Role of Executive Control in Adolescent Substance Use and Co-occuring Problems

执行控制在青少年药物使用和同时发生的问题中的作用

• 批准号: 10239267
• 负责人: W Alex Mason
• 金额: $ 55.17万
• 依托单位: UNIVERSITY OF TENNESSEE HEALTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10239267
• 关键词: Accidents; Adolescence; Adolescent; Age; Alcohol consumption; Behavior; Cause of Death; Child; Childhood; Data; Development; Developmental Process; Dimensions; Family; Gender; Goals; Growth Factor; Health; Homicide; Individual; Individual Differences; Intervention; Link; Longitudinal Studies; Marijuana; Measurement; Mediating; Mediator of activation protein; Methods; Morbidity - disease rate; National Institute of Drug Abuse; Nursery Schools; Outcome; Parents; Participant; Performance; Plant Roots; Prevention; Problem Solving; Problem behavior; Public Health; Research; Risk; Risk Factors; Role; Sampling; Schools; Social Development; Specific qualifier value; Strategic Planning; Suicide; Teenagers; Testing; Time; United States National Institutes of Health; Youth; adolescent substance use; adverse outcome; base; cigarette smoke; cognitive ability; cognitive process; critical developmental period; design; directed attention; early onset; elementary school; executive function; innovation; insight; intervention refinement; longitudinal design; marijuana use; model development; modifiable risk; mortality; neurodevelopment; peer; performance based measurement; prevent; preventive intervention; psychosocial; public health relevance; social; substance use; substance use prevention; young adult

Project Summary Adolescent substance use is a prevalent and significant public health concern. Although gains have been made in the development of effective substance use preventive interventions, there is room for improvement. Intervention refinements must be based on additional longitudinal research of developmental precursors that emerge well before substance use onset. Deficits in executive control (EC), a set of cognitive abilities for directing attention and behavior, have been proposed as important and modifiable contributors to adolescent problem behaviors, including substance use as well as co-occurring externalizing and internalizing problems. However, the early-emerging and dynamically-unfolding role of EC in the development of substance use and related problems is not well understood. Existing research lacks a long-term, developmentally-nuanced perspective, precluding an understanding of when and how poor EC impacts substance use risk. Preschool is a time of significant EC organization. Adolescence is a time of further EC development and differentiation, and the emergence of substance use. Yet, relevant studies spanning these critical developmental periods are lacking. This application proposes to extend an ongoing study of young children and their parents followed during preschool and the elementary school years with intensive, repeated, performance-based measures of EC (along with multi-rater, multi-method assessments of a broad array of additional factors) by collecting new data at ages 14, 15, 16, and 17. The long-term goal is to guide the development and refinement of substance use preventive interventions targeting EC as a modifiable risk factor at critical points in development. The objective of the proposed research is to explicate the long-term, dynamic impact of EC on the development of substance use and co-occurring problems. The central hypotheses are that poor EC in preschool, throughout childhood, and into adolescence will be related to the onset and growth of substance use and problem co- occurrence, and that these associations will be at least partially mediated by social developmental processes. The rationale is that a nuanced, longitudinal study of EC and substance use will richly inform the timing and targets of interventions focusing on EC to prevent adolescent substance use and related problems. The specific aims are to examine the long-term impact of EC in preschool (Aim 1) as well as the development of EC throughout childhood and adolescence (Aim 2) on adolescent substance use and co-occurring internalizing and externalizing problems, testing family, school, and peer mediating mechanisms (Aim 3) and exploring gender moderation (Exploratory Aim). The proposed project is innovative in its unique leveraging of early EC data from the sample and its rigorous and multifaceted measurement of EC over critical developmental periods. The significance of this research is that it will yield an unprecedented understanding of the impact of EC on substance use, affording new insights into when and how EC has its effects and providing information for designing optimally-timed, targeted interventions to bolster EC and prevent adolescent substance use.

项目摘要 青少年药物使用是一个普遍和重大的公共卫生问题。虽然收益已 在制定有效的药物使用预防干预措施方面，还有改进的余地。 干预措施的改进必须基于对发展前兆的进一步纵向研究， 在吸毒前就出现了执行控制（EC）缺陷，一组认知能力， 引导注意力和行为，已被提出作为重要的和可改变的贡献者，青少年 问题行为，包括物质使用以及共同发生的外部化和内部化问题。 然而，早期出现和动态展开的作用，欧共体在发展的物质使用和 相关的问题还不太清楚。现有的研究缺乏长期的，发展上的细微差别， 从这个角度来看，排除了对不良EC何时以及如何影响物质使用风险的理解。学前教育是 一个重要的EC组织的时间。青春期是EC进一步发展和分化的时期， 物质使用的出现。然而，跨越这些关键发展时期的相关研究 缺乏这项申请建议延长正在进行的研究幼儿和他们的父母以下 在学龄前和小学期间， EC（沿着对一系列其他因素的多评分者、多方法评估）， 14岁、15岁、16岁和17岁的数据。长期目标是指导实质的发展和完善 在发展的关键点上，将针对EC的预防性干预措施作为可改变的风险因素。的 拟议研究的目标是阐明电子商务对发展的长期动态影响， 物质使用和共同发生的问题。中心假设是，在整个学前教育中， 儿童期，进入青春期将与物质使用和问题的发生和增长有关， 发生，这些协会将至少部分介导的社会发展进程。 理由是，一个微妙的，纵向研究EC和物质使用将丰富地告知时间和 以预防青少年药物使用和相关问题为重点的干预措施的目标。的 具体目的是研究幼儿教育对幼儿园的长远影响（目的1），以及幼儿教育的发展 在整个童年和青春期（目标2）关于青少年物质使用和共同发生的内化 和外部化问题，测试家庭，学校和同伴调解机制（目标3），并探索 性别适度（探索性目标）。建议的项目在其独特的早期EC杠杆作用方面具有创新性 从样本的数据及其严格和多方面的测量EC超过关键的发展 时期这项研究的重要性在于，它将产生一个前所未有的了解的影响， 欧盟委员会关于物质使用的报告，就欧盟委员会何时以及如何产生影响提供新的见解，并提供信息 设计最佳时机，有针对性的干预措施，以加强EC和防止青少年物质使用。

项目成果

Childhood executive control and adolescent substance use initiation: the mediating roles of physical and relational aggression and prosocial behavior.

童年执行控制和青少年物质使用开始：身体和关系攻击以及亲社会行为的中介作用。

• DOI: 10.1080/09297049.2022.2079615
• 发表时间: 2023
• 期刊: Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence
• 作者: Patwardhan,Irina;Guo,Ying;Hamburger,EmilyR;Sarwar,Saira;Fleming,CharlesB;James,TiffanyD;Nelson,JenniferMize;Espy,KimberlyAndrews;Nelson,TimothyD;Mason,WAlex
• 通讯作者: Mason,WAlex

Executive Control in Early Childhood as an Antecedent of Adolescent Problem Behaviors: A Longitudinal Study with Performance-based Measures of Early Childhood Cognitive Processes.

• DOI: 10.1007/s10964-020-01316-9
• 发表时间: 2020-12
• 期刊: Journal of youth and adolescence
• 影响因子: 4.9
• 作者: Fleming CB;Stevens AL;Vivero M;Patwardhan I;Nelson TD;Nelson JM;James TD;Espy KA;Mason WA
• 通讯作者: Mason WA

A Comparison of Task-Based and Questionnaire Assessments of Executive Control Aspects in Relation to Adolescent Marijuana Initiation.

• DOI: 10.26828/cannabis/2023.01.006
• 发表时间: 2023-02-07
• 期刊: Cannabis (Albuquerque, N.M.)

Associations of childhood executive control with adolescent cigarette and E-cigarette use: Tests of moderation by poverty level.

• DOI: 10.1016/j.addbeh.2021.106923
• 发表时间: 2021-08
• 期刊: Addictive behaviors
• 影响因子: 4.4
• 作者: Alex Mason W;Patwardhan I;Fleming CB;Stevens AL;James TD;Nelson JM;Espy KA;Nelson TD
• 通讯作者: Nelson TD

Associations of Early Socio-familial Stress with Maladaptive and Adaptive Functioning in Middle Childhood: Roles of Executive Control and Foundational Cognitive Abilities.

早期社会家庭压力与童年中期适应不良和适应性功能的关联：执行控制和基础认知能力的作用。

• DOI: 10.1007/s11121-020-01119-1
• 发表时间: 2020
• 期刊: Prevention science : the official journal of the Society for Prevention Research
• 作者: Mason,WAlex;Fleming,CharlesB;Tomaso,CaraC;James,TiffanyD;Nelson,JenniferMize;Espy,KimberlyAndrews;Nelson,TimothyD
• 通讯作者: Nelson,TimothyD