Precision Genome Engineering

精准基因组工程

• 批准号: 10608865
• 负责人: TERRY L. SHEPPARD
• 金额: $ 2.1万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10608865
• 关键词: Academia; Acceleration; Address; Agriculture; Animals; Authorization documentation; Biochemistry; Biology; Canada; Cell Therapy; Cellular biology; Clinic; Clinical Data; Collaborations; DNA; DNA Repair; Data; Development; Disease; Educational workshop; Environment; Enzymes; Ethicists; Ethics; Genes; Genetic Engineering; Genome; Genome engineering; Genomic DNA; Genomic Instability; Genomics; Health; Human; Industrialization; Investments; Joints; Knowledge; Learning; Livestock; Malignant Neoplasms; Medicine; Methodology; Nuclear Receptors; Outcome; Participant; Pathology; Plants; Research; Research Personnel; Risk; Safety; Science; Scientist; Specificity; System; Technology; Therapeutic; Translations; Work; authority; career development; clinical practice; design; drug candidate; epigenomics; genome editing; genotoxicity; improved; in vivo; interest; lectures; next generation; novel; posters; pre-clinical; programs; symposium; therapeutic development; tool; tool development; transcriptomics

ABSTRACT Support is requested for a Keystone Symposia conference entitled Precision Genome Engineering, organized by Drs. Laura Sepp-Lorenzino and Matthew Porteus. The conference will be held in Whistler, BC, Canada from March 19-23, 2023. Genome editing is a powerful and precise tool to change the sequence of cellular DNA for both better elucidating disease mechanisms and for developing new treatments to address underlying pathologies at the genomic, epigenomic and transcriptomic level. The basic understanding of how genome editing works, the development of new tools in genome editing, and the translation to clinic are evolving at a rapid pace. Likewise, gene editing is revolutionizing biology and therapeutics. An ever-expanding toolbox of editing enzymes and delivery solutions enable the precise manipulation of the genome, and it is fueling a diverse pipeline of applications in cell biology, plant and animal science and human therapeutics. Emerging clinical data from gene edited cell therapies along with preclinical data from in vivo delivered gene editing drug candidates are demonstrating the feasibility, versatility, and potential for efficacy and safety in humans. Furthermore, there is great interest and investment into gene editing for crops and livestock. Therefore, this Keystone Symposia conference will cover key aspects of the genome editing field, from fundamental biochemistry to tool development, to applications in biology, agriculture, and medicine. The conference will be of interest to scientists from both academia and biopharma, including regulators and ethicists. Moreover, this conference will also uniquely bring together scientists who have studied natural genome editing systems and natural DNA damage repair with scientists trying to develop novel genome editing systems through the juxtaposition of a conference focused on Genomic Instability and DNA Repair. These joint conferences will share two dual keynote lectures and two plenary sessions: Genome Instability and Cancer and Genome Editing and DNA Repair. Participants will also share mealtimes and poster sessions to enhance networking opportunities. In addition, this conference program includes a Career Development Workshop and features a panel discussion on Genome Editing Ethics. The program was also designed to provide ample opportunities for junior participates to be selected for workshop presentations as well as short talks during plenary sessions.

抽象的 请求支持Keystone研讨会会议，名为Precision Genome Engineering，有组织 由Drs。 Laura Sepp-Lorenzino和Matthew Porteus。会议将在加拿大卑诗省惠斯勒举行 从2023年3月19日至23日。 基因组编辑是改变细胞DNA序列的强大而精确的工具 阐明疾病机制和开发新的治疗方法，以解决 基因组，表观基因组和转录组水平。对基因组编辑如何工作的基本理解， 开发基因组编辑中的新工具以及对诊所的翻译正在以快速发展。 同样，基因编辑正在彻底改变生物学和治疗学。编辑的不断扩展的工具箱 酶和递送解决方案可以精确地操纵基因组，并且正在助长多样 细胞生物学，动植物科学与人类治疗学中应用中应用的管道。新兴临床 来自基因编辑的细胞疗法的数据以及体内递送的基因编辑药物的临床前数据 候选人证明了人类有效性和安全性的可行性，多功能性以及潜力。 此外，对农作物和牲畜的基因编辑具有极大的兴趣和投资。因此，这个 Keystone研讨会会议将涵盖基因组编辑领域的关键方面，从基本 工具开发的生物化学，对生物学，农业和医学的应用。会议将是 来自学术界和生物制药的科学家感兴趣，包括监管者和伦理学家。而且，这 会议还将唯一地将研究自然基因组编辑系统的科学家汇集在一起 自然DNA损伤修复，科学家试图通过 会议的并置，重点是基因组不稳定性和DNA修复。这些联合会议将 共享两个双重主题演讲和两个全体会议：基因组不稳定性和癌症和基因组 编辑和DNA修复。参与者还将分享进餐时间和海报会议，以增强网络 机会。此外，该会议计划还包括一个职业发展研讨会，并具有 小组讨论有关基因组编辑伦理的讨论。该计划还旨在提供足够的机会 为了让初级参加研讨会演讲以及全体会议期间的简短演讲。