Bio-behavioral Consequences of Appearance and Performance Enhancing Drug Use

拟议的K23以患者为导向的职业发展奖旨在为PI提供 研究个体差异对生物行为的影响所必需的培训， 性能增强药物（APED）的使用。候选人：PI是助理教授和有执照的临床 目前在西奈山医学院（MSSM）饮食和体重的心理学家 疾病计划。他计划使用K23成为R01资助的研究人员，与 基础和转化科学家对临床，伦理和科学的挑战，提出了使用APED。在 为了实现这些职业目标，他将使用K23获得必要的知识，技能和能力， 研究内分泌/神经内分泌功能与攻击性/冲动性之间的关系， APED用户。他的具体培训目标是（a）学习理论，方法和临床 研究病理性和非病理性形式的APED使用之间的区别的方法，（B） 通过转化研究发展理论和方法的工作知识， 研究行为与行为的关系，（c）获得有关激素的理论和方法的专业知识 （d）对精神疾病的医学、法律的和伦理的理解 与研究药物滥用相关的问题，以及（e）获得纵向数据建模方面的专业知识， 生物数据的统计分析。环境：Pi提出的培训计划和职业目标是 与MSSM精神病学系的使命声明相一致， 临床研究，特别是在神经内分泌学领域。希尔德布兰特博士有一个 丰富的专业知识和资源，包括实验室，有助于研究内分泌 和神经内分泌功能。研究：使用APED最可靠的精神后果是 冲动性攻击增加，尽管已经观察到一系列精神障碍。的 监督研究项目将是一个纵向研究的程度都激素和精神 60名成人男性APED使用者随时间（周期和周期关闭）的失调（攻击性和冲动性） 与20名年龄、锻炼和教育程度相匹配的对照组相比。分段潜在增长曲线建模将 用于调查周期内和周期外的变化，以下变化预测因素将 探索：APED特征（数量，持续时间和模式），年龄，精神病史，个性，& APED使用史）。相关性：拟议研究的结果将有助于识别内分泌 功能障碍负责精神后果的APED使用和用户的特点 这些心理后果的预测。这项研究的意义是为预防提供信息， 干预措施和基于政策的决策，与这一日益增长的公共卫生问题有关。

The proposed K23 Patient-Oriented Career Development Award is designed to provide the PI with the training necessary to study the individual variability in bio-behavioral consequences of appearance and performance enhancing drug (APED) use. Candidate: The PI is an Assistant Professor and licensed clinical Dsychologist currently working at the Mount Sinai School of Medicine's (MSSM's) Eating and Weight Disorders Program. He plans to use the K23 to become an R01 funded researcher that works closely with basic and translational scientists on the clinical, ethical, and scientific challenges presented by APED use. In order to obtain these career goals, he will use the K23 to acquire knowledge, skills, and abilities necessary to the study the relationship between endocrine/neuroendocrine function and agression/impulsivity among APED users. His specific training objectives are to (a) learn the theoretical, methodological, and clinical approaches to studying the distinction between pathological and non-pathological forms of APED use, (b) develop a working knowledge of the theory and methodology available through translational research to study hormone-behavior relationships, (c) acquire expertise in the theory and methodology linking hormone dysregulation to psychiatric illness, (d) acquire greater understanding of the medical, legal, and ethical issues associated with studying substance abuse, and (e) obtain expertise in longitudinal data modeling and statistical analysis of biological data. Environment: The Pi's proposed training plan and career goals are consistent with the MSSM Department of Psychiatry's mission statement to integrate translational and clinical research, particularly in the area of neuroendocrinology. Dr. Hildebrandt has available to him a wealth of expertise and resources available including the lab facilitates necessary to study both endocrine and neuroendocrine functioning. Research: The most reliable psychiatric consequence to APED use is increased impulsive aggression although a range of psychiatric disturbances have been observed. The supervised research project will be a longitudinal study of the degree of both hormone and psychiatric dysregulation (aggression and impulsivity) in 60 adult male APED users across time (on-cycle and off-cycle) compared to 20 age, exercise, and education matched controls. Piecewise latent growth curve modeling will be used to investigate changes on-cycle and off-cycle changes and the following predictors of change will be explored: APED characteristics (amount, duration, and pattern), Age, Psychiatric History, Personality, & History of APED use). Relevance: Findings from the proposed study will help identify both the endocrine dysfunction responsible for the psychiatric consequences to APED use and the user characteristics predictive of these psychiatric consequences. Implications of this research are to inform prevention, intervention, and policy based decisions related to this growing public health concern.