CHEMICAL SCREENING AND OPTIMIZATION FACILITY - SCALABLE QUANTITIES

化学筛选和优化设施 - 可扩展数量

• 批准号: 10942882
• 负责人: LEYI GONG
• 金额: $ 77.32万
• 依托单位: SRI INTERNATIONAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-29 至 2026-09-27
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10942882
• 关键词: Adenomyosis; Bacterial Infections; Carbon; Chemicals; Contraceptive Agents; Contraceptive methods; Contracts; Down Syndrome; Dysmenorrhea; Fetal Growth Retardation; Fibroid Tumor; Generations; Gestational Diabetes; Gynecologic; Health; High Pressure Liquid Chromatography; Infertility; Inflammation; Lactation; Methods; Muscular Dystrophies; National Institute of Child Health and Human Development; Natural Products; Necrotizing Enterocolitis; Nuclear Magnetic Resonance; Pelvic Pain; Perinatal; Pituitary-dependent Cushing' s disease; Placenta; Polycystic Ovary Syndrome; Polymers; Pre-Eclampsia; Premature Birth; Production; Protons; Reproductive Health; Research; Rett Syndrome; Role; Sampling; Sepsis; United States National Institutes of Health; Virus Diseases; Vulvodynia; Work; autism spectrum disorder; endometriosis; improved; infrared spectroscopy; liquid chromatography mass spectrometry; mastitis; melting; microbiome; screening; small molecule

The Chemical Screening and Optimization Facility (CSOF) fulfills a unique role by identifying, optimizing and conducting production identified small molecules for contraceptive and reproductive health related (e.g., infertility, polycystic ovarian syndrome, fibroids, endometriosis, dysmenorrhea, adenomyosis, gynecologic and/or pelvic pain, and vulvodynia, premature birth, placenta health, improving lactation quality and quantity, preeclampsia, perinatal microbiome, gestational diabetes, inflammation, bacterial infections, viral infections, necrotizing enterocolitis, bronchopulmonary dyplasia, pre-term birth, fetal growth restriction, mastitis, Cushing's disease, Down Syndrome, Ricketts, Muscular Dystrophy, Rett syndrome, sepsis, or Autism) research. One approach is to conduct scalable quantity projects of identified small molecule(s) (e.g., natural product) and/or large molecule (e.g., polymer) that afford a contraceptive effect against a validated target or as a treatment for an identified reproductive health related indication. The research contained within this task order will encompass generation and purification of small or large molecules where purity of the final product shall be verified using methods including, but not limited to, Proton-Nuclear Magnetic Resonance (1H-NMR), Carbon-13-Nuclear Magnetic Resonance (C-NMR), Liquid Chromatography–Mass Spectrometry (LC-MS), High-Performance Liquid Chromatography (HPLC), Infrared (IR) Spectroscopy, melting point.

化学筛选和优化设施（CSOF）通过识别、优化和生产与避孕和生殖健康相关的确定小分子(例如，不孕症、多囊卵巢综合征、肌瘤、子宫内膜异位症、痛经、子宫腺肌症、妇科和/或盆腔疼痛、外阴痛、早产、胎盘健康、改善哺乳质量和数量、先兆子痫、围产期微生物群、妊娠糖尿病、炎症、细菌感染、病毒感染、坏死性小肠结肠炎、支气管肺发育不良、早产、胎儿生长受限、乳腺炎、库欣氏病、唐氏综合征、佝偻病、肌肉萎缩症、Rett综合征、败血症或自闭症)研究。一种方法是开展可扩展数量的已确定的小分子（例如，天然产物）和/或大分子（例如，聚合物）项目，这些项目对已确认的目标具有避孕作用，或作为已确定的生殖健康相关适应症的治疗方法。本任务订单中包含的研究将包括小分子或大分子的生成和纯化，其中最终产品的纯度将使用包括但不限于质子核磁共振（1H-NMR），碳-13核磁共振（C-NMR），液相色谱-质谱（LC-MS），高效液相色谱（HPLC），红外（IR）光谱，熔点等方法进行验证。