Genomic Instability and DNA Repair

基因组不稳定性和 DNA 修复

• 批准号: 10608878
• 负责人: TERRY L. SHEPPARD
• 金额: $ 1.5万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-28 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10608878
• 关键词: Acceleration; Affect; Antineoplastic Agents; Area; Attention; Biology; COVID-19 pandemic; Canada; Cell division; Cell physiology; Chromatin; Clinic; Collaborations; Communication; DNA Repair; DNA biosynthesis; Development; Disease; Educational workshop; Fertilization; Genome Stability; Genome engineering; Genomic DNA; Genomic Instability; Immune signaling; Inflammatory; International; Knowledge; Learning; Malignant Neoplasms; Medical; Methodology; Molecular; Nuclear; Outcome; Physiological; Poly(ADP-ribose) Polymerase Inhibitor; Process; Public Health; Reaction; Research; Research Personnel; Science; Scientist; Signal Transduction; Students; Underrepresented Minority; Vacuum; Virus Diseases; Woman; Work; acute stress; cancer immunotherapy; clinical practice; disorder control; human disease; improved; next generation; novel therapeutic intervention; pandemic disease; posters; programs; single molecule; small molecule inhibitor; symposium; targeted agent; treatment strategy

ABSTRACT Support is requested for a Keystone Symposia conference entitled Genomic Instability and DNA Repair, organized by Drs. Katharina Schlacher, Irene Chiolo and Ralph Scully. The conference will be held in Whistler, BC, Canada from March 19-23, 2023. DNA replication and repair are critical processes that initiate, orchestrate, and affect a broad range of fundamental physiological reactions, ultimately promoting cell division, genome stability, and proper cellular physiology. The field of genome stability is rich in mechanistic understanding that directly led to development of small molecule inhibitors such as PARP inhibitors, now used standardly in the clinic as anti-cancer agents. Nuclear genome stability actors, however, do not act in a vacuum, but interact, communicate and collaborate with diverse intrinsic and extrinsic cellular processes. The field is at the cusp of the next level of understanding of how diverse cellular and physiological reactions directly work together with genome stability mechanisms on a molecular level and how to use this understanding to develop new treatment strategies against human diseases. The control and governance of inflammatory and immune signaling reactions as it relates to replication and chromatin reactions in particular is a potentially potent cutting-edge connection for the field, given the importance of these reactions during immunotherapy of cancer. This is enabled specifically by the continued development of single molecule targeting agents, which have arise from the strong molecular understanding of the field. The knowledge of how to control and direct inflammatory signaling will propel our understanding of how to control diseases beyond cancer. This includes viral infections, which are of particular relevance to public health during the recent pandemic. This Keystone Symposia conference will highlight the latest advances and emerging concepts in the field, aspiring to prompt rich discussions especially focused on implications for medical biology, disease and treatment strategies. This conference focusing on DNA replication and repair will be held jointly with a conference on Precision Genome Engineering, providing outstanding opportunities for cross-fertilization between these two complementary fields.

摘要 请求为题为基因组不稳定和DNA修复的Keystone研讨会提供支持， 由凯瑟琳娜·施拉赫博士、艾琳·乔洛和拉尔夫·斯库利博士组织。会议将在惠斯勒举行， 加拿大公元前，2023年3月19日至23日。 DNA复制和修复是启动、协调和影响广泛的 基本的生理反应，最终促进细胞分裂、基因组稳定和正常的细胞 生理学。基因组稳定性领域有丰富的机制理解，直接导致了发展 小分子抑制剂，如PARP抑制剂，现在作为抗癌药物在临床上标准使用 探员们。然而，核基因组稳定行动者并不是在真空中行动，而是相互作用、交流和 通过不同的内在和外在细胞过程进行协作。这个领域正处于下一阶段的尖端 理解不同的细胞和生理反应如何直接与基因组稳定性一起工作 分子水平上的机制以及如何利用这一认识开发新的治疗策略 对抗人类疾病。炎症和免疫信号反应的控制和控制 与复制和染色质反应有关，尤其是染色质反应，是一种潜在的、强有力的前沿连接 鉴于这些反应在癌症免疫治疗中的重要性。这是专门通过以下方式启用的 单分子靶向剂的不断发展，这些靶向剂是由强分子 对该领域的理解。关于如何控制和引导炎症信号的知识将推动我们的 了解如何控制癌症以外的疾病。这包括病毒感染，这是特别的 在最近的大流行期间对公共卫生的相关性。本次Keystone研讨会将突出 该领域的最新进展和新兴概念，渴望引发特别关注的丰富讨论 对医学生物学、疾病和治疗策略的影响。这次会议的焦点是DNA 复制和修复将与精密基因组工程会议联合举行，提供 这两个互补领域之间的交叉受精的绝佳机会。