Learning, Memory, and Plasticity (LaMP) Training Program

学习、记忆和可塑性 (LaMP) 培训计划

• 批准号: 10614615
• 负责人: A Kimberley McAllister
• 金额: $ 25.86万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10614615
• 关键词: Learning; Memory; Training Programs

Project Summary/Abstract. This is the first renewal application for our advanced predoctoral Training Program in Learning, Memory, and Plasticity (LaMP) at UC Davis. LaMP research at UC Davis is both broad and deep, spanning 6 schools and colleges and all of the major levels of research—cognitive, systems, cellular/molecular, and disease. The 48 Trainers selected from this community are highly collaborative and value interdisciplinary approaches to their research. Our innovative Program trains the next generation of neuroscientists to bridge the gaps between the major levels of LaMP research—cognitive, systems, cellular/molecular—in order to promote our understanding of LaMP disorders and reduce their tremendous burden on families, society, and public health. This renewal application for our 4-year-old program proposes to continue to support 6 advanced predoctoral Trainees per year, a size essential for creating a group that crosses traditional disciplinary boundaries, spans levels of analysis, and addresses both basic and translational research. Trainees from 8 participating graduate groups will be eligible to apply to the LaMP Training Program in Years 2 and 3 of their graduate training. The 1-year Training Program has 6 components. (1) Trainees will conduct research in at least one of the LaMP faculty labs and will be co-mentored by another trainer from a distinct area of LaMP research. (2a) Trainees will be exposed to the essential and emerging concepts in each of the fields of LaMP through a 2-quarter core course consisting of interactive lectures as well as lab-based immersion to give trainees the tools to understand the pros and cons of both the concepts and methods used at each level of analysis. Methods to enhance reproducibility will be addressed in every session. (2b) Trainees will also be exposed to LaMP disorders through a course consisting of didactic and interview/video sessions that span clinical, cognitive, systems and molecular aspects of each disease. (3) Trainees will receive targeted career development training through a weekly meeting with the Program Directors—emphasizing critical and cross-disciplinary thinking, presentation skills, formal discussion of research-related careers outside of academia, and pressing issues in the field such as data analysis, ethics, and reproducibility. (4) Trainees will receive extensive training in grant writing prior to submission of their NRSA or equivalent. (5) Trainees and Trainers will participate in a monthly meeting to bring the community together around networking opportunities within the NeuroCareer Pathways program as well as invited experts in the field. (6) Trainees will participate in an annual program retreat and attend an invited LaMP speaker series. Our Program also emphasizes participation in outreach and diversity, equity, and inclusion programs and workshops. Through these elements, this advanced Training Program will produce a new, highly diverse generation of scientists who truly think across levels and scales and who have the skills, drive, and motivation to work collaboratively to tackle the most important issues in learning, memory, and plasticity in order to improve human health.

项目概要/摘要。 这是我们在学习，记忆和学习方面的高级博士前培训计划的第一次更新申请。 塑性（LaMP）在加州大学戴维斯分校。加州大学戴维斯分校的LaMP研究既广泛又深入，跨越6所学校， 大学和所有主要层次的研究-认知，系统，细胞/分子和疾病。的48 从这个社区中选出的培训师具有高度的协作性，并重视跨学科的方法， research.我们的创新计划培养下一代神经科学家，以弥合 LAMP研究的主要水平-认知，系统，细胞/分子-以促进我们的理解 这是一个有效的预防和治疗LaMP疾病的方法，并减轻其对家庭，社会和公共卫生的巨大负担。此续订 申请我们的4岁的计划建议继续支持6个先进的博士前学员，每 一年的时间，对于创建一个跨越传统学科界限的团队来说是必不可少的，跨越了 分析，并解决基础和转化研究。来自8个参与研究生团体的学员 将有资格申请在他们的研究生培训的第2年和第3年的LaMP培训计划。1年 培训计划有6个组成部分。(1)学员将在至少一个LaMP教师进行研究 实验室，并将由另一位来自LaMP研究不同领域的培训师共同指导。(2a)学员将 通过2个季度的核心课程，接触到LaMP每个领域的基本和新兴概念 包括互动讲座以及基于实验室的沉浸，为学员提供了解 每一级分析所用概念和方法的利弊。方法提高 每次会议都将讨论再现性问题。(2b)受训者还将接触LaMP疾病 通过由教学和访谈/视频会议组成的课程，涵盖临床，认知，系统和 每种疾病的分子特征。(3)学员将通过一个 每周与项目主管举行会议，强调批判性和跨学科思维， 技能，学术界以外的研究相关职业的正式讨论，以及该领域的紧迫问题，如 数据分析，伦理，和可重复性。(4)受训人员将接受广泛的培训，在赠款写作之前， 提交NRSA或同等文件。(5)学员和培训师将参加每月会议， 社区围绕神经职业途径计划中的网络机会，以及 邀请了该领域的专家。(6)学员将参加年度计划务虚会，并参加邀请 LaMP音箱系列。我们的计划还强调参与外展和多样性，公平， 包容方案和讲习班。通过这些元素，这个高级培训计划将产生一个 新的，高度多样化的一代科学家，他们真正跨层次和规模思考，他们有技能， 驱动力和动力，以协同工作，以解决学习，记忆和 可塑性，以改善人类健康。

项目成果

High-Frequency Stimulation of Ventral CA1 Neurons Reduces Amygdala Activity and Inhibits Fear.

• DOI: 10.3389/fnbeh.2021.595049
• 发表时间: 2021
• 期刊: Frontiers in behavioral neuroscience
• 影响因子: 3
• 作者: Graham J;D'Ambra AF;Jung SJ;Teratani-Ota Y;Vishwakarma N;Venkatesh R;Parigi A;Antzoulatos EG;Fioravante D;Wiltgen BJ
• 通讯作者: Wiltgen BJ

The iNs and Outs of Direct Reprogramming to Induced Neurons.

• DOI: 10.3389/fgeed.2020.00007
• 发表时间: 2020
• 期刊: Frontiers in genome editing
• 作者: Carter JL;Halmai JANM;Fink KD
• 通讯作者: Fink KD

How Sequential Interactive Processing Within Frontostriatal Loops Supports a Continuum of Habitual to Controlled Processing.

额纹状体环内的顺序交互处理如何支持习惯性受控处理的连续体。

• DOI: 10.3389/fpsyg.2020.00380
• 发表时间: 2020
• 期刊: Frontiers in psychology
• 影响因子: 3.8
• 作者: O'Reilly,RandallC;Nair,Ananta;Russin,JacobL;Herd,SethA
• 通讯作者: Herd,SethA

Regulation of the Ca2+ Channel CaV1.2 Supports Spatial Memory and Its Flexibility and LTD.

Ca2 通道 CaV1.2 的调节支持空间记忆及其灵活性和 LTD。

• DOI: 10.1523/jneurosci.1521-22.2023
• 发表时间: 2023
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Ireton,KyleE;Xing,Xiaoming;Kim,Karam;Weiner,JustinC;Jacobi,ArielA;Grover,Aarushi;Foote,Molly;Ota,Yusuke;Berman,Robert;Hanks,Timothy;Hell,JohannesW
• 通讯作者: Hell,JohannesW

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using Poly(I:C) to Study Susceptibility and Resilience in Offspring.

• DOI: 10.3791/64095
• 发表时间: 2022-08-17
• 期刊: Journal of visualized experiments : JoVE
• 作者: Prendergast K;McAllister AK
• 通讯作者: McAllister AK