Novel Single-chain antibody-targeted nanoparticles for diagnosis of vascular diseases

用于诊断血管疾病的新型单链抗体靶向纳米颗粒

• 批准号: nhmrc : 472668
• 负责人: A/Pr Christoph Hagemeyer
• 金额: $ 25.38万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-single-chain-vascular-diseases/115357
• 关键词: Novel; Single; chain; antibody; targeted

The aim of this project is to develop targeted imaging agents that seek out specific markers for various states of cardiovascular disease. These agents would provide a method for detecting the presence and level of atherosclerosis, fatty tissue build up in the vessel wall. The nanoparticles may provide a unique opportunity to detect very early plaques, the vulnerability of existing plaques and difficult-to-diagnose vessel blockages such as clots in lung vessels (pulmonary embolism).

该项目的目的是开发有针对性的显像剂，寻找各种心血管疾病状态的特定标记物。这些药物将提供一种检测动脉粥样硬化的存在和水平的方法，动脉粥样硬化是血管壁中脂肪组织的形成。纳米颗粒可能提供一个独特的机会来检测早期斑块，现有斑块的脆弱性和难以诊断的血管阻塞，如肺血管中的凝块（肺栓塞）。