Sex-Specific Brain and Behavioral Predictors of Cognitive Aging in Middle-Aged Adults with Autism Spectrum Disorder

患有自闭症谱系障碍的中年人认知衰老的性别特异性大脑和行为预测因子

• 批准号: 10584247
• 负责人: Brittany Blair Braden
• 金额: $ 5.4万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-06-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10584247
• 关键词: Adult; Age-associated memory impairment; Aging; Alzheimer' s Disease; Arizona; Basic Science; Behavioral; Brain; Caring; Cognitive; Cognitive aging; Data; Data Set; Development; Development Plans; Elderly; Environment; Foundations; Funding; Goals; Health; Home; Institutes; Institution; Interdisciplinary Study; International; Intervention; Least-Squares Analysis; Machine Learning; Measures; Mentors; Methods; Neurobiology; Neurosciences; Participant; Patient Care; Phenotype; Process; Research; Research Design; Research Personnel; Research Project Grants; Resources; Training; Universities; Vulnerable Populations; Woman; adult with autism spectrum disorder; age related; age related cognitive change; aging brain; autism community; autism spectrum disorder; base; behavior measurement; career; career development; cognitive neuroscience; cost; health care quality; men; middle age; multi-task learning; multidisciplinary; multimodality; neuroimaging; precision medicine; programs; sex; young adult

Project Summary/Abstract Research Project Long-Term Objective: The long-term objective of this research is to describe the cognitive challenges associated with aging in adults with ASD to inform interventions and care plans. Aim 1: Identify the combination of sex-specific functional and structural brain measures in adults with ASD that (a) best describe age-related cognitive changes compared to matched-NT controls and (b) predict age-related cognitive decline. Methods: We will use multi-modal partial least squared analysis to elucidate information linkage between complementary neuroimaging data sets. Research Design: We will analyze both cross-sectional data of young-adult (n=100) vs. middle- aged (n=120) ASD and NT groups, and longitudinal data of middle-aged adults in two year increments (n=120 participants; 360 data sets). Men and women will be similarly represented in groups (M:F ratio, 1.0 : 0.7). Aim 2: Identify the combination of behavioral measures in adults with ASD that best predict age-related cognitive decline. Methods: We will use multi-task learning to determine the linkage between complementary behavioral data sets. Research Design: We will analyze cross-sectional and longitudinal data from Aim 1 ASD participants. Health Relatedness: These aims will have a substantial positive impact on health care quality and costs in the ASD community by vertically advancing our understanding of the unique cognitive and brain aging process, and laying the groundwork for delivering effective, precision medicine care to the growing and vulnerable population of older adults with ASD. Candidate Career Goals: Dr. Braden's long-term goal is to become a leading researcher in the neurobiology of aging in ASD through a multi-disciplinary program from basic science to translational treatment. Her short-term goals are to: 1) comprehensively describe age-related cognitive and brain changes in adults with ASD, and 2) identify targets for behavioral and neurobiological interventions and care plans tailored to specific cognitive needs of older adults with ASD. Career Development Plan: Building on her strong foundation in multi-disciplinary cognitive aging neuroscience, Dr. Braden will have intensive training in: 1) advanced neuroimaging analytics, 2) ASD phenotyping and interventions, and 3) professional and programmatic development for leading a funded multi-disciplinary research effort. Environment: Each training aim has an expert mentor across three local institutions with abundant academic overlap. Dr. Braden's home institution, Arizona State University, is one of the fastest growing research enterprise among all U.S. universities, and specializes in the neuroscience of cognitive and brain aging. She will also receive training at the Banner Alzheimer's Institute, an internationally recognized research and patient care program, and the Southwest Autism Research and Resource Center, an ASD community-based center of excellence.

项目摘要/摘要 研究项目长期目标：本研究的长期目标是描述认知挑战 与成人自闭症患者的老龄化相关，为干预和护理计划提供信息。 目标1：确定成人自闭症患者的性别特异性脑功能和结构测量的组合：(A)最佳 描述与配对NT对照相比与年龄相关的认知变化，并(B)预测与年龄相关的认知衰退。 方法：我们将使用多峰偏最小二乘分析来阐明互补之间的信息联系 神经成像数据集。研究设计：我们将分析青壮年(n=100)和中青年(n=100)的横断面数据。 老年组(n=120)ASD和NT组，以及两年递增的中年人纵向数据(n=120 参与者；360个数据集)。男性和女性将以同样的比例分组(男女比例为1.0：0.7)。 目标2：确定成人自闭症患者的行为测量组合最能预测与年龄相关的认知 拒绝。方法：我们将使用多任务学习来确定互补行为数据集之间的联系。 研究设计：我们将分析目标1自闭症患者的横断面和纵向数据。 与健康相关：这些目标将对ASD的医疗质量和成本产生实质性的积极影响 社区通过垂直推进我们对独特的认知和大脑老化过程的理解，并奠定 为不断增长的老年弱势群体提供有效、精准的医疗保健的基础工作 患有自闭症。 候选人的职业目标：布拉登博士的长期目标是成为美国衰老神经生物学领域的领军人物 通过从基础科学到转化性治疗的多学科计划。她的短期目标是：1) 全面描述成人自闭症患者与年龄相关的认知和大脑变化，以及2)确定目标 针对患有自闭症的老年人的特定认知需求量身定做的行为和神经生物学干预和护理计划。 职业发展计划：在多学科认知衰老神经科学的坚实基础上，Dr。 Braden将接受以下方面的强化培训：1)高级神经成像分析，2)ASD表型和干预，以及 3)领导资助的多学科研究工作的专业性和程序性发展。 环境：每个培训目标都有一名专家导师，来自三个学术重叠较多的地方机构。Dr。 布拉登的母校亚利桑那州立大学是美国发展最快的研究机构之一。 大学，专门研究认知和大脑老化的神经科学。她还将在Banner接受培训 阿尔茨海默氏症研究所，一个国际公认的研究和患者护理项目，以及西南自闭症 研究和资源中心，一个以ASD社区为基础的卓越中心。

项目成果

Brain-based sex differences in autism spectrum disorder across the lifespan: A systematic review of structural MRI, fMRI, and DTI findings.

• DOI: 10.1016/j.nicl.2021.102719
• 发表时间: 2021
• 期刊: NeuroImage. Clinical
• 作者: Walsh MJM;Wallace GL;Gallegos SM;Braden BB
• 通讯作者: Braden BB

Effects of age on the hippocampus and verbal memory in adults with autism spectrum disorder: Longitudinal versus cross-sectional findings.

• DOI: 10.1002/aur.2797
• 发表时间: 2022-10
• 期刊: AUTISM RESEARCH
• 影响因子: 4.7
• 作者: Pagni, Broc A.;Walsh, Melissa J. M.;Ofori, Edward;Chen, Kewei;Sullivan, Georgia;Alvar, Jocelyn;Monahan, Leanna;Guerithault, Nicolas;Delaney, Shanna;Braden, B. Blair
• 通讯作者: Braden, B. Blair

Quality of life in adults with autism spectrum disorder: influence of age, sex, and a controlled, randomized mindfulness-based stress reduction pilot intervention.

• DOI: 10.1007/s11136-021-03013-x
• 发表时间: 2022-05
• 期刊: QUALITY OF LIFE RESEARCH
• 影响因子: 3.5
• 作者: Braden, B. Blair;Pagni, Broc A.;Monahan, Leanna;Walsh, Melissa J. M.;Dixon, Maria, V;Delaney, Shanna;Ballard, Lisa;Ware, John E., Jr.
• 通讯作者: Ware, John E., Jr.

APOE ε4-Allele in Middle-Aged and Older Autistic Adults: Associations with Verbal Learning and Memory.

• DOI: 10.3390/ijms242115988
• 发表时间: 2023-11-05
• 期刊: International journal of molecular sciences
• 影响因子: 5.6

Sex-related brain connectivity correlates of compensation in adults with autism: insights into female protection.

与性别相关的大脑连接与成年自闭症患者的补偿相关：对女性保护的见解。

• DOI: 10.1093/cercor/bhac069
• 发表时间: 2022
• 期刊: Cerebral cortex (New York, N.Y. : 1991)
• 作者: Walsh,MelissaJM;Pagni,Broc;Monahan,Leanna;Delaney,Shanna;Smith,ChristopherJ;Baxter,Leslie;Braden,BBlair
• 通讯作者: Braden,BBlair