Molecular Basis of Healthy Aging

摘要 请求支持Keystone研讨会，题为健康老龄化的分子基础， 由艾米·韦杰斯博士、索尔·维尔达和萨尔瓦多·阿兹纳尔·贝尼塔组织。会议将在#年举行 2023年3月26日至29日，科罗拉多州布雷肯里奇。 这次会议将探讨调节衰老轨迹和增强 生物的复原力。该计划将包括讨论从多项研究中吸取的经验教训 器官系统、生物体和实验模型系统，范围广泛，跨越分子到 系统方法。重点将放在最近的技术和概念创新以及 在努力保护老龄化期间的健康方面开辟了新的领域的翻译机会。其他 重点讨论的主题将包括讨论由于压力而可能出现的加速衰老轨迹， 疾病、遗传、表观遗传和外部(睡眠、营养、光线和其他污染)影响，以及 利用这些机制的新出现的治疗机会，包括基因治疗、抗衰老、 感觉剂和免疫调节剂，以及细胞替代疗法。它的一个独特之处就是 该计划将包括使用大数据和机器学习方法的专家演讲者 衰老轨迹和生物标记物的荟萃分析。最后，本次大会将与 线粒体功能障碍：从超罕见疾病到衰老，这将解决围绕 线粒体的发病机制，并为这些关键细胞器的功能提供了一个强有力的视角 发展、成长和衰老的连续统一体。预计这些互动将推动令人兴奋的交叉 从罕见的遗传性疾病和更常见的遗传性疾病中吸取教训和机制的思想 老年疾病。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Molecular Basis of Healthy Aging, organized by Drs. Amy Wagers, Saul Villeda and Salvador Aznar Benitah. The conference will be held in Breckenridge, Colorado from March 26-29, 2023. This conference will explore the biological mechanisms that regulate trajectories of aging and enhance organismal resilience. The program will include discussions on lessons learned from research on multiple organ systems, organisms, and experimental model systems, with a broad scope spanning molecular to systems approaches. Emphasis will be placed on recent technological and conceptual innovations and translational opportunities that have opened new frontiers in the effort to protect health during aging. Other topics of focus will include discussion of the accelerated trajectories of aging that may arise due to stress, disease, genetic, epigenetic and external (sleep, nutrition, light and other pollution) influences, as well as emerging therapeutic opportunities that exploit these mechanisms, including gene therapies, senolytic, senomorphic and immune modulating drugs, and cellular replacement therapies. One unique feature of this program will be the inclusion of expert speakers employing “big data” and machine learning approaches for meta-analyses of aging trajectories and biomarkers. Finally, this conference will be held jointly with Mitochondrial Dysfunction: From Ultra-rare Diseases to Aging, which will address key questions surrounding mitochondrial pathogenesis and bring a powerful perspective on the function of these critical organelles across a continuum of development, growth and aging. It is anticipated these interactions will drive exciting cross- fertilization of ideas drawing lessons and mechanisms from both rare genetic disorders and more common diseases of advancing age.