Delivering nanoparticles to prevent rupture of unstable arterial plaques

输送纳米颗粒以防止不稳定动脉斑块破裂

• 批准号: nhmrc : GNT1078118
• 负责人: A/Pr Christoph Hagemeyer
• 金额: $ 59.38万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/delivering-nanoparticles-prevent-arterial-plaques/1345191
• 关键词: Delivering; nanoparticles; prevent; rupture; unstable

The aim of this project is to develop an immune-mediated ‘smart bomb’ concept of drug delivery into atherosclerotic plaques for the prevention of plaque rupture. An overwhelming majority of fatal heart attacks and sudden death all over the world result from plaque rupture; making this research highly important in finding a bio-technologically advanced way of preventing heart attacks and sudden death in patients with coronary artery disease.

该项目的目的是开发一种免疫介导的“智能炸弹”概念，将药物递送到动脉粥样硬化斑块中以预防斑块破裂。全世界绝大多数致命的心脏病发作和猝死都是由斑块破裂引起的;这使得这项研究在寻找预防冠状动脉疾病患者心脏病发作和猝死的生物技术先进方法方面非常重要。