Molecular Basis of Healthy Aging

摘要 要求为题为“健康老龄化的分子基础”的基石专题讨论会提供支助， 由艾米·韦杰斯、扫罗·维勒达和萨尔瓦多·阿斯纳尔·贝尼塔博士组织。会议将于 布雷肯里奇，科罗拉多，2023年3月26日至29日。 本次会议将探讨调节衰老轨迹的生物学机制， 有机体的恢复力该计划将包括讨论从多个研究中吸取的经验教训， 器官系统，生物体和实验模型系统，范围广泛，从分子到 系统方法。重点将放在最近的技术和概念创新， 这些转化机会为在老龄化过程中保护健康的努力开辟了新的领域。其他 重点的主题将包括讨论可能由于压力而引起的加速老化的轨迹， 疾病，遗传，表观遗传和外部（睡眠，营养，光和其他污染）的影响，以及 利用这些机制的新兴治疗机会，包括基因疗法，衰老清除剂， 衰老和免疫调节药物以及细胞替代疗法。这其中的一个独特之处是 该计划将包括采用“大数据”和机器学习方法的专家演讲者， 老化轨迹和生物标志物的荟萃分析。最后，本次会议将与 线粒体功能障碍：从超罕见疾病到衰老，这将解决围绕 线粒体的发病机制，并带来了这些关键细胞器的功能跨强大的观点 一个发展、成长和衰老的连续体。预计这些相互作用将推动令人兴奋的交叉- 从罕见的遗传性疾病和更常见的遗传性疾病中吸取经验教训和机制， 老年疾病。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Molecular Basis of Healthy Aging, organized by Drs. Amy Wagers, Saul Villeda and Salvador Aznar Benitah. The conference will be held in Breckenridge, Colorado from March 26-29, 2023. This conference will explore the biological mechanisms that regulate trajectories of aging and enhance organismal resilience. The program will include discussions on lessons learned from research on multiple organ systems, organisms, and experimental model systems, with a broad scope spanning molecular to systems approaches. Emphasis will be placed on recent technological and conceptual innovations and translational opportunities that have opened new frontiers in the effort to protect health during aging. Other topics of focus will include discussion of the accelerated trajectories of aging that may arise due to stress, disease, genetic, epigenetic and external (sleep, nutrition, light and other pollution) influences, as well as emerging therapeutic opportunities that exploit these mechanisms, including gene therapies, senolytic, senomorphic and immune modulating drugs, and cellular replacement therapies. One unique feature of this program will be the inclusion of expert speakers employing “big data” and machine learning approaches for meta-analyses of aging trajectories and biomarkers. Finally, this conference will be held jointly with Mitochondrial Dysfunction: From Ultra-rare Diseases to Aging, which will address key questions surrounding mitochondrial pathogenesis and bring a powerful perspective on the function of these critical organelles across a continuum of development, growth and aging. It is anticipated these interactions will drive exciting cross- fertilization of ideas drawing lessons and mechanisms from both rare genetic disorders and more common diseases of advancing age.