Biospecimen Procurement & Utilization Core

项目总结 核心B(生物质学采购与利用核心)将作为生物质学和病理学共享 纽约大学癌症健康差异(CHD)孢子资源核心。核心B的目标是促进翻译 CHD研究，通过提供纽约大学CHD孢子研究人员-包括研究项目联合负责人和 发展研究计划(DRP)获奖者-1)获得高质量的生物样品，与 前瞻性地收集临床和病理数据；以及2)促进这些目标的创新服务 项目。为了满足纽约大学CHD孢子的具体需求，核心B特别强调收集 来自种族/少数民族人口的生物群落，包括非裔美国人、亚洲人和 拉美裔/拉丁裔。 核心B旨在协调人类生物标本的采购和加工，包括组织， 血液，口腔清洗样本，和粪便，用于纽约大学CHD孢子。核心B将提高以下项目的运营效率 纽约大学CHD孢子还作为纽约大学CHD孢子生物信息库的中央数据库 这一人类癌症生物谱系资源的开发、注释和维护，包括 具有分析前参数以及病理、临床和家族史数据的样本。此外，在 为下游项目具体分析准备生物样品，核心B将提供标准化服务 对于纽约大学CHD孢子，包括显微解剖，免疫组织化学，核酸提取 测序，并将组织解聚成细胞成分，用于免疫表型。通过一个 治理委员会，核心B还将提供对孢子生物喷雾剂使用的监督。建立在 纽约大学食品和微生物纵向调查(REMERI)多民族社区的基础设施 来自NYULH的队列和广泛支持，Core B将提供资源并促进 纽约大学CHD孢子社区以及外部合作者，包括其他目前活跃的孢子。 鉴于纽约大学有大量的翻译研究基础设施和资源，Core B的工作人员也将 与行政核心密切合作，确保最有效地利用机构资源 重复的努力。总体而言，核心B将向所有孢子研究提供高质量的注释生物标本，以 支持纽约大学CHD孢子的使命，通过确定， 了解和控制与这些疾病相关的微生物区系。

PROJECT SUMMARY Core B (Biospecimen Procurement & Utilization Core) will serve as the biospecimen and pathology shared resource core for the NYU Cancer Health Disparities (CHD) SPORE. The goal of Core B is to foster translational research on CHD, by providing all NYU CHD SPORE investigators—including research project co-leaders and Developmental Research Program (DRP) awardees—with 1) access to high-quality biospecimens, linked to prospectively collected clinical and pathological data; and 2) innovative services that promote the aims of these projects. To meet the specific needs of the NYU CHD SPORE, Core B places a particular emphasis on collection of biospecimens from racial/ethnic minority populations, including African Americans, Asians, and Hispanics/Latinos. Core B is designed to coordinate the procurement and processing of human biospecimens, including tissue, blood, oral wash samples, and stool, for the NYU CHD SPORE. Core B will improve efficiencies of operations of the NYU CHD SPORE by also serving as the central NYU CHD SPORE Biorepository Database for the development, annotation, and maintenance of this human cancer biospecimen resource, including linkage of specimens with pre-analytical parameters and pathological, clinical, and family history data. Furthermore, in preparation of biospecimens for downstream project-specific analyses, Core B will provide standardized services for the NYU CHD SPORE, including microdissection, immunohistochemistry, extraction of nucleic acids for sequencing, and the disaggregation of tissues into cellular components, for immunophenotyping. Through a governance committee, Core B will also provide oversight of SPORE biospecimen use. Building on the infrastructure of the NYU Food and Microbiome Longitudinal Investigation (FAMiLI) multi-ethnic community cohort and extensive support from NYULH, Core B will provide resources and stimulate collaborations within the NYU CHD SPORE community as well as with outside collaborators, including other currently active SPOREs. Given the considerable translational research infrastructure and resources at NYU, Core B personnel will also work closely with the Administrative Core to ensure the most efficient use of institutional resources without duplicating efforts. Overall, Core B will provide high quality, annotated biospecimens to all SPORE studies to support the NYU CHD SPORE’s mission to increase orodigestive tract cancer health equity by identifying, understanding, and controlling the microbiota related to these diseases.