Biospecimen Procurement & Utilization Core

生物样本采购

• 批准号: 10044537
• 负责人: Richard Bernard Hayes
• 金额: $ 32.28万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-17 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10044537
• 关键词: African American; Asians; Blood; Cell Separation; Clinical; Clinical Data; Collaborations; Collection; Communities; Data; Databases; Development; Disease; Ensure; Epidemiology; Family; Feces; Food; Fostering; Goals; Hispanics; Human; Human Resources; Immunohistochemistry; Immunophenotyping; Infrastructure; Institution; International; Investigation; Latino; Link; Maintenance; Malignant Neoplasms; Microdissection; Minority; Mission; Nucleic Acids; Nucleic acid sequencing; Oral; Participant; Pathologic; Pathology; Patients; Population; Positioning Attribute; Preparation; Process; Program Research Project Grants; Quality Control; Recording of previous events; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resource Sharing; Resources; Sampling; Services; Specimen; Standardization; Structure; T-Lymphocyte; Tissues; Translational Research; Work; biobank; cancer health disparity; cancer site; cohort; design; ethnic minority population; health equity; improved; innovation; melanoma; member; microbiome; microbiota; novel; operation; professor; programs; prospective; racial and ethnic; stool sample; translational research program

PROJECT SUMMARY Core B (Biospecimen Procurement & Utilization Core) will serve as the biospecimen and pathology shared resource core for the NYU Cancer Health Disparities (CHD) SPORE. The goal of Core B is to foster translational research on CHD, by providing all NYU CHD SPORE investigators—including research project co-leaders and Developmental Research Program (DRP) awardees—with 1) access to high-quality biospecimens, linked to prospectively collected clinical and pathological data; and 2) innovative services that promote the aims of these projects. To meet the specific needs of the NYU CHD SPORE, Core B places a particular emphasis on collection of biospecimens from racial/ethnic minority populations, including African Americans, Asians, and Hispanics/Latinos. Core B is designed to coordinate the procurement and processing of human biospecimens, including tissue, blood, oral wash samples, and stool, for the NYU CHD SPORE. Core B will improve efficiencies of operations of the NYU CHD SPORE by also serving as the central NYU CHD SPORE Biorepository Database for the development, annotation, and maintenance of this human cancer biospecimen resource, including linkage of specimens with pre-analytical parameters and pathological, clinical, and family history data. Furthermore, in preparation of biospecimens for downstream project-specific analyses, Core B will provide standardized services for the NYU CHD SPORE, including microdissection, immunohistochemistry, extraction of nucleic acids for sequencing, and the disaggregation of tissues into cellular components, for immunophenotyping. Through a governance committee, Core B will also provide oversight of SPORE biospecimen use. Building on the infrastructure of the NYU Food and Microbiome Longitudinal Investigation (FAMiLI) multi-ethnic community cohort and extensive support from NYULH, Core B will provide resources and stimulate collaborations within the NYU CHD SPORE community as well as with outside collaborators, including other currently active SPOREs. Given the considerable translational research infrastructure and resources at NYU, Core B personnel will also work closely with the Administrative Core to ensure the most efficient use of institutional resources without duplicating efforts. Overall, Core B will provide high quality, annotated biospecimens to all SPORE studies to support the NYU CHD SPORE’s mission to increase orodigestive tract cancer health equity by identifying, understanding, and controlling the microbiota related to these diseases.

项目概要 核心B（生物样本采购和利用核心）将作为生物样本和病理共享 纽约大学癌症健康差异 (CHD) SPORE 的资源核心。核心 B 的目标是促进转化 通过提供所有纽约大学 CHD SPORE 研究人员（包括研究项目联合领导者和 发展研究计划 (DRP) 获奖者 - 1) 获得高质量的生物样本，与 前瞻性收集的临床和病理数据； 2) 促进这些目标的创新服务 项目。为了满足 NYU CHD SPORE 的特定需求，Core B 特别强调收集 来自种族/族裔少数群体的生物样本，包括非裔美国人、亚洲人和 西班牙裔/拉丁裔。 Core B 旨在协调人类生物样本的采购和处理，包括组织、 纽约大学 CHD SPORE 的血液、口腔洗液样本和粪便。核心B将提高运营效率 NYU CHD SPORE 还充当纽约大学 CHD SPORE 生物储存库数据库 该人类癌症生物样本资源的开发、注释和维护，包括 具有分析前参数以及病理、临床和家族史数据的样本。此外，在 为下游项目特定分析准备生物样本，核心 B 将提供标准化服务 纽约大学 CHD SPORE，包括显微解剖、免疫组织化学、核酸提取 测序，以及将组织分解成细胞成分，以进行免疫表型分析。通过一个 治理委员会核心 B 还将对 SPORE 生物样本的使用进行监督。建立在 纽约大学食品和微生物组纵向调查 (FAMiLI) 多种族社区的基础设施 纽约大学医院 (NYULH) 的队列和广泛支持，核心 B 将提供资源并促进内部合作 纽约大学 CHD SPORE 社区以及外部合作者，包括其他当前活跃的 SPORE。 鉴于纽约大学拥有大量的转化研究基础设施和资源，核心 B 人员也将 与行政核心密切合作，确保最有效地利用机构资源，而无需 重复的努力。总体而言，Core B 将为所有 SPORE 研究提供高质量的带注释的生物样本 支持纽约大学 CHD SPORE 的使命，通过识别、 了解并控制与这些疾病相关的微生物群。