axis of Host-Microbe Arms Races beyond Canonical Protein-Protein Interfaces.

• DOI: 10.1093/gbe/evad119
• 发表时间: 2023-07-03
• 期刊: GENOME BIOLOGY AND EVOLUTION
• 影响因子: 3.3
• 作者: Hilbert, Zoe A.;Haffener, Paige E.;Young, Hannah J.;Schwiesow, Mara J. W.;Leffler, Ellen M.;Elde, Nels C.
• 通讯作者: Elde, Nels C.

FoxA1/2-dependent epigenomic reprogramming drives lineage switching in lung adenocarcinoma.

FoxA1/2 依赖性表观基因组重编程驱动肺腺癌谱系转换。

• DOI: 10.1101/2023.10.30.564775
• 发表时间: 2023
• 期刊: bioRxiv : the preprint server for biology
• 作者: Gillis,Katherine;Orellana,WalterA;Wilson,Emily;Parnell,TimothyJ;Fort,Gabriela;Dadzie,HeadtloveEssel;Zhang,Xiaoyang;Snyder,EricL
• 通讯作者: Snyder,EricL