Neurobiological Mechanisms Underlying the Symptoms and Course of Schizophrenia

描述（由申请人提供）：这是一份来自加州大学旧金山分校精神病学部门的机构培训补助金申请（T32）。我们建议对新近的医学博士、博士和医学博士/博士进行方法培训，以研究精神分裂症症状及其神经发育和神经退行性过程的神经生物学机制。以症状为导向的方法避免了与精神分裂症诊断异质性相关的问题；神经科学方法让我们更接近导致症状的基础和机制；病程方法使我们能够解决可能的预防、干预和治疗问题。这些方法反映了拟议的T32教师的研究兴趣和专业知识。研究：我们充分利用了精神病学学院的成员，他们使用神经科学方法，对人类和非人类物种进行研究，以了解精神分裂症的许多表现形式。每个学员将在第一年做一个导师发起的项目，第二年做一个自我发起的项目，这两个项目都会在当地、国家和国际生物精神病学会议上发表论文、海报和平台演讲。培训：学员将参加为期一年的每周综合T32系列研讨会和为期一年的精神病学神经科学课程；参加由学员和导师指定的正式UCSF课程；并每年参加负责任的研究行为课程。学员将每周与他们的研究导师会面，每月与职业导师会面。培训：受训者将受到研究和职业导师的双重指导，以正式和非正式的方式指导他们学习神经生物学方法，生成数据体，在国家会议上展示数据，撰写和发表论文，准备拨款提案，并参加有关启动和维持生物精神病学成功职业的地方和国家讲习班。T32学院包括基础神经科学家和精神科医生，从事遗传学、脑成像、电生理学和神经可塑性方面的工作。T32学院的每位成员都将担任不同学员的研究和职业导师。T32将由Judith Ford博士指导，并由执行委员会管理。福特，马瑟伦，维诺格拉多夫，罗伊斯和巴伦德斯。除了第一年只有3名学员外，每次都会有5名学员。

DESCRIPTION (provided by applicant): This is an application from the UCSF Department of Psychiatry for an Institutional Training Grant (T32). We propose to train recent MDs, PhDs, and MD/PhDs in methods used to study the neurobiological mechanisms underlying the symptoms of schizophrenia and its neuro-developmental and neuro- degenerative course. The symptom-oriented approach avoids issues associated with the heterogeneity of schizophrenia as a diagnosis; the neuroscience approach allows us to get closer to the substrates and mechanisms responsible for the symptom; the illness-course approach allows us to address possible prevention, intervention, and treatment. These approaches reflect the research interests and expertise of the proposed T32 faculty. Research: We have taken full advantage of the members of the Psychiatry Faculty who use neuroscience methods, with both human and non-human species, to understand schizophrenia, in its many manifestations. Each trainee will do a mentor-initiated project in the first year and a self-initiated project in the second, both resulting in papers, posters and platform talks at local, national, and international meetings on biological psychiatry. Education: Trainees will participate in our year-long integrative weekly T32 Seminar Series and our year- long Neuroscience in Psychiatry course; take formal UCSF courses identified by the trainee and mentor; and take yearly courses on the Responsible Conduct of Research. Trainees will meet with their Research Mentors weekly and Career Mentors, monthly. Training: Trainees will be dual-mentored with Research and Career Mentors to guide them both formally and informally, learning neurobiological methods, producing a body of data, presenting data at national meetings, writing and publishing papers, preparing grant proposals, and attending local and national workshops on launching and maintaining successful careers in biological psychiatry. The T32 Faculty includes basic neuroscientists and psychiatrists, working in genetics, brain imaging, electrophysiology, and neuroplasticity. Each member of the T32 Faculty will serve as Research and Career Mentors to different trainees. The T32 will be directed by Dr. Judith Ford and administered by the Executive Committee, comprised of Drs. Ford, Mathalon, Vinogradov, Reus and Barondes. Except during the first year, when there will be only three trainees, there will be 5 trainees at a time.