Biospecimen Procurement & Utilization Core

生物样本采购

• 批准号: 10265457
• 负责人: Richard Bernard Hayes
• 金额: $ 32.87万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-17 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10265457
• 关键词: African American; Asians; Biological Specimen database; Blood; Cell Separation; Clinical; Clinical Data; Collaborations; Collection; Communities; Data; Development; Disease; Ensure; Epidemiology; Family; Feces; Food; Fostering; Goals; Hispanics; Human; Human Resources; Immunohistochemistry; Immunophenotyping; Infrastructure; Institution; International; Investigation; Latino; Link; Maintenance; Malignant Neoplasms; Microdissection; Minority Groups; Mission; Nucleic Acids; Nucleic acid sequencing; Oral; Participant; Pathologic; Pathology; Patients; Positioning Attribute; Preparation; Process; Program Research Project Grants; Quality Control; Recording of previous events; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resource Sharing; Resources; Sampling; Services; Specimen; Standardization; Structure; T-Lymphocyte; Tissues; Translational Research; Work; biobank; cancer health disparity; cancer site; cohort; design; ethnic minority population; health equity; improved; innovation; melanoma; member; microbiome; microbiota; multi-ethnic; multi-racial; novel; operation; professor; programs; prospective; racial and ethnic; stool sample; translational research program

PROJECT SUMMARY Core B (Biospecimen Procurement & Utilization Core) will serve as the biospecimen and pathology shared resource core for the NYU Cancer Health Disparities (CHD) SPORE. The goal of Core B is to foster translational research on CHD, by providing all NYU CHD SPORE investigators—including research project co-leaders and Developmental Research Program (DRP) awardees—with 1) access to high-quality biospecimens, linked to prospectively collected clinical and pathological data; and 2) innovative services that promote the aims of these projects. To meet the specific needs of the NYU CHD SPORE, Core B places a particular emphasis on collection of biospecimens from racial/ethnic minority populations, including African Americans, Asians, and Hispanics/Latinos. Core B is designed to coordinate the procurement and processing of human biospecimens, including tissue, blood, oral wash samples, and stool, for the NYU CHD SPORE. Core B will improve efficiencies of operations of the NYU CHD SPORE by also serving as the central NYU CHD SPORE Biorepository Database for the development, annotation, and maintenance of this human cancer biospecimen resource, including linkage of specimens with pre-analytical parameters and pathological, clinical, and family history data. Furthermore, in preparation of biospecimens for downstream project-specific analyses, Core B will provide standardized services for the NYU CHD SPORE, including microdissection, immunohistochemistry, extraction of nucleic acids for sequencing, and the disaggregation of tissues into cellular components, for immunophenotyping. Through a governance committee, Core B will also provide oversight of SPORE biospecimen use. Building on the infrastructure of the NYU Food and Microbiome Longitudinal Investigation (FAMiLI) multi-ethnic community cohort and extensive support from NYULH, Core B will provide resources and stimulate collaborations within the NYU CHD SPORE community as well as with outside collaborators, including other currently active SPOREs. Given the considerable translational research infrastructure and resources at NYU, Core B personnel will also work closely with the Administrative Core to ensure the most efficient use of institutional resources without duplicating efforts. Overall, Core B will provide high quality, annotated biospecimens to all SPORE studies to support the NYU CHD SPORE’s mission to increase orodigestive tract cancer health equity by identifying, understanding, and controlling the microbiota related to these diseases.

项目摘要 核心B（生物标本采购和利用核心）将作为生物标本和病理学共享 NYU Cancer Health Disparities（CHD）SPORE的核心资源。核心B的目标是促进翻译 研究冠心病，通过提供所有纽约大学冠心病孢子制造商-包括研究项目共同领导人和 发展研究计划（DRP）奖-1）获得高质量的生物标本，与 前瞻性收集的临床和病理数据; 2）创新服务，促进这些目标 项目为了满足NYU CHD SPORE的特定需求，Core B特别强调收集 来自种族/少数民族人群的生物标本，包括非裔美国人、亚洲人和 西班牙裔/拉丁裔。 核心B旨在协调人体生物标本的采购和处理，包括组织， 血液、口腔清洗样本和粪便，用于NYU CHD孢子。核心B将提高 NYU CHD SPORE还作为中央NYU CHD SPORE生物储存库数据库， 开发、注释和维护这一人类癌症生物标本资源，包括 具有分析前参数和病理学、临床和家族史数据的标本。更以 为下游项目特定分析准备生物标本，核心B将提供标准化服务 为纽约大学冠心病孢子，包括显微解剖，免疫组织化学，核酸提取， 测序和将组织分解成细胞组分，用于免疫表型分析。通过 管理委员会，核心B还将监督SPORE生物标本的使用。基础上 纽约大学食品和微生物组纵向调查（FAMiLI）多民族社区的基础设施 核心B将提供资源，并促进 纽约大学CHD SPORE社区以及外部合作者，包括其他目前活跃的SPORE。 鉴于纽约大学拥有大量的转化研究基础设施和资源，核心B人员还将 与行政核心密切合作，确保最有效地利用机构资源， 重复的努力。总体而言，核心B将为所有SPORE研究提供高质量的注释生物标本， 支持纽约大学CHD SPORE的使命，通过识别， 了解和控制与这些疾病有关的微生物群。