Bio-behavioral Consequences of Appearance and Performance Enhancing Drug Use

描述(由申请人提供)：建议的K23患者导向职业发展奖旨在为PI提供必要的培训，以研究使用外貌和表现增强药物(APED)在生物行为后果方面的个体差异。候选人：PI是一名助理教授和执业临床心理学家，目前在西奈山医学院(MSSM‘s)饮食和体重障碍项目工作。他计划使用K23成为R01资助的研究人员，与基础科学家和翻译科学家密切合作，解决APED使用带来的临床、伦理和科学挑战。为了实现这些职业目标，他将使用K23获得必要的知识、技能和能力，以研究APED使用者的内分泌/神经内分泌功能和攻击性/冲动之间的关系。他的具体培训目标是(A)学习研究APED使用的病理和非病理形式之间的区别的理论、方法和临床方法，(B)发展通过翻译研究获得的理论和方法的实用知识，以研究激素与行为的关系，(C)获得将激素失调与精神疾病联系起来的理论和方法方面的专业知识，(D)更好地了解与研究药物滥用相关的医学、法律和伦理问题，以及(E)获得生物数据的纵向数据建模和统计分析方面的专业知识。环境：PI提出的培训计划和职业目标与MSSM精神病学系整合翻译和临床研究的使命声明是一致的，特别是在神经内分泌学领域。希尔德布兰特博士拥有丰富的专业知识和可用的资源，包括研究内分泌和神经内分泌功能所需的实验室。研究：使用类人猿最可靠的精神后果是增加冲动攻击性，尽管已经观察到一系列精神障碍。这项有监督的研究项目将对60名成年雄性类人猿使用者在不同时间(周期内和周期外)的激素和精神调节失调(攻击性和冲动性)程度进行纵向研究，并与20名年龄、锻炼和教育相匹配的对照组进行比较。分段潜在增长曲线模型将用于研究周期内和周期外的变化，并将探索以下变化的预测因素：APED特征(数量、持续时间和模式)、年龄、精神病史、个性和APED使用史)。相关性：拟议研究的结果将有助于确定导致APED使用的精神后果的内分泌功能障碍，以及预测这些精神后果的使用者特征。这项研究的意义在于为与这一日益增长的公共卫生问题相关的预防、干预和基于政策的决策提供信息。

DESCRIPTION (provided by applicant): The proposed K23 Patient-Oriented Career Development Award is designed to provide the PI with the training necessary to study the individual variability in bio-behavioral consequences of appearance and performance enhancing drug (APED) use. Candidate: The PI is an Assistant Professor and licensed clinical Psychologist currently working at the Mount Sinai School of Medicine's (MSSM's) Eating and Weight Disorders Program. He plans to use the K23 to become an R01 funded researcher that works closely with basic and translational scientists on the clinical, ethical, and scientific challenges presented by APED use. In order to obtain these career goals, he will use the K23 to acquire knowledge, skills, and abilities necessary to the study the relationship between endocrine/neuroendocrine function and aggression/impulsivity among APED users. His specific training objectives are to (a) learn the theoretical, methodological, and clinical approaches to studying the distinction between pathological and non-pathological forms of APED use, (b) develop a working knowledge of the theory and methodology available through translational research to study hormone-behavior relationships, (c) acquire expertise in the theory and methodology linking hormone dysregulation to psychiatric illness, (d) acquire greater understanding of the medical, legal, and ethical issues associated with studying substance abuse, and (e) obtain expertise in longitudinal data modeling and statistical analysis of biological data. Environment: The Pi's proposed training plan and career goals are consistent with the MSSM Department of Psychiatry's mission statement to integrate translational and clinical research, particularly in the area of neuroendocrinology. Dr. Hildebrandt has available to him a wealth of expertise and resources available including the lab facilitates necessary to study both endocrine and neuroendocrine functioning. Research: The most reliable psychiatric consequence to APED use is increased impulsive aggression although a range of psychiatric disturbances have been observed. The supervised research project will be a longitudinal study of the degree of both hormone and psychiatric dysregulation (aggression and impulsivity) in 60 adult male APED users across time (on-cycle and off-cycle) compared to 20 age, exercise, and education matched controls. Piecewise latent growth curve modeling will be used to investigate changes on-cycle and off-cycle changes and the following predictors of change will be explored: APED characteristics (amount, duration, and pattern), Age, Psychiatric History, Personality, & History of APED use). Relevance: Findings from the proposed study will help identify both the endocrine dysfunction responsible for the psychiatric consequences to APED use and the user characteristics predictive of these psychiatric consequences. Implications of this research are to inform prevention, intervention, and policy based decisions related to this growing public health concern.