General Brain Arousal and Risk for Eating Disorder

一般大脑唤醒和饮食失调的风险

基本信息

批准号：
10656518
负责人：
THOMAS B HILDEBRANDT
金额：
$ 40.12万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-22 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10656518
关键词：
10 year old 12 year old 13 year old Acceleration Accounting Adolescence Adolescent Age Anterior Arousal Back Behavior Behavioral Binge Eating Brain Central Nervous System Clinical Cognitive Computer Models Corpus striatum structure Cues Data Development Diagnosis Eating Behavior Eating Disorders Emotional Endocrine Ensure Environment Female Food Functional Magnetic Resonance Imaging Genetic Risk Gonadal Hormones Graph Hormonal Hormones Hyperphagia Inferior Insula of Reil Link Locomotion Mediating Mediation Modality Modeling Motor Activity Neurobiology Neurosecretory Systems Ovarian hormone Positioning Attribute Property Psychological Techniques Puberty Research Rewards Risk Role Seminal Sex Differences Signal Transduction Social Environment Substance of Abuse Testing Twin Studies Validation Work boys cognitive development cohort cost critical developmental period disorder risk early adolescence emotional experience feeding financial incentive follow-up functional status girls heuristics longitudinal dataset model building motivated behavior preadolescence prepuberty psychosocial response reward processing sensory input sex sexual dimorphism social theories

项目摘要

The prepubertal gonadal hormone surge that primes the rapid social and emotional development of adolescence has specific influences on female brains that may account for the accelerated risk for disordered eating and development of binge eating in girls relative to boys. We propose to test a model of sex differences in the risk for binge eating in early adolescence that emphasizes the differential influence of gonadal hormone status on the development of functional brain networks in girls relative to boys to account for the enhanced risk during this vulnerable period. The model leverages general brain arousal theory to predict the effect of gonadal hormones on functional brain networks, and builds on theoretical work by the MPI, seminal work by Dr. Kelly Klump and colleagues on moderated genetic risks for disordered eating in twin studies, and the pioneering work of Dr. Donald Pfaff and colleagues on the activating effects of gonadal hormones. The specific aims of this R01 project are two-fold: 1) to test for sex differences in the mediation of binge eating risk by gonadal hormonal influences on brain networks for arousal, reward processing, emotional salience, and inhibitory control at baseline and longitudinally over 2-year follow-up; and 2) to develop a computational model of general brain arousal to explain sex differences in the risk for binge eating in early adolescence. The central hypotheses are that (i) gonadal hormone status will predict the developmental status of functional brain networks for arousal, reward processing, emotional salience, and inhibitory control longitudinally in girls but not boys; (ii) these neuroendocrine interactions will mediate the risk for binge eating longitudinally in girls but not boys; and (iii) gonadal hormone status will predict covariation between these brain networks in girls but not boys, suggesting a sexually dimorphic mechanism for gonadal hormones to influence a range of behaviors characterized by altered responses to salient, rewarding, and stressful environmental cues. The large set of clinical, endocrine, and functional magnetic resonance imaging (fMRI) data collected for the Adolescent Brain Cognitive Development (ABCD) study at baseline and follow-up presents an ideal mechanism to test this model of sex differences in risk for binge eating during the critical developmental period in early puberty when gonadal hormone levels surge and maladaptive eating behaviors first emerge. These aims have direct

刺激的前性腺激素激素激增，刺激了快速的社会和情感发展青春期对女性大脑具有特定的影响，这可能会导致无序的加速风险相对于男孩，女孩的饮食和发展。我们建议测试性别差异模型在青春期早期暴饮暴食的风险中，强调了性腺激素的差异影响关于女孩相对于男孩的功能性脑网络发展的状态，以考虑增强的风险在这个脆弱的时期。该模型利用一般的大脑唤醒理论来预测性腺的影响功能性脑网络上的激素，并基于MPI的理论工作，凯利博士的开创性工作 Klump及其同事介绍了双胞胎研究中的遗传风险，并开创性 Donald Pfaff博士及其同事对性腺激素的激活作用的工作。该R01项目的具体目的是两个方面：1）测试在调解中的性别差异性腺激素对大脑网络的影响狂暴饮食风险，以唤醒，奖励处理，情感在基线和纵向2年的随访中，显着性和抑制性控制； 2）开发一个通用大脑唤醒的计算模型，以解释早期暴饮暴食风险的性别差异青春期。中心假设是（i）性腺激素状态将预测发育功能性大脑网络的状态，用于唤醒，奖励处理，情感显着性和抑制性控制在女孩中纵向而不是男孩；（ii）这些神经内分泌相互作用将调解暴饮暴食的风险在女孩中纵向而不是男孩；（iii）性腺激素状态将预测这些大脑之间的协方差女孩的网络，但没有男孩，提出了性腺激素的性二态机制一系列行为的特征是对显着，有益和压力紧张的环境的反应改变提示。收集的大量临床，内分泌和功能磁共振成像（fMRI）数据在基线和随访时，青春期的大脑认知发展（ABCD）研究表现为理想在关键发育时期测试这种性别差异的性别差异模型的机制在青春期初期，性腺激素水平涌动和适应不良的饮食行为首先出现。这些目标是直接的