Novel 18F and 64Cu labelled targeted nanoparticles for molecular positron emission tomography: A means for early and sensitive detection of thrombosis, inflammation and vulnerable, rupture-prone atherosclerotic plaques

用于分子正电子发射断层扫描的新型 18F 和 64Cu 标记靶向纳米颗粒：一种早期、灵敏检测血栓形成、炎症和脆弱、易破裂动脉粥样硬化斑块的方法

• 批准号: nhmrc : 1029249
• 负责人: A/Pr Christoph Hagemeyer
• 金额: $ 38.2万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-18f-64cu-atherosclerotic-plaques/110679
• 关键词: Novel; 18F; 64Cu; labelled; targeted

The aim of this project is to develop novel targeted positron emission tomography imaging agents that seek out specific markers for various states of cardiovascular disease. These agents would provide a method for detecting the presence and level of atherosclerosis and thrombotic events. The targeted nanoparticles may provide a unique opportunity to detect very early plaques and the vulnerability of existing plaques.

该项目的目的是开发新型靶向正电子发射断层扫描成像剂，以寻找各种心血管疾病状态的特异性标志物。这些试剂将提供用于检测动脉粥样硬化和血栓形成事件的存在和水平的方法。靶向纳米颗粒可以提供一个独特的机会来检测非常早期的斑块和现有斑块的脆弱性。