Role of Childhood Cumulative Risk in Substance Misuse and Co-occurring Problems

童年累积风险在药物滥用和并发问题中的作用

• 批准号: 9064121
• 负责人: W Alex Mason
• 金额: $ 24.1万
• 依托单位: FATHER FLANAGAN'S BOYS' HOME
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9064121
• 关键词: Address; Adolescence; Adolescent; Adolescent and Young Adult; Alcohol or Other Drugs use; Applications Grants; Belief; Birth; Buffers; Childhood; Cohort Studies; Comorbidity; Data; Data Analyses; Data Set; Data Sources; Development; Developmental Process; Finland; Gender; Health; Health Benefit; Impairment; Intervention; Knowledge; Left; Measures; Mediating; Mediator of activation protein; Mental Depression; Mission; Modeling; Morbidity - disease rate; National Institute of Drug Abuse; Nature; Outcome; Parents; Pathway interactions; Process; Provider; Public Health; Research; Research Personnel; Rewards; Risk; Risk Factors; Role; Sample Size; Sampling; Services; Social Development; Source; Specific qualifier value; Testing; Time; Translating; Translations; United States National Institutes of Health; Universities; Youth; anti social; base; cohort; cost effective; data registry; early onset; emerging adult; experience; gender difference; high risk; improved outcome; informant; innovation; longitudinal design; mortality; population survey; prenatal; programs; prospective; resilience; selective prevention; skills; social; socioeconomic disadvantage; substance misuse; substance misuse prevention; teacher; therapy design

DESCRIPTION (provided by applicant): Vulnerability for substance misuse is highest among youth who experience multiple contextual risks, such as birth-related risks and socioeconomic disadvantage, during early development. Indeed, cumulative risk, defined as the number of contextual risk factors independent of the presence or absence of any particular risk, is a robust predictor of adolescent and young adult substance misuse. However, there are significant gaps in knowledge about the associations of cumulative contextual risk with substance misuse. Cumulative risk often has been studied as a static phenomenon, therefore the degree to which such risk accumulates both within and across time is unknown. Moreover, research in the cumulative risk tradition typically has examined substance misuse as a singular outcome, yet substance misuse often co-occurs with externalizing and internalizing problems. Importantly, potential mediating mechanisms and moderating influences infrequently have been considered in analyses of cumulative risk effects on substance misuse, and gender moderation rarely has been tested. Substance misuse is a prevalent public health concern, and substance misuse comorbidity is associated with heightened impairment compared to singular problems; thus, additional research is needed. The current grant application helps address these gaps by proposing to study cumulative contextual risk both within and across time during early development in relation to substance misuse and co- occurring externalizing and internalizing problems in adolescence and early adulthood (Aim 1). Social developmental mediators will be examined as intervening mechanisms (Aim 2a) and tests of social developmental moderators hypothesized to buffer risk (Aim 2b) will be conducted using existing longitudinal data from the 1986 Northern Finland Birth Cohort Study (NFBCS). The NFBCS is a large-scale birth cohort study with multi-informant (parent, teacher, adolescent), multi-source (surveys, population registries) data collected on a sample of 9,432 youth followed from the prenatal period to the 20s. Guided by the social development model (SDM), the central hypotheses are that there will be positive associations of cumulative risk with adolescent and young adult substance misuse and co-occurring problems, and that those associations will be mediated through SDM risk processes; SDM protective factors will serve as buffering moderators. Gender differences also will be explored. This application is highly innovative. The NFBCS is a unique, large-scale birth cohort study with an exceptionally broad range of biopsychological and social contextual assessments ideal for studying general risk and resilience processes. Aims of the proposed study will be accomplished by an interdisciplinary team of investigators from both university and service provider settings to facilitate translation of findings into practice. Study findings hold promise for helping to promote resilience in the face of risk among vulnerable youth by elucidating potentially malleable mediators and moderators to target in selective preventive interventions.

描述（由申请人提供）：在早期发育期间经历多种背景风险（例如出生相关风险和社会经济劣势）的青少年中，药物滥用的脆弱性最高。事实上，累积风险（定义为独立于是否存在任何特定风险的背景风险因素的数量）是青少年和年轻人药物滥用的有力预测因素。然而，对于累积背景风险与药物滥用之间的关联，人们的认识还存在重大差距。累积风险通常被作为一种静态现象来研究，因此这种风险在一段时间内和跨时间累积的程度是未知的。此外，累积风险传统的研究通常将药物滥用视为单一结果，但药物滥用通常与外化和内化问题同时发生。重要的是，在分析药物滥用的累积风险影响时很少考虑潜在的中介机制和调节影响，并且很少测试性别调节。药物滥用是一个普遍的公共卫生问题，与单一问题相比，药物滥用合并症与严重损害相关；因此，需要进行更多研究。目前的拨款申请建议研究早期发育过程中与物质滥用以及青春期和成年早期同时发生的外化和内化问题相关的累积背景风险，有助于弥补这些差距（目标 1）。社会发展调节因素将作为干预机制进行审查（目标 2a），并且将使用 1986 年北芬兰出生队列研究 (NFBCS) 的现有纵向数据对假设缓冲风险的社会发展调节因素进行测试（目标 2b）。 NFBCS 是一项大规模出生队列研究，收集了 9,432 名青少年从产前到 20 多岁的样本，收集了多信息对象（家长、教师、青少年）、多来源（调查、人口登记）数据。在社会发展模型（SDM）的指导下，中心假设是累积风险与青少年和年轻人物质滥用以及同时发生的问题之间存在正相关关系，并且这些关联将通过 SDM 风险流程进行调节； SDM 保护因素将充当缓冲调节剂。性别差异也将被探讨。该应用程序具有高度创新性。 NFBCS 是一项独特的大规模出生队列研究，具有极其广泛的生物心理学和社会背景评估，非常适合研究一般风险和复原力过程。拟议研究的目标将由来自大学和服务提供商环境的跨学科研究人员团队来完成，以促进将研究结果转化为实践。研究结果有望通过阐明选择性预防干预措施中潜在的可塑性调解者和调节者来帮助提高弱势青少年面对风险时的复原力。

项目成果

Childhood cumulative contextual risk and depression diagnosis among young adults: The mediating roles of adolescent alcohol use and perceived social support.

年轻人的童年累积背景风险和抑郁症诊断：青少年饮酒和感知社会支持的中介作用。

• DOI: 10.1016/j.adolescence.2017.07.008
• 发表时间: 2017
• 期刊: Journal of adolescence
• 影响因子: 3.8
• 作者: Patwardhan,Irina;Mason,WAlex;Savolainen,Jukka;Chmelka,MaryB;Miettunen,Jouko;Järvelin,Marjo-Riitta
• 通讯作者: Järvelin,Marjo-Riitta

The path from childhood behavioural disorders to felony offending: Investigating the role of adolescent drinking, peer marginalisation and school failure.

从儿童行为障碍到重罪的路径：调查青少年饮酒、同伴边缘化和学业失败的作用。

• DOI: 10.1002/cbm.1931
• 发表时间: 2015
• 期刊: Criminal behaviour and mental health : CBMH
• 作者: Savolainen,Jukka;Mason,WAlex;Bolen,JonathanD;Chmelka,MaryB;Hurtig,Tuula;Ebeling,Hanna;Nordström,Tanja;Taanila,Anja
• 通讯作者: Taanila,Anja

Does Educational Marginalization Mediate the Path from Childhood Cumulative Risk to Criminal Offending?

教育边缘化是否介导了从童年累积风险到刑事犯罪的路径？

• DOI: 10.1007/s40865-017-0062-9
• 发表时间: 2017
• 期刊: Journal of developmental and life-course criminology
• 影响因子: 1.9
• 作者: Solomon,StarrJ;Savolainen,Jukka;Mason,WAlex;Miettunen,Jouko;January,Stacy-AnnA;Järvelin,Marjo-Riitta
• 通讯作者: Järvelin,Marjo-Riitta

Associations of Cumulative Family Risk With Academic Performance and Substance Involvement: Tests of Moderation by Child Reading Engagement.

累积家庭风险与学业成绩和物质参与的关联：儿童阅读参与度的调节测试。

• DOI: 10.1080/10826084.2019.1608248
• 发表时间: 2019
• 期刊: Substance use & misuse
• 影响因子: 2
• 作者: Mason,WAlex;Chmelka,MaryB;Patwardhan,Irina;January,Stacy-AnnA;Fleming,CharlesB;Savolainen,Jukka;Miettunen,Jouko;Järvelin,Marjo-Riitta
• 通讯作者: Järvelin,Marjo-Riitta