CHEMICAL SCREENING AND OPTIMIZATION FACILITY - "SCALABLE QUANTITIES OFACTIVE PHARMACEUTICAL INGREDIENTS"
化学筛选和优化设施 - “活性药物成分的可扩展数量”
基本信息
- 批准号:10274475
- 负责人:
- 金额:$ 20.14万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-24 至 2021-09-23
- 项目状态:已结题
- 来源:
- 关键词:AwardBiochemicalBiologicalBiological AssayCharacteristicsChemicalsContraceptive AgentsContraceptive methodsDevelopmentFemale Contraceptive AgentsFormulationGenerationsGoalsMale Contraceptive AgentsMethodsMissionMolecularNational Institute of Child Health and Human DevelopmentOogenesisOutcomeOvulationPharmaceutical ChemistryPharmacologic SubstancePharmacologyPlayProcessProductionRecombinant ProteinsResearchResearch SupportRoleServicesSperm MaturationSpermatogenesisTestingWomanX-Ray Crystallographyassay developmentchemical synthesiscomputational chemistrydrug developmenthigh throughput screeningin silicomeltingmenpreclinical evaluationrecombinant peptidescreening
项目摘要
The Contraception Research Branch (CRB) within the Eunice Kennedy Shriver National Institute of
Child Health and Human Development (NICHD) supports research to develop compounds that can disrupt
oogenesis, spermatogenesis, ovulation, sperm maturation and/or function affording safe and
effective contraceptives for men and/or women. The Chemical Screening and Optimization
Facility (CSOF) fulfills a unique role by identifying, optimizing, and conducting small scale
production of molecular agents that achieve a contraceptive effect. The CSOF provides overall
project management and the capabilities to support these objectives pursuant to
development of new contraceptive methods: these include, but are not limited to, the generation of
recombinant peptides and proteins, assay development, high throughput screening (HTS), x-ray
crystallography, computational chemistry, medicinal chemistry, and pharmacology. Compounds
identified and/or optimized by the CSOF will be prepared under non-Good Manufacturing
Practices (non-GMP) for further preclinical evaluation. The CSOF plays a critical role in the drug
development mission of the CRB.
尤尼斯·肯尼迪·施莱佛国家研究所避孕研究分支(CRB)
儿童健康和人类发展(NICHD)支持研究开发化合物,
卵子发生、精子发生、排卵、精子成熟和/或提供安全和
为男性和/或女性提供有效的避孕药具。 化学筛选与优化
设施(CSOF)通过识别、优化和进行小规模的
产生实现避孕效果的分子药剂。 CSOF提供全面的
项目 管理 和 的 能力 到 支持 这些 目标 根据 到
开发新的避孕方法:这些方法包括但不限于:
重组肽和蛋白质,检测开发,高通量筛选(HTS),x射线
晶体学、计算化学、药物化学和药理学。 化合物
由CSOF确定和/或优化的产品将在非良好生产条件下制备
用于进一步临床前评价的规范(非GMP)。CSOF在药物中起着关键作用
CRB的发展使命。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('LEYI GONG', 18)}}的其他基金
CHEMICAL SCREENING AND OPTIMIZATION FACILITY - MANAGEMENT, ADMINISTRATION AND DATABASE CORE FUNCTION ACTIVITIES
化学筛选和优化设施 - 管理、行政和数据库核心功能活动
- 批准号:
10942871 - 财政年份:2023
- 资助金额:
$ 20.14万 - 项目类别:
CHEMICAL SCREENING AND OPTIMIZATION FACILITY - PROTEIN EXPRESSION AND/OR X-RAY CRYSTALLOGRAPHY
化学筛选和优化设施 - 蛋白质表达和/或 X 射线晶体学
- 批准号:
10942884 - 财政年份:2023
- 资助金额:
$ 20.14万 - 项目类别:
CHEMICAL SCREENING AND OPTIMIZATION FACILITY - SCALABLE QUANTITIES
化学筛选和优化设施 - 可扩展数量
- 批准号:
10942882 - 财政年份:2023
- 资助金额:
$ 20.14万 - 项目类别:
Task B28: Efficacy Studies for Therapeutics Development
任务 B28:治疗药物开发的功效研究
- 批准号:
10703289 - 财政年份:2022
- 资助金额:
$ 20.14万 - 项目类别:
CHEMICAL SCREENING AND OPTIMIZATION FACILITY (CSOF) – DRUG AND SUBSTANCE
化学筛选和优化设施 (CSOF) – 药物和物质
- 批准号:
10710754 - 财政年份:2022
- 资助金额:
$ 20.14万 - 项目类别:
CHEMICAL SCREENING AND OPTIMIZATION FACILITY (CSOF) - CHEMICAL OPTIMIZATION APPROACHES
化学筛选和优化设施 (CSOF) - 化学优化方法
- 批准号:
10710755 - 财政年份:2022
- 资助金额:
$ 20.14万 - 项目类别:
CHEMICAL SCREENING AND OPTIMIZATION FACILITY- HIGH THROUGHPUT SCREENING
化学筛选和优化设施 - 高通量筛选
- 批准号:
10421851 - 财政年份:2021
- 资助金额:
$ 20.14万 - 项目类别:
CHEMICAL SCREENING AND OPTIMIZATION FACILITY - "STRUCTURE ACTIVITY RELATIONSHIPS"
化学筛选和优化设施 - “结构活性关系”
- 批准号:
10274476 - 财政年份:2020
- 资助金额:
$ 20.14万 - 项目类别:
CHEMICAL SCREENING AND OPTIMIZATION FACILITY - PROTEIN GENERATION
化学筛选和优化设施 - 蛋白质生成
- 批准号:
10022550 - 财政年份:2019
- 资助金额:
$ 20.14万 - 项目类别:
CHEMICAL SCREENING AND OPTIMIZATION FACILITY - STRUCTURE ACTIVITY RELATIONSHIPS
化学筛选和优化设施 - 结构活性关系
- 批准号:
10022551 - 财政年份:2019
- 资助金额:
$ 20.14万 - 项目类别:
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