Surface-Based Fiber Tracking and Modeling Techniques for Mapping the Superficial White Matter Connectome with Diffusion MRI

基于表面的纤维跟踪和建模技术,用于利用扩散 MRI 绘制浅表白质连接组图

基本信息

  • 批准号:
    10588001
  • 负责人:
  • 金额:
    $ 56.28万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-09-22 至 2027-01-31
  • 项目状态:
    未结题

项目摘要

Abstract The superficial white matter (SWM) lies directly beneath the cortex and contains the short association fibers, or U-fibers, connecting neighboring gyri. The SWM contains around twice as many fiber connections as the deep white matter (DWM) and plays a crucial role in brain development, aging, and various brain disorders. Existing connectome imaging research based on diffusion MRI (dMRI), however, mostly focuses on the connections of long fiber bundles in the DWM even though tremendous advances have been made in human connectome imaging with much improved spatial and angular resolution. In this proposed renewal of our R01 project (NIBIB R01EB022744), we will conduct systematic development of novel computational tools to fill major technical gaps in current SWM research. Our project will provide fundamentally novel solutions to many of the current challenges in SWM connectome research by developing surface-based tools for fiber tracking, atlas construction, and personalized analysis. We will also develop novel personalized dMRI harmonization methods with a particular focus on accounting for the variable cortical anatomy. These developments will for the first time provide dedicated tools for modeling SWM connectome with greatly improved robustness and accuracy. There are three specific aims in our project: 1. Development of novel surface-based fiber tracking and filtering algorithms for the modeling of superficial white matter connectivity. 2. Development of surface-based U-fiber atlases and personalized SWM connectivity analysis. 3. Development of personalized diffusion MRI harmonization tools with improved consistency in cortical anatomy. Rigorous validations of our novel surface-based U-fiber tracking and modeling methods will be performed on high-resolution MRI of post-mortem brains, in vivo intracranial neural recordings from surgically implanted electrodes in patients with epilepsy, and their application in multiple large- scale connectome imaging datasets (n>5000). All software tools and atlases developed in this project will be publicly shared, which will allow brain imaging researchers to augment their current connectome models with U- fibers in SWM and more completely map human brain connectomes for the detection of their alterations in various brain disorders.
摘要

项目成果

期刊论文数量(0)
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会议论文数量(0)
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Yonggang Shi其他文献

Yonggang Shi的其他文献

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{{ truncateString('Yonggang Shi', 18)}}的其他基金

Shape-based personalized AT(N) imaging markers of Alzheimer's disease
基于形状的个性化阿尔茨海默病 AT(N) 成像标记
  • 批准号:
    10667903
  • 财政年份:
    2023
  • 资助金额:
    $ 56.28万
  • 项目类别:
Tau-induced connectome imaging markers of Alzheimer's disease
Tau 诱导的阿尔茨海默病连接组成像标志物
  • 批准号:
    10062748
  • 财政年份:
    2020
  • 资助金额:
    $ 56.28万
  • 项目类别:
Brainstem connectomes related to Alzheimer's disease
与阿尔茨海默病相关的脑干连接体
  • 批准号:
    9524584
  • 财政年份:
    2018
  • 资助金额:
    $ 56.28万
  • 项目类别:
Project: TR&D 3 (Intrinsic Shape Analysis)
项目:TR
  • 批准号:
    9480330
  • 财政年份:
    2016
  • 资助金额:
    $ 56.28万
  • 项目类别:
Computational Tools for Modeling Human and Mouse Connectome with Multi-Shell Diffusion Imaging
利用多壳扩散成像对人类和小鼠连接组进行建模的计算工具
  • 批准号:
    9768460
  • 财政年份:
    2016
  • 资助金额:
    $ 56.28万
  • 项目类别:
Computational Tools for Modeling Human and Mouse Connectome with Multi-Shell Diffusion Imaging
利用多壳扩散成像对人类和小鼠连接组进行建模的计算工具
  • 批准号:
    9356511
  • 财政年份:
    2016
  • 资助金额:
    $ 56.28万
  • 项目类别:
Intrinsic Modeling and Tracking of Neuroanatomy in Alzheimer's Disease
阿尔茨海默病神经解剖学的内在建模和跟踪
  • 批准号:
    8646917
  • 财政年份:
    2012
  • 资助金额:
    $ 56.28万
  • 项目类别:
Intrinsic Modeling and Tracking of Neuroanatomy in Alzheimer's Disease
阿尔茨海默病神经解剖学的内在建模和跟踪
  • 批准号:
    8164121
  • 财政年份:
    2012
  • 资助金额:
    $ 56.28万
  • 项目类别:
Intrinsic Modeling and Tracking of Neuroanatomy in Alzheimer's Disease
阿尔茨海默病神经解剖学的内在建模和跟踪
  • 批准号:
    8758885
  • 财政年份:
    2012
  • 资助金额:
    $ 56.28万
  • 项目类别:
Intrinsic Modeling and Tracking of Neuroanatomy in Alzheimer's Disease
阿尔茨海默病神经解剖学的内在建模和跟踪
  • 批准号:
    9039077
  • 财政年份:
    2012
  • 资助金额:
    $ 56.28万
  • 项目类别:

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