Bio-behavioral Consequences of Appearance and Performance Enhancing Drug Use

描述（由申请人提供）：拟议的K23以患者为导向的职业发展奖旨在为PI提供必要的培训，以研究使用外表和表现增强药物（APED）的生物行为后果的个体差异。候选人：PI是一名助理教授和持牌临床心理学家，目前在西奈山医学院（MSSM）饮食和体重失调项目工作。他计划使用K23成为一名R 01资助的研究人员，与基础和转化科学家密切合作，解决使用APED所带来的临床、伦理和科学挑战。为了实现这些职业目标，他将使用K23获得必要的知识，技能和能力，以研究内分泌/神经内分泌功能与APED用户之间的攻击/冲动之间的关系。他的具体培训目标是：（a）学习理论、方法和临床方法，以研究病理和非病理形式的APED使用之间的区别，（B）通过转化研究开发理论和方法的工作知识，以研究自杀-行为关系，（c）获得将激素失调与精神疾病联系起来的理论和方法方面的专业知识，（d）更好地理解与研究药物滥用相关的医学、法律的和伦理问题，以及（e）获得纵向数据建模和生物数据统计分析方面的专业知识。工作环境：Pi提出的培训计划和职业目标与MSSM精神病学系的使命声明一致，以整合转化和临床研究，特别是在神经内分泌学领域。Hildebrandt博士拥有丰富的专业知识和资源，包括实验室，为研究内分泌和神经内分泌功能提供了必要的便利。研究：使用APED最可靠的精神后果是冲动性攻击增加，尽管已经观察到一系列精神障碍。监督的研究项目将是一项纵向研究的激素和精神失调（侵略和冲动）的程度在60个成年男性APED用户跨时间（周期和周期）相比，20个年龄，运动和教育匹配的控制。将使用分段潜伏生长曲线模型研究周期内和周期外的变化，并探索以下变化预测因素：APED特征（数量、持续时间和模式）、年龄、精神病史、个性和APED使用史。相关性：拟议研究的结果将有助于确定内分泌功能障碍对使用APED的精神后果负责，以及预测这些精神后果的用户特征。这项研究的意义是告知预防，干预和政策为基础的决策，这一日益增长的公共卫生问题。

DESCRIPTION (provided by applicant): The proposed K23 Patient-Oriented Career Development Award is designed to provide the PI with the training necessary to study the individual variability in bio-behavioral consequences of appearance and performance enhancing drug (APED) use. Candidate: The PI is an Assistant Professor and licensed clinical Psychologist currently working at the Mount Sinai School of Medicine's (MSSM's) Eating and Weight Disorders Program. He plans to use the K23 to become an R01 funded researcher that works closely with basic and translational scientists on the clinical, ethical, and scientific challenges presented by APED use. In order to obtain these career goals, he will use the K23 to acquire knowledge, skills, and abilities necessary to the study the relationship between endocrine/neuroendocrine function and aggression/impulsivity among APED users. His specific training objectives are to (a) learn the theoretical, methodological, and clinical approaches to studying the distinction between pathological and non-pathological forms of APED use, (b) develop a working knowledge of the theory and methodology available through translational research to study hormone-behavior relationships, (c) acquire expertise in the theory and methodology linking hormone dysregulation to psychiatric illness, (d) acquire greater understanding of the medical, legal, and ethical issues associated with studying substance abuse, and (e) obtain expertise in longitudinal data modeling and statistical analysis of biological data. Environment: The Pi's proposed training plan and career goals are consistent with the MSSM Department of Psychiatry's mission statement to integrate translational and clinical research, particularly in the area of neuroendocrinology. Dr. Hildebrandt has available to him a wealth of expertise and resources available including the lab facilitates necessary to study both endocrine and neuroendocrine functioning. Research: The most reliable psychiatric consequence to APED use is increased impulsive aggression although a range of psychiatric disturbances have been observed. The supervised research project will be a longitudinal study of the degree of both hormone and psychiatric dysregulation (aggression and impulsivity) in 60 adult male APED users across time (on-cycle and off-cycle) compared to 20 age, exercise, and education matched controls. Piecewise latent growth curve modeling will be used to investigate changes on-cycle and off-cycle changes and the following predictors of change will be explored: APED characteristics (amount, duration, and pattern), Age, Psychiatric History, Personality, & History of APED use). Relevance: Findings from the proposed study will help identify both the endocrine dysfunction responsible for the psychiatric consequences to APED use and the user characteristics predictive of these psychiatric consequences. Implications of this research are to inform prevention, intervention, and policy based decisions related to this growing public health concern.