CHEMICAL SCREENING AND OPTIMIZATION FACILITY - PROTEIN GENERATION

化学筛选和优化设施 - 蛋白质生成

• 批准号: 10022550
• 负责人: LEYI GONG
• 金额: $ 17.11万
• 依托单位: SRI INTERNATIONAL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-20 至 2024-09-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10022550
• 关键词: Agonist; Chemicals; Contraceptive Agents; Contraceptive methods; Contractor; Contracts; Development; Discipline; Fertility; Generations; Goals; In Vitro; Lead; Methods; Mission; National Institute of Child Health and Human Development; Peptides; Pharmaceutical Chemistry; Pharmacology; Pregnancy; Production; Proteins; Recombinant Proteins; Regulation; Research; Role; Series; United States; Woman; X-Ray Crystallography; assay development; computational chemistry; drug development; drug discovery; high throughput screening; in vivo evaluation; interest; men; novel; protein purification; reproductive; screening; small molecule

Nearly half of all pregnancies in the United States are unintended. There is a critical need for fertility regulation methods that fit the needs of women and men throughout their reproductive lives. The objective of this contract is to support the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) in its mission to develop novel contraceptive methods by providing a Chemical Screening and Optimization Facility (CSOF) to identify safe and effective contraceptive agents for development. The CSOF also has an important role in the production of optimized compounds for early stage in vitro and in vivo testing.

在美国，近一半的怀孕是意外的。目前迫切需要适合妇女和男子整个生殖生命期需要的生育调节方法。该合同的目的是支持尤尼斯·肯尼迪·施莱佛国家儿童健康和人类发展研究所（NICHD）的使命，通过提供化学筛选和优化设施（CSOF）来确定安全有效的避孕剂，以促进发展，从而开发新的避孕方法。CSOF在生产用于早期体外和体内测试的优化化合物中也具有重要作用。