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General Brain Arousal and Risk for Eating Disorder

一般大脑唤醒和饮食失调的风险

基本信息

批准号：
10365378
负责人：
THOMAS B HILDEBRANDT
金额：
$ 43.41万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-22 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10365378
关键词：
10 year old 12 year old 13 year old Accounting Adolescence Adolescent Age Anterior Arousal Back Behavior Behavioral Binge Eating Brain Clinical Cognitive Computer Models Corpus striatum structure Cues Data Development Diagnosis Eating Behavior Eating Disorders Emotional Endocrine Ensure Environment Female Food Functional Magnetic Resonance Imaging Genetic Risk Gonadal Hormones Graph Hormonal Hormones Inferior Insula of Reil Link Locomotion Mediating Mediation Modality Modeling Motor Activity Neuraxis Neurobiology Neurosecretory Systems Ovarian hormone Positioning Attribute Property Psychological Techniques Puberty Research Rewards Risk Role Seminal Sex Differences Signal Transduction Social Environment Substance of Abuse Testing Twin Studies Validation Work boys cognitive development cohort cost critical developmental period disorder risk early adolescence emotional experience feeding financial incentive follow-up functional status girls heuristics longitudinal dataset motivated behavior prepuberty psychosocial response reward processing sensory input sex sexual dimorphism social theories

项目摘要

The prepubertal gonadal hormone surge that primes the rapid social and emotional development of adolescence has specific influences on female brains that may account for the accelerated risk for disordered eating and development of binge eating in girls relative to boys. We propose to test a model of sex differences in the risk for binge eating in early adolescence that emphasizes the differential influence of gonadal hormone status on the development of functional brain networks in girls relative to boys to account for the enhanced risk during this vulnerable period. The model leverages general brain arousal theory to predict the effect of gonadal hormones on functional brain networks, and builds on theoretical work by the MPI, seminal work by Dr. Kelly Klump and colleagues on moderated genetic risks for disordered eating in twin studies, and the pioneering work of Dr. Donald Pfaff and colleagues on the activating effects of gonadal hormones. The specific aims of this R01 project are two-fold: 1) to test for sex differences in the mediation of binge eating risk by gonadal hormonal influences on brain networks for arousal, reward processing, emotional salience, and inhibitory control at baseline and longitudinally over 2-year follow-up; and 2) to develop a computational model of general brain arousal to explain sex differences in the risk for binge eating in early adolescence. The central hypotheses are that (i) gonadal hormone status will predict the developmental status of functional brain networks for arousal, reward processing, emotional salience, and inhibitory control longitudinally in girls but not boys; (ii) these neuroendocrine interactions will mediate the risk for binge eating longitudinally in girls but not boys; and (iii) gonadal hormone status will predict covariation between these brain networks in girls but not boys, suggesting a sexually dimorphic mechanism for gonadal hormones to influence a range of behaviors characterized by altered responses to salient, rewarding, and stressful environmental cues. The large set of clinical, endocrine, and functional magnetic resonance imaging (fMRI) data collected for the Adolescent Brain Cognitive Development (ABCD) study at baseline and follow-up presents an ideal mechanism to test this model of sex differences in risk for binge eating during the critical developmental period in early puberty when gonadal hormone levels surge and maladaptive eating behaviors first emerge. These aims have direct

青春期前性腺激素的激增，使儿童的社会和情感发展迅速