Sex and Gender Influences on Adoelescent Drug Involvement

性别对青少年吸毒的影响

• 批准号: 7687918
• 负责人: Emmalee S. Bandstra
• 金额: $ 41.94万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7687918
• 关键词: Address; Adolescence; Adolescent; African American; Age; Anxiety; Biological; Biological Markers; Blood specimen; Caregivers; Child; Cocaine; Condition; Data; Decision Making; Development; Disease; Drug Addiction; Drug abuse; Enrollment; Female; Fetal Cocaine Exposure; Funding; Future; Gender; Genetic; Genetic Predisposition to Disease; Genomics; Goals; Health; Health behavior; Hydrocortisone; Impulsivity; Infant; Investigation; Link; Longevity; Measurement; Measures; Mediator of activation protein; Mental Depression; Modeling; Mothers; Outcome; Participant; Patient Self-Report; Perinatal; Pharmaceutical Preparations; Population; Pregnancy; Process; Research; Research Personnel; Risk; Risk Factors; Risk-Taking; Salivary; Secure; Sex Characteristics; Shapes; Stress; Stress and Coping; Substance abuse problem; Testing; Woman; Women' s Health; addiction; drug of abuse; externalizing behavior; improved; in utero; inner city; interdisciplinary approach; male; neuropsychological; postnatal; pre-clinical; prenatal; programs; psychosocial; reproductive; response; sex; social

SCOR Project #3 (Bandstra) relates to the overall Center and the preclinical projects in that it examines an important women's health problem (addiction and related disorders) from an interdisciplinary approach over the lifespan from gestation through adolescence, and ultimately, adulthood. The study seeks to answer important questions about previously understudied hypothesized sex and gender differences in drug involvement through late adolescence as well as the outcomes of female (versus male) offspring exposed to drugs in utero. The project emanates from a well-established research program on perinatal substance abuse. Participants (lowSES, inner-city African American infants and their mothers) were enrolled at delivery (n=476) and have been assessed for developmental, neuropsychological, educational, and social- environmental outcomes through early adolescence (retention 85%). Within a developmental model allowing for multiple determinants of behavior and health, this project seeks to estimate male-female differences in progression through levels of adolescent drug involvement, with examination of hypothesized mediators and correlates including stress/coping, internalizing/externalizing behaviors, impulsivity and risk-taking propensity. The influence of in utero cocaine exposure on observed male-female differences will be assessed. Subjects will be tested at ages 16 and 18 by self-report and biomarkers for drug involvement, caregiver and self-report of psychosocial risk factors, and measures of stress reactivity (with salivary cortisol), risk-taking, and decision-making. Benefiting from data from a related K01, the study will have 4 waves of data on drug involvement from ages 12-18 years for analyses with a sex/gender focus and linkage to earlier data on in utero and longitudinal measurements (e.g., neuropsychological functioning, internalizing and externalizing behaviors). Findings should undergird future planned serial assessments of drug involvement into adulthood, when drug dependence among women during child-bearing years is anticipated to be more prominent, endangering their health and that of their offspring. The ultimate goal is enhanced understanding of the differential effects of drugs of abuse in females and males across development (from prenatal to postnatal exposures during adolescence and adulthood), resulting in improved sex-, gender-, and age-specific preventions and treatments for drug addiction and related conditions.

SCOR项目#3（Bandstra）涉及整个中心和临床前项目，因为它检查了 重要妇女健康问题（吸毒成瘾和有关疾病）， 从妊娠期到青春期，最后到成年期。该研究旨在回答 关于以前未充分研究的假设性和性别差异的重要问题， 通过青少年后期的参与以及女性（与男性）后代暴露于 子宫内的药物该项目源于一个完善的围产期物质研究计划 虐待参与者（低社会经济地位，市中心的非洲裔美国婴儿和他们的母亲）参加了 分娩（n=476），并进行了发育，神经心理，教育和社会- 通过早期青春期的环境成果（保留85%）。在一个发展模型中， 对于行为和健康的多个决定因素，该项目旨在估计男女在以下方面的差异： 通过青少年药物参与水平的进展，检查假设的介质， 相关因素包括压力/应对、内化/外化行为、冲动和冒险 倾向子宫内可卡因暴露对观察到的男女差异的影响将是 评估。受试者将在16岁和18岁时通过自我报告和药物参与的生物标志物进行测试， 照顾者和心理社会风险因素的自我报告，以及应激反应的测量（唾液 皮质醇），冒险和决策。受益于相关K 01的数据，本研究将有4个 关于12-18岁年龄段吸毒情况的数据波，用于以性/性别为重点和联系进行分析 到子宫内和纵向测量的早期数据（例如，神经心理功能，内化 外化行为）。研究结果应支持未来计划的药物系列评估 预期育龄期妇女会出现药物依赖， 更加突出，危及他们和他们后代的健康。最终目标是增强 了解药物滥用对女性和男性在整个发展过程中的不同影响（从 青春期和成年期产前至产后暴露），导致性、性别和 针对不同年龄的吸毒成瘾和相关疾病的预防和治疗。