Bio-behavioral Consequences of Appearance and Performance Enhancing Drug Use

外观和性能增强药物使用的生物行为后果

基本信息

项目摘要

The proposed K23 Patient-Oriented Career Development Award is designed to provide the PI with the training necessary to study the individual variability in bio-behavioral consequences of appearance and performance enhancing drug (APED) use. Candidate: The PI is an Assistant Professor and licensed clinical Dsychologist currently working at the Mount Sinai School of Medicine's (MSSM's) Eating and Weight Disorders Program. He plans to use the K23 to become an R01 funded researcher that works closely with basic and translational scientists on the clinical, ethical, and scientific challenges presented by APED use. In order to obtain these career goals, he will use the K23 to acquire knowledge, skills, and abilities necessary to the study the relationship between endocrine/neuroendocrine function and agression/impulsivity among APED users. His specific training objectives are to (a) learn the theoretical, methodological, and clinical approaches to studying the distinction between pathological and non-pathological forms of APED use, (b) develop a working knowledge of the theory and methodology available through translational research to study hormone-behavior relationships, (c) acquire expertise in the theory and methodology linking hormone dysregulation to psychiatric illness, (d) acquire greater understanding of the medical, legal, and ethical issues associated with studying substance abuse, and (e) obtain expertise in longitudinal data modeling and statistical analysis of biological data. Environment: The Pi's proposed training plan and career goals are consistent with the MSSM Department of Psychiatry's mission statement to integrate translational and clinical research, particularly in the area of neuroendocrinology. Dr. Hildebrandt has available to him a wealth of expertise and resources available including the lab facilitates necessary to study both endocrine and neuroendocrine functioning. Research: The most reliable psychiatric consequence to APED use is increased impulsive aggression although a range of psychiatric disturbances have been observed. The supervised research project will be a longitudinal study of the degree of both hormone and psychiatric dysregulation (aggression and impulsivity) in 60 adult male APED users across time (on-cycle and off-cycle) compared to 20 age, exercise, and education matched controls. Piecewise latent growth curve modeling will be used to investigate changes on-cycle and off-cycle changes and the following predictors of change will be explored: APED characteristics (amount, duration, and pattern), Age, Psychiatric History, Personality, & History of APED use). Relevance: Findings from the proposed study will help identify both the endocrine dysfunction responsible for the psychiatric consequences to APED use and the user characteristics predictive of these psychiatric consequences. Implications of this research are to inform prevention, intervention, and policy based decisions related to this growing public health concern.
拟议的K23患者导向职业发展奖旨在为PI提供

项目成果

期刊论文数量(16)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Body checking behaviors in men.
男性的身体检查行为。
  • DOI:
    10.1016/j.bodyim.2009.05.001
  • 发表时间:
    2009
  • 期刊:
  • 影响因子:
    5.2
  • 作者:
    Walker,DCatherine;Anderson,DrewA;Hildebrandt,Thomas
  • 通讯作者:
    Hildebrandt,Thomas
Conceptualizing the role of estrogens and serotonin in the development and maintenance of bulimia nervosa.
  • DOI:
    10.1016/j.cpr.2010.04.011
  • 发表时间:
    2010-08
  • 期刊:
  • 影响因子:
    12.8
  • 作者:
    Hildebrandt, Tom;Alfano, Lauren;Tricamo, Michelle;Pfaff, Donald W.
  • 通讯作者:
    Pfaff, Donald W.
Defining the Construct of Synthetic Androgen Intoxication: An Application of General Brain Arousal.
  • DOI:
    10.3389/fpsyg.2018.00390
  • 发表时间:
    2018
  • 期刊:
  • 影响因子:
    3.8
  • 作者:
    Hildebrandt T;Heywood A;Wesley D;Schulz K
  • 通讯作者:
    Schulz K
Predictors and correlates of follow-up visit adherence among adolescents receiving laparoscopic adjustable gastric banding.
Enhanced cognitive behavioural therapy for an adolescent with purging disorder: a case report.
  • DOI:
    10.1002/erv.1044
  • 发表时间:
    2011-01
  • 期刊:
  • 影响因子:
    5.3
  • 作者:
    Sysko, Robyn;Hildebrandt, Tom
  • 通讯作者:
    Hildebrandt, Tom
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THOMAS B HILDEBRANDT其他文献

THOMAS B HILDEBRANDT的其他文献

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{{ truncateString('THOMAS B HILDEBRANDT', 18)}}的其他基金

A Confirmatory Efficacy Study of Interoceptive Exposure for Adolescents with Low Weight Eating Disorders
内感受暴露对低体重饮食失调青少年的有效性研究
  • 批准号:
    10571565
  • 财政年份:
    2023
  • 资助金额:
    $ 17.7万
  • 项目类别:
General Brain Arousal and Risk for Eating Disorder
一般大脑唤醒和饮食失调的风险
  • 批准号:
    10365378
  • 财政年份:
    2021
  • 资助金额:
    $ 17.7万
  • 项目类别:
General Brain Arousal and Risk for Eating Disorder
一般大脑唤醒和饮食失调的风险
  • 批准号:
    10656518
  • 财政年份:
    2021
  • 资助金额:
    $ 17.7万
  • 项目类别:
Noom Coach for Bariatric Surgery
Noom 减肥手术教练
  • 批准号:
    9464753
  • 财政年份:
    2017
  • 资助金额:
    $ 17.7万
  • 项目类别:
Reward Systems and Food Avoidance in Adolescents with Low Weight Eating Disorders
低体重饮食失调青少年的奖励制度和食物避免
  • 批准号:
    9334942
  • 财政年份:
    2016
  • 资助金额:
    $ 17.7万
  • 项目类别:
Reward Systems and Food Avoidance in Adolescents with Low Weight Eating Disorders
低体重饮食失调青少年的奖励系统和食物避免
  • 批准号:
    10222953
  • 财政年份:
    2016
  • 资助金额:
    $ 17.7万
  • 项目类别:
Innovative Use of the Noom Monitor Mobile Application for CBT-GSH in Binge Eaters
Noom Monitor 移动应用程序在暴食者中创新地使用 CBT-GSH
  • 批准号:
    8521678
  • 财政年份:
    2013
  • 资助金额:
    $ 17.7万
  • 项目类别:
Innovative Use of the Noom Monitor Mobile Application for CBT-GSH in Binge Eaters
Noom Monitor 移动应用程序在暴食者中创新地使用 CBT-GSH
  • 批准号:
    8665495
  • 财政年份:
    2013
  • 资助金额:
    $ 17.7万
  • 项目类别:
Bio-behavioral Consequences of Appearance and Performance Enhancing Drug Use
外观和性能增强药物使用的生物行为后果
  • 批准号:
    7530230
  • 财政年份:
    2008
  • 资助金额:
    $ 17.7万
  • 项目类别:
Bio-behavioral Consequences of Appearance and Performance Enhancing Drug Use
外观和性能增强药物使用的生物行为后果
  • 批准号:
    8081856
  • 财政年份:
    2008
  • 资助金额:
    $ 17.7万
  • 项目类别:

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