Molecular Basis of Healthy Aging

健康老龄化的分子基础

• 批准号: 10608893
• 负责人: TERRY L. SHEPPARD
• 金额: $ 1.86万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-12-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10608893
• 关键词: Academia; Acceleration; Aging; Atmosphere; Big Data; Bioenergetics; Biological; Biological Markers; Biological Models; Biological Sciences; Biology; Biology of Aging; Cells; Colorado; Data; Development; Disease; Educational workshop; Elderly; Environment; Epigenetic Process; Experimental Models; Feedback; Fertilization; Functional disorder; Genetic; Genomics; Geroscience; Growth; Health protection; Industry; Investigation; Knowledge; Learning; Light; Machine Learning; Mentorship; Meta-Analysis; Mitochondria; Molecular; Organelles; Organism; Outcome; Participant; Pathogenesis; Pathway interactions; Pollution; Rare Diseases; Regenerative Medicine; Replacement Therapy; Research; Research Personnel; Scientist; Sleep; Speed; Stress; System; Technology; Therapeutic; body system; career; career development; clinical implementation; frontier; gene therapy; healthy aging; immune modulating agents; innovation; interdisciplinary collaboration; interest; mitochondrial dysfunction; novel; nutrition; peer; programs; rare genetic disorder; resilience; stem cell biology; symposium; synergism; translational potential

ABSTRACT Support is requested for a Keystone Symposia conference entitled Molecular Basis of Healthy Aging, organized by Drs. Amy Wagers, Saul Villeda and Salvador Aznar Benitah. The conference will be held in Breckenridge, Colorado from March 26-29, 2023. This conference will explore the biological mechanisms that regulate trajectories of aging and enhance organismal resilience. The program will include discussions on lessons learned from research on multiple organ systems, organisms, and experimental model systems, with a broad scope spanning molecular to systems approaches. Emphasis will be placed on recent technological and conceptual innovations and translational opportunities that have opened new frontiers in the effort to protect health during aging. Other topics of focus will include discussion of the accelerated trajectories of aging that may arise due to stress, disease, genetic, epigenetic and external (sleep, nutrition, light and other pollution) influences, as well as emerging therapeutic opportunities that exploit these mechanisms, including gene therapies, senolytic, senomorphic and immune modulating drugs, and cellular replacement therapies. One unique feature of this program will be the inclusion of expert speakers employing “big data” and machine learning approaches for meta-analyses of aging trajectories and biomarkers. Finally, this conference will be held jointly with Mitochondrial Dysfunction: From Ultra-rare Diseases to Aging, which will address key questions surrounding mitochondrial pathogenesis and bring a powerful perspective on the function of these critical organelles across a continuum of development, growth and aging. It is anticipated these interactions will drive exciting cross- fertilization of ideas drawing lessons and mechanisms from both rare genetic disorders and more common diseases of advancing age.

抽象的 请求支持Keystone研讨会会议，标题为“健康衰老的分子基础”， 由Drs组织。艾米·瓦格斯（Amy Wagers），索尔·比利达（Saul Villeda）和萨尔瓦多·阿兹纳（Salvador Aznar Benitah）。会议将在 2023年3月26日至29日，科罗拉多州布雷肯里奇。 这次会议将探讨调节衰老轨迹和增强轨迹的生物学机制 有机弹性。该计划将包括有关从多个研究中学到的经验教训的讨论 有机体，生物和实验模型系统，具有较大的范围跨越分子 系统方法。重点将放在最近的技术和概念创新以及 转化机会为保护衰老期间的健康开辟了新的边界。其他 重点主题将包括讨论由于压力而引起的衰老加速轨迹， 疾病，遗传，表观遗传和外部（睡眠，营养，光和其他污染）以及 利用这些机制的新兴理论机会，包括基因疗法，鼻溶剂， 鼻型和免疫调节药物以及细胞置换疗法。一个独特的功能 计划将包括使用“大数据”和机器学习方法的专家演讲者 衰老轨迹和生物标志物的荟萃分析。最后，这次会议将与 线粒体功能障碍：从超稀有疾病到衰老，这将解决有关的关键问题 线粒体的发病机理，对这些关键细胞器的功能具有强大的观点 发展，增长和衰老的连续性。预计这些互动将推动令人兴奋的交叉 - 绘画课程的施肥和罕见遗传疾病和更常见的机制 促进年龄的疾病。