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Reward Systems and Food Avoidance in Adolescents with Low Weight Eating Disorders

低体重饮食失调青少年的奖励系统和食物避免

基本信息

批准号：
10222953
负责人：
THOMAS B HILDEBRANDT
金额：
$ 22.09万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-19 至 2021-08-31
项目状态：
已结题

项目摘要

Project Summary Low weight eating disorders are severe psychiatric disorders that most often develop in adolescence, have a chronic course, and evidence poor response to treatment. This project examined the hypothesis that the insula-amygdala-ventral striatum (IAVS) neurocircuit is responsible for abhorrent food-cue learning in adolescents with LW-EDs and that this learning underlies the core construct of food avoidance. We tested this hypothesis by experimentally manipulating the functionally connectivity of this neurocircuit by utilization of novel clinical treatment, family based interoceptive exposure (FBT-IE) vs. standard family therapy. To delineate this aversive neurocircuit, we utilized novel computational approach integrating facial electromyography into the fMRI of food-cue reversal learning task. This fMRI-EMG was designed to empirically establish aversive responses to food-cues among patients and pleasurable responses to food avoidance. We sought to distinguish pathological responses of the IAVS neurocircuit and its relationship to affective response from healthy controls, establishing the neurocircuit as a key source for divergences in eating, clinical symptoms, and behavior between groups. In addition, we sought to test weather FBT-IE leads to differential changes in clinical, laboratory eating, neurocircuit, and behavioral responses to food cues. At this point, we have completed data collection on 60 patients with LW-EDs and 22 health controls. We have begun analyzing the clinical data. However, 2 of our controls were lost to COVID disruption and 7 of the remaining 20 have incomplete or compromised data. Due to the suspension of activities, we will run out of funding before the end of the NCE because of our efforts to pay staff through the COVID related suspensions. Consequently, this proposed supplement seeks funds to support to staff to complete data collection for the healthy control subjects (8 new subjects, 2 replaced from COVID loss, and 7 replacement of compromised existing data, totaling 17 new healthy control subjects.)

项目摘要低体重进食障碍是严重的精神疾病，最常见于青春期，慢性病程，对治疗反应差。该项目研究了假设，胰岛-杏仁核-腹侧纹状体（IAVS）神经回路负责异常食物线索学习， LW-ED的青少年，这种学习是避免食物的核心结构的基础。我们测试了这个通过实验操纵这个神经回路的功能连接，利用新的临床治疗，基于家庭的内感受性暴露（FBT-IE）与标准家庭治疗。到描绘这种厌恶的神经回路，我们利用新的计算方法整合面部 fMRI的食物线索逆转学习任务。该fMRI-EMG旨在经验性地建立患者对食物线索的厌恶反应和对食物的愉快反应回避我们试图区分IAVS神经回路的病理反应及其与健康对照组的情感反应，建立神经回路作为分歧的关键来源，进食、临床症状和行为。此外，我们试图测试天气FBT-IE铅临床、实验室进食、神经回路和对食物线索的行为反应的差异变化。在这个在这一点上，我们已经完成了60例LW-ED患者和22例健康对照的数据收集。我们已经开始分析临床数据。然而，我们的控制措施中有2项因COVID中断而失去，其余20项中有7项不完整或受损的数据。由于活动暂停，我们将在新冠肺炎疫情结束，因为我们努力通过与COVID相关的停职支付员工工资。因此，委员会认为，这一拟议的补充申请寻求资金，以支持工作人员完成健康控制的数据收集。受试者（8名新受试者，2名因COVID损失而被替换，7名替换受损的现有数据，共17名新的健康对照受试者。