Neurobiological Mechanisms Underlying the Symptoms and Course of Schizophrenia

描述（由申请人提供）：这是从精神病学的UCSF部门的机构培训补助金（T32）的应用程序。我们建议对最近的医学博士、博士和医学博士/博士进行用于研究精神分裂症症状及其神经发育和神经退行性过程的神经生物学机制的方法的培训。以精神分裂症为导向的方法避免了与精神分裂症作为一种诊断的异质性相关的问题;神经科学方法使我们更接近负责症状的基质和机制;病程方法使我们能够解决可能的预防，干预和治疗。这些方法反映了拟议的T32教师的研究兴趣和专业知识。 研究：我们充分利用精神病学系的成员，他们使用神经科学方法，与人类和非人类物种一起，了解精神分裂症的许多表现形式。每个学员将在第一年做一个导师发起的项目，并在第二个自我发起的项目，都导致在地方，国家和国际生物精神病学会议的论文，海报和平台会谈。 学历：学员将参加我们为期一年的每周T32综合研讨会系列和我们为期一年的精神病学神经科学课程;参加由学员和导师确定的正式UCSF课程;并参加关于负责任的研究行为的年度课程。学员将与他们的研究导师每周和职业导师，每月见面。 培训内容：学员将与研究和职业导师双辅导，以指导他们正式和非正式，学习神经生物学方法，产生一个数据体，在全国会议上展示数据，撰写和出版论文，准备赠款提案，并参加当地和国家研讨会上推出和保持成功的职业生涯在生物精神病学。 T32学院包括基础神经科学家和精神病学家，从事遗传学，脑成像，电生理学和神经可塑性方面的工作。T32学院的每位成员将担任不同学员的研究和职业导师。T32将由朱迪思福特博士指导，并由执行委员会管理，执行委员会由福特博士、马萨隆博士、维诺格拉多夫博士、雷乌斯博士和巴龙德斯博士组成。除了第一年只有3名受训人员外，每次将有5名受训人员。 公共卫生相关性：这项机构培训补助金将在5年的课程中培训新一代的14名神经科学家，以研究精神分裂症的神经病理生理学。培养这些合格的博士后学者是了解这种影响世界1%人口的毁灭性疾病的重要一步，并确保新一代的精神健康学术研究临床医生将可用于改善精神分裂症患者的生活。

DESCRIPTION (provided by applicant): This is an application from the UCSF Department of Psychiatry for an Institutional Training Grant (T32). We propose to train recent MDs, PhDs, and MD/PhDs in methods used to study the neurobiological mechanisms underlying the symptoms of schizophrenia and its neuro-developmental and neuro- degenerative course. The symptom-oriented approach avoids issues associated with the heterogeneity of schizophrenia as a diagnosis; the neuroscience approach allows us to get closer to the substrates and mechanisms responsible for the symptom; the illness-course approach allows us to address possible prevention, intervention, and treatment. These approaches reflect the research interests and expertise of the proposed T32 faculty. Research: We have taken full advantage of the members of the Psychiatry Faculty who use neuroscience methods, with both human and non-human species, to understand schizophrenia, in its many manifestations. Each trainee will do a mentor-initiated project in the first year and a self-initiated project in the second, both resulting in papers, posters and platform talks at local, national, and international meetings on biological psychiatry. Education: Trainees will participate in our year-long integrative weekly T32 Seminar Series and our year- long Neuroscience in Psychiatry course; take formal UCSF courses identified by the trainee and mentor; and take yearly courses on the Responsible Conduct of Research. Trainees will meet with their Research Mentors weekly and Career Mentors, monthly. Training: Trainees will be dual-mentored with Research and Career Mentors to guide them both formally and informally, learning neurobiological methods, producing a body of data, presenting data at national meetings, writing and publishing papers, preparing grant proposals, and attending local and national workshops on launching and maintaining successful careers in biological psychiatry. The T32 Faculty includes basic neuroscientists and psychiatrists, working in genetics, brain imaging, electrophysiology, and neuroplasticity. Each member of the T32 Faculty will serve as Research and Career Mentors to different trainees. The T32 will be directed by Dr. Judith Ford and administered by the Executive Committee, comprised of Drs. Ford, Mathalon, Vinogradov, Reus and Barondes. Except during the first year, when there will be only three trainees, there will be 5 trainees at a time. PUBLIC HEALTH RELEVANCE: This institutional training grant, over its 5 year course, will train a new generation of 14 neuroscientists to investigate the neuropathophysiology of schizophrenia. Training these qualified postdoctoral scholars is an important step towards understanding this devastating illness that affects 1% of the world's population and assures a new generation of mental health academic research-clinicians will be available to improve the lives of persons with schizophrenia.