A Confirmatory Efficacy Study of Interoceptive Exposure for Adolescents with Low Weight Eating Disorders
内感受暴露对低体重饮食失调青少年的有效性研究
基本信息
- 批准号:10571565
- 负责人:
- 金额:$ 78.62万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-02-01 至 2028-01-31
- 项目状态:未结题
- 来源:
- 关键词:AbbreviationsAddressAdolescenceAdolescentAftercareAgeAnorexia NervosaAttitudeAwarenessBehavioralBlindedBody WeightChildChild RearingChronicClinicalCost of IllnessCuesDataData AnalysesDevelopmentDistalEatingEating BehaviorEating DisordersElectrophysiology (science)Eligibility DeterminationEtiologyEvaluationExposure toExtinctionFamilyFamily psychotherapyFoodFoundationsHealth Care CostsImpairmentInterventionLaboratoriesLearningMeasuresMediatingMediationMediatorMeta-AnalysisModelingOccupationsOutcomeParticipantPathologyPatientsPharmaceutical PreparationsProtocols documentationPublic HealthPublishingRandomized Controlled Clinical TrialsSelf EfficacyShapesSymptomsTestingTimeTreatment EfficacyWeightagedcomparative efficacyconditioningconfirmatory trialdepressive symptomsefficacy evaluationefficacy studyefficacy testingefficacy trialexperiencefeedingfollow-upfood avoidanceimprovedlearning extinctionlongitudinal datasetnovelprimary outcomesecondary outcomesevere psychiatric disordersexstandard caresuccesssystematic reviewtreatment adherencetreatment comparisontreatment effecttreatment response
项目摘要
Project Summary/Abstract
Low weight eating disorders, such as anorexia nervosa/atypical anorexia nervosa, are severe psychiatric
disorders that often develop in adolescence, have a chronic course, and evidence poor response to treatment
at great public health cost. Two core features of LW-EDs are food avoidance and preoccupation with shape
and weight. Preliminary data from our initial mechanism study indicate that family based interoceptive
exposure (FBT-E) therapy reduces food avoidance, increases autonomous eating and nonjudgement body
awareness, and enhances extinction learning to aversive food cues to a greater degree than existing family-
based therapy (FBT). Feasibility data indicated high retention, treatment fidelity, and established reliable
measures of treatment adherence despite similar short-term (6-week) within-treatment changes in expected
body weight. Long-term (6-month) follow-up of these interventions in open trial indicate significantly higher
expected body weight among those having received FBT-E. Short-term and long-term changes in weight were
highly correlated with changes in expected body weight. Consequently, we will test the confirmatory efficacy of
FBT-E vs FBT and 12-month follow-up in a parallel group randomized clinical controlled trial in 120
adolescents aged 12-18. We have three specific aims, including: (1) to determine short term and long term
efficacy of FBT-E vs FBT in expected body weight, global eating disorder symptoms, and clinical impairment;
(2) to determine efficacy of FBT-E vs. FBT on laboratory measures of autonomous eating, nonjudgmental body
awareness, and extinction learning; and (3) estimate whether temporal precedence and mechanistic value
(mediation) of early changes in autonomous eating, non-judgmental body awareness, and extinction learning
on treatment effects and longitudinal outcomes. Assessments and data analyses will be blinded to treatment.
With N=120 participants (n = 60 per group) we can detect moderate sized effects for primary and secondary
outcomes. Results will provide data to support novel treatment for LW-EDs and provide theoretical robust
model for understanding pathology for children and families that suffer with LW-EDs.
项目概要/摘要
低体重饮食失调,例如神经性厌食症/非典型神经性厌食症,是严重的精神疾病
通常在青春期出现的疾病,有慢性病程,并且对治疗的反应不佳
以巨大的公共卫生成本为代价。 LW-ED 的两个核心特征是回避食物和关注形状
和重量。我们初步机制研究的初步数据表明,基于家庭的内感受
暴露(FBT-E)疗法减少食物回避,增强自主进食和不评判身体
意识,并比现有家庭更大程度地增强对厌恶食物线索的灭绝学习
基于治疗(FBT)。可行性数据表明高保留率、治疗保真度,并建立了可靠的
尽管预期的短期(6周)治疗内变化相似,但治疗依从性的衡量标准
体重。开放试验中这些干预措施的长期(6 个月)随访表明,
接受 FBT-E 的人的预期体重。体重的短期和长期变化
与预期体重的变化高度相关。因此,我们将测试验证功效
FBT-E 与 FBT 对比以及 120 名受试者参加的平行组随机临床对照试验中的 12 个月随访
12-18岁的青少年。我们有三个具体目标,包括:(1)确定短期和长期
FBT-E 与 FBT 在预期体重、整体饮食失调症状和临床损伤方面的疗效;
(2) 确定 FBT-E 与 FBT 对自主饮食、非评判性身体实验室测量的功效
意识和灭绝学习; (3) 估计时间优先级和机械价值是否
(调解)自主饮食、非评判性身体意识和灭绝学习的早期变化
关于治疗效果和纵向结果。评估和数据分析将对治疗不知情。
对于 N=120 名参与者(每组 60 名),我们可以检测到主要和次要的中等程度的影响
结果。结果将为支持 LW-ED 的新治疗方法提供数据,并提供稳健的理论
理解患有 LW-ED 的儿童和家庭的病理学模型。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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THOMAS B HILDEBRANDT其他文献
THOMAS B HILDEBRANDT的其他文献
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{{ truncateString('THOMAS B HILDEBRANDT', 18)}}的其他基金
General Brain Arousal and Risk for Eating Disorder
一般大脑唤醒和饮食失调的风险
- 批准号:
10365378 - 财政年份:2021
- 资助金额:
$ 78.62万 - 项目类别:
General Brain Arousal and Risk for Eating Disorder
一般大脑唤醒和饮食失调的风险
- 批准号:
10656518 - 财政年份:2021
- 资助金额:
$ 78.62万 - 项目类别:
Reward Systems and Food Avoidance in Adolescents with Low Weight Eating Disorders
低体重饮食失调青少年的奖励制度和食物避免
- 批准号:
9334942 - 财政年份:2016
- 资助金额:
$ 78.62万 - 项目类别:
Reward Systems and Food Avoidance in Adolescents with Low Weight Eating Disorders
低体重饮食失调青少年的奖励系统和食物避免
- 批准号:
10222953 - 财政年份:2016
- 资助金额:
$ 78.62万 - 项目类别:
Innovative Use of the Noom Monitor Mobile Application for CBT-GSH in Binge Eaters
Noom Monitor 移动应用程序在暴食者中创新地使用 CBT-GSH
- 批准号:
8521678 - 财政年份:2013
- 资助金额:
$ 78.62万 - 项目类别:
Innovative Use of the Noom Monitor Mobile Application for CBT-GSH in Binge Eaters
Noom Monitor 移动应用程序在暴食者中创新地使用 CBT-GSH
- 批准号:
8665495 - 财政年份:2013
- 资助金额:
$ 78.62万 - 项目类别:
Bio-behavioral Consequences of Appearance and Performance Enhancing Drug Use
外观和性能增强药物使用的生物行为后果
- 批准号:
8269936 - 财政年份:2008
- 资助金额:
$ 78.62万 - 项目类别:
Bio-behavioral Consequences of Appearance and Performance Enhancing Drug Use
外观和性能增强药物使用的生物行为后果
- 批准号:
7530230 - 财政年份:2008
- 资助金额:
$ 78.62万 - 项目类别:
Bio-behavioral Consequences of Appearance and Performance Enhancing Drug Use
外观和性能增强药物使用的生物行为后果
- 批准号:
8081856 - 财政年份:2008
- 资助金额:
$ 78.62万 - 项目类别:
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